单中心卵巢畸胎瘤患者中合并抗N-甲基-D-天冬氨酸受体脑炎的比例调查及临床特征分析

目的探究卵巢畸胎瘤患者中发生抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎的比例,并将合并抗NMDAR脑炎的卵巢畸胎瘤患者与未合并抗NMDAR脑炎的卵巢畸胎瘤患者的临床特征进行总结对比。方法收集卵巢畸胎瘤患者的临床资料,将其分为合并抗NMDAR脑炎组与未合并抗NMDAR脑炎组,对其临床特征进行对比分析。结果共收集到168例卵巢畸胎瘤患者,其中14例(8.3%)合并抗NMDAR脑炎;合并抗NMDAR脑炎的卵巢畸胎瘤患者年龄低于未合并抗NMDAR脑炎的卵巢畸胎瘤患者[(23.8±5.5)岁vs.(29.8±9.1)岁,P=0.016]。合并抗NMDAR脑炎的卵巢畸胎瘤患者肿瘤标志物以癌抗原125及血清铁蛋白升高为主,而未合并抗NMDAR脑炎的卵巢畸胎瘤患者肿瘤标志物以糖类抗原199升高为主。合并抗NMDAR脑炎与未合并抗NMDAR脑炎的卵巢畸胎瘤患者的肿瘤组织均可含有神经组织。结论卵巢畸胎瘤患者中发生抗NDMAR脑炎的比例不低,对于无明显症状的卵巢畸胎瘤患者,可考虑积极行手术治疗,以降低发生抗NMDAR脑炎的风险。     

CT引导下组织间植入125Ⅰ放射粒子结合中药治疗脊柱转移瘤的临床应用体会

目的:介绍CT引导下组织间植入125I放射粒子结合中药治疗脊柱转移瘤的技术方法并评价具体临床价值.方法:12例脊柱转移瘤患者,均在CT引导下进行肿瘤内125I粒子植入术.使用的设备为东软公司生产的双排螺旋CT-Neuviz Dual,采用珠海和佳公司生产的TPS计划系统及穿刺针,中科院生产的125I粒子.首先根据肿瘤的大小,利用放射性粒子治疗计划系统计算出治疗肿瘤所需要125I的最佳数量,然后经CT导向下经皮穿刺将125I粒子均匀植入到肿瘤内进行组织间放疗、并配以中医中药.结果:所有病人术后1个月、2个月、3个月内分别进行CT检查随访.结论:CT引导下组织间植入125I放射粒子结合中药治疗是一种治疗脊柱转移瘤安全可靠、疗效显著的治疗方法.     

慢性心力衰竭患者血清CA125测定及其意义

在慢性充血性心力衰竭（CHF）发病机制的研究中,肿瘤基因的异常表达引起了人们的重视。本研究测定了慢性CHF患者血清卵巢癌相关糖类抗原（CA）125水平,以探讨其与慢陛CHF患者心功能的关系。     

老年肺腺癌脑转移预后预测模型的构建

目的:构建老年肺腺癌脑转移预后的预测模型.方法:选择2013年1月至2016年12月成都市第七人民医院接诊的195例肺癌患者进行研究.模型建立前入组的142例患者为A组,模型建立后入组的53例患者为B组.采用COX风险回归模型、随机生存森林、改良递归分区分析和风险预后评估指数对患者进行预后模型的建立.结果:COX风险回...     

CA199．及CA125在不同程度的肝病患者中的诊断价值

目的探讨血清胰腺、肠癌相关抗原（CA199）、卵巢癌相关抗原（CA125）水平在不同程度的肝病中的诊断价值。方法应用化学发光免疫分析各阶段患者进行了血清CA199、CA125水平检测。结果肝癌组患者CA199明显高于其余3组,肝癌组以及肝硬化失代偿期组患者的CA125显著高于其余2组,且CA199水平随着黄疸水平的增高明显增高,腹水性状为渗出液的患者血清中CA125的水平明显高于其余2组。结论CA199、CA125水平可作为肝硬化与肝癌的辅助诊断指标,CA199的高低与黄疸的水平一致,CA125对于肝硬化腹水性状有辅助诊断价值。     

超声介导125I放射性粒子植入治疗晚期恶性肿瘤

目的探讨超声引导^125I放射性粒子植入治疗晚期恶性肿瘤的可行性和效果。 方法在超声引导下，经皮或经阴道穿刺晚期恶性肿瘤，并依据放射治疗计划植入适当数量的^125I放射性粒子。 结果28例患者均获成功。超声能清晰显示肿块，准确引导植入针的插入，成功监视粒子的植入。 结论超声引导^125I放射粒子植入治疗晚期恶性肿瘤安全、微创、并发症少，疗效肯定。     

NHL患者血清CA125、LDH检测的临床意义

测定82例初治非霍奇金淋巴瘤(NHL)患者治疗前后血清CA125、乳酸脱氢酶(LDH)含量。结果血清CA125升高35例,LDH升高35例;正常血清CA125和LDH者、其中一个指标增高者、两个指标均增高者放化疗的完全缓解率分别为85.7%、62.2%、29.4%,两两比较均有显著统计学差异(P均<0.05)。表明血清LDH和CA125是NHL有价值的预后判定指标。     

甘氨双唑钠(CMNa)联合紫杉醇加卡铂化疗对中晚期卵巢癌术后CA125升高的影响

目的 观察甘氨双唑钠（cMNa）联合紫杉醇加卡铂化疗对卵巢癌术后CA125升高的影响。方法 回顾性分析25例中晚期卵巢癌术后患者应用（CMNa）联合紫杉醇加卡铂对CA125升高的影响,并与20例未用CMNa的对照组比较。结果 CMNa联合紫杉醇加卡铂组在化疗1周期后血浆CA125水平与对照组比较有下降趋势,但差异无统计学意义,化疗2周期后血浆CA125水平与对照组比较明显下降,不良反应两组相似。结论 对于晚期卵巢癌术后CA125升高,CMNa联合紫杉醇加卡铂化疗能加快CA125的降低,提示CMNa联合紫杉醇加卡铂化疗晚期卵巢癌有化疗增敏作用。     

Extremely high serum CA19-9 level along with elevated D-dimer in assisting detection of ruptured ovarian endometriosis

BackgroundTo clarify clinical importance of serum CA19-9, CA-125, and plasma D-dimer (D-D) levels in detecting spontaneously ruptured ovarian endometriosis (OE).Materials and MethodsWe retrospectively examined 173 patients with endometriosis out of 735 cases of OE between 2013 and 2019. Among these, 21 cases were diagnosed as “spontaneously ruptured” after surgery, while the remaining cases were unruptured. Venous blood was collected pre-operatively to detect CA19-9, CA-125, and D-D levels. A receiver operating characteristic curve analysis was applied to test clinical value of each marker.ResultsAmong the 21 patients with ruptured OE, 16 had a history of pelvic cysts, 19 claimed sudden onsets of lower abdominal pain, and fluid accumulation were detected in cul-de-sac in only six participants by ultrasound. For serological investigation, both CA19-9 and D-D were significantly elevated in the ruptured OE group (343.09 ± 367.67 U/ml vs. 36.84 ± 40.01 U/ml, 3.39 ± 4.90 mg/L vs. 0.43 ± 0.29 mg/L, both p < .0001). The area under curve (AUC) value for the combination of CA19-9 and D-D was 0.975 (95% CI, 0.939 − 0.993), with specificity of 96.69%, and sensitivity of 85.71%. The combination of CA-125, CA19-9 and D-D showed the highest AUC value that up to 0.976 (95% CI, 0.940–0.993), with sensitivity of 95.24%, and specificity of 87.50%.ConclusionThe combination of CA19-9 and D-D can be chosen as an effective and economical indicators to identify patients with spontaneously ruptured OE in pre-operation assessment. However, from the perspective of differential diagnosis, the combination of CA-125, CA19-9 and D-D is the best choice.

Key messages

• Taking into account the economic effect, the combination of CA19-9 and D-D can be chosen as an effective indicators to identify patients with spontaneously ruptured OE in pre-operation assessment.
• From the perspective of differential diagnosis, the combination of CA-125, CA19-9 and D-D is the best choice to identify patients with spontaneously ruptured OE.

     

CA125、CA199与CEA联合检测对卵巢癌的诊断价值分析

目的 分析糖类抗原125(CA125)、糖类抗原199(CA199)与癌胚抗原(CEA)联合检测对卵巢癌的诊断价值.方法 选取100例卵巢癌患者作为研究组,同时期100例行常规体检健康者作为对照组,两组均行CA125、CA199与CEA检测.对比两组的CA125、CA199与CEA水平、单项检测及联合检测阳性率;对比C...