全文获取类型
收费全文 | 17813篇 |
免费 | 1272篇 |
国内免费 | 417篇 |
专业分类
耳鼻咽喉 | 458篇 |
儿科学 | 71篇 |
妇产科学 | 185篇 |
基础医学 | 932篇 |
口腔科学 | 1311篇 |
临床医学 | 1184篇 |
内科学 | 1605篇 |
皮肤病学 | 1423篇 |
神经病学 | 378篇 |
特种医学 | 558篇 |
外国民族医学 | 1篇 |
外科学 | 4014篇 |
综合类 | 2087篇 |
现状与发展 | 1篇 |
预防医学 | 373篇 |
眼科学 | 3513篇 |
药学 | 786篇 |
8篇 | |
中国医学 | 279篇 |
肿瘤学 | 335篇 |
出版年
2024年 | 70篇 |
2023年 | 317篇 |
2022年 | 660篇 |
2021年 | 784篇 |
2020年 | 622篇 |
2019年 | 509篇 |
2018年 | 506篇 |
2017年 | 579篇 |
2016年 | 665篇 |
2015年 | 562篇 |
2014年 | 1030篇 |
2013年 | 1136篇 |
2012年 | 870篇 |
2011年 | 997篇 |
2010年 | 856篇 |
2009年 | 868篇 |
2008年 | 837篇 |
2007年 | 818篇 |
2006年 | 756篇 |
2005年 | 671篇 |
2004年 | 619篇 |
2003年 | 525篇 |
2002年 | 437篇 |
2001年 | 453篇 |
2000年 | 367篇 |
1999年 | 281篇 |
1998年 | 304篇 |
1997年 | 293篇 |
1996年 | 254篇 |
1995年 | 206篇 |
1994年 | 214篇 |
1993年 | 191篇 |
1992年 | 165篇 |
1991年 | 155篇 |
1990年 | 127篇 |
1989年 | 113篇 |
1988年 | 103篇 |
1987年 | 107篇 |
1986年 | 87篇 |
1985年 | 106篇 |
1984年 | 92篇 |
1983年 | 60篇 |
1982年 | 47篇 |
1981年 | 38篇 |
1980年 | 26篇 |
1979年 | 7篇 |
1978年 | 9篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
41.
1993年11月至1996年5月应用改进的经尿道非接触式激光治疗前列腺增生120例,并对病人进行术前术后的症状评分,尿动力学,残余尿检查,随访病人1-24个月,结果显示病人无论是症状评分,还是尿流率,残余尿等各项指标均有明显的改善,此种手术具有简单,安全,副作用小,术后恢复快,治疗效果好等优点。 相似文献
42.
43.
44.
Monitoring of skin response to sodium lauryl sulphate: clinical scores versus bioengineering methods
The present trial was designed to evaluate clinical scores (single observer) of sodium lauryl sulphate (SLS)-induced skin irritation in a group of subjects (n = 10) over a 10-day period along with various skin function parameters. In order to avoid significant variations due to secondary phenomena, the following parameters were recorded with non-invasive instruments in this order: skin capacitance (C1; arbitrary units; CM420 Corneometer), transepidermal water loss (TEWL; g/m2.h; Evaporimeter) and laser Doppler flowmetry (CBFV: cutaneous blood flow values; Periflux). All examinations were performed during winter on reclined relaxed subjects present for at least 10 min in a test room with controlled temperature and relative humidity (t degrees: 19.5-20.7 degrees C and RH: 47.3-60.3%). The analysis of differential data (delta = value at tx-value before test; 2-way ANOVA) was made on single parameters as a function of site (volar forearm versus neck) and time (from 24 h after 48-h occlusion with 5% SLS up to 10 days later). The profile of erythema scores over time differed between neck and forearm, but the delta CBFV readings with the laser Doppler instrument did not detect significant site-time interactions. Roughness (blind evaluation with palpating finger) and capacitance readings (delta C1) showed significant differences between sites, but the profile over time was similar in both locations. delta TEWL did not differ according to anatomical location. The reason for different erythema scores on neck and forearm might be related to inherent regional variation of optical properties of the skin or to a substantial contribution of SLS-induced roughness to the readings of erythema.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
45.
Takanori Suzuki Kohei Kurokama Hidetoshi Yamanaka Liong Men Long Norio Daikuzono 《Lasers in surgery and medicine》1994,14(1):71-82
Prostatectomy by transurethral balloon Laserthermia (PROSTA-LASE?) was performed in a canine model. This balloon device monitored by transrectal ultrasound can cylindrically irradiate with a laser beam. The treatment was performed in 8 canines using 15 watts for 20 minutes at 60°C at a 5 mm depth of the prostate from the urethral surface. Immediately following the laser therapy, an area of coagulation necrosis was observed around the urethra to a depth of 4–5 mm from the surface. After 1 week, cavitation formation was seen in 3 or 4 canines by ultrasound, and the urethral reepithelialization was shown in 1 of 2 canines. After 2 weeks, cavitation formation was observed in both canines, and the urethra was completely reepithelialized in one canine. There was no tissue damage in the bladder neck of urethral sphincter and no urinary incontinence in any animal. This system is thought to be simple and, satisfactorily performed, is an effective transurethral prostatectomy. © 1994 Wiley-Liss, Inc. 相似文献
46.
The effects of combined use of earthworm extract(912)and HpD-laser on the produc-tion of reactive oxygen and the biosynthesis of DNA in S_(180) tumor cells were studied throughchemiluminescence measurement and[~3H]-TdR incorporation assay.The results showed that as com-pared with the control,the intensity of chemiluminescence emitted by tumor cells treatedsimultaneously with 912 and HpD-laser was enhanced more than ten-folds,while that treated with912 or HpD-laser alone was increased only 2~4 folds.The[~3H]-TdR incorporation into tumorcells of the former group was inhibited upto 74.1%,and that of the latter groups decreased onlyby 42.2% and 40.0%,respectively.In accordance with these biochemical changes,the ultrastructuraldamage of tumor cells of the former,combinedly treated group appeared to be the most serious.This suggests an additive effect of 912 with HpD-laser on tumor cells.In addition,if free radicalscavengers,such as catalase and superoxide dismutase,were added to the reaction systembefore chemiluminescence assay,the luminescent enhancement effect mentioned above was dramaticallyalleviated,implying the presence of O_2~ and H_2O_2 in the system.Therefore,as to the toxic effecton tumor cells,912 and HpD-laser are not only additive in efficiency,but also similar in theunderlying mechanism of action. 相似文献
47.
Dr C. J. Whitters T. W. Macfarlane D. Mackenzie H. Moseley R. Strang 《Lasers in medical science》1994,9(4):297-303
Pulsed Nd-YAG laser irradiation of bacteria has been suggested as a possible means of treating contaminated intra-oral sites
although relatively few studies have been conducted. In this investigation, the antimicrobial activity of a pulsed Nd-YAG
laser was assessed in vitro for a range of oral bacteria using several pulse energies and exposure durations. Pure cultures
of each organism were lased in saline suspensions followed by standard colony counting techniques for test and control samples.
Microbial inhibition was found to be organism-dependent and varied with energy dose and pulse energy. For all nine test species
120-mJ laser pulses proved more efficient than 80-mJ pulses, with 99.9% kills compared with around 90% kills after exposure
to 1800 pulses. These killing activity levels compare favourably with those achieved with other lasers in vitro. 相似文献
48.
M Buchelt H P Kutschera T Katterschafka H Kiss B Schneider R Ullrich 《Lasers in surgery and medicine》1992,12(4):375-381
Erb:YAG and Hol:YAG laser ablation rates of fibrocartilage and nucleus pulposus were measured in vitro simulating clinical conditions. After ablation macroscopic and microscopic appearance of the ablation site was investigated. Hol:YAG and Erb:YAG laser mean ablation rates increased almost linearly with rising energies, showing higher total ablation rates for the Hol:YAG laser due to its higher achievable energy density. At comparable energy densities the Erb:YAG laser appears to be more effective with respect to the corresponding ablation rates. Consequently, the ablational threshold proved to be lower for the Erb:YAG laser. Whereas during Hol:YAG laser ablation, some smoke formation and considerable tissue shrinking occurred, these effects could not be observed during Erb:YAG laser ablation. Consequently macroscopic and microscopic inspection showed some thermal damage after Hol:YAG and only minimal alterations after Erb:YAG laser ablation. Adjacent thermal damage was determined and proved to be lower for the Erb:YAG laser. In our opinion the characteristics of each laser system provide certain advantages for special clinical indications. 相似文献
49.
Summary To characterize and compare the pathologic, hemodynamic and electrocardiographic changes of both transeatheter laser and electrical
energy on ventricle, 33 subendocardial myocardium lesions were induced at energy 60, 120 and 240 Joules by either transcatheter
laser irradiation or electrical shock in 7 anesthetized dogs. The following results were observed: 1) Both laser and electrical
ablation on myocardium created nonhomogeneous myocardium injury, but laser ablation caused mainly focal tissue vaporization
and necrosis, while electrical shock induced widespread tissue degenerations; 2) Both laser and electrical induced-lesion
dimensions increased parallel to the total dosage of energy; 3) Laser ablation caused mainly (90%) single ventricular premature
beats and 86 % of them occurred within the first minute after energy discharged, while ventricular tachycardias were found
in any electrical energy groups; ventricular fibrillations occurring during laser and electrical ablation were 5 % and 13
% respectively (P< 0.01): 4) A decrease in aortic blood pressure and an increase in central verous pressure induced by laser ablation were
significantly less than that produced by the same amount of electrical energy (P<0.0l). Our preliminary results have shown that transeatheter laser ablation has great potential for becoming a practical
method in the management of refractory tachycardias. 相似文献
50.
弱激光血疗法的发展及展望 总被引:3,自引:1,他引:2
本文主要介绍了弱激光血疗的机制及其在我国的发展过程.弱激光血疗法起源于前苏联的紫外光量子疗法,传入我国后经历了静脉内照射疗法,离体血液激光照射回输疗法,口咽部照射伴吸氧疗法,鼻腔内照射疗法等.本文对各种疗法的特点及临床应用进行了详细叙述.有些学者认为,中医的观点也能揭示激光血疗的机制.从中医辨证的角度,人的体质分为虚证和实证.结合中医针灸的虚则补之,实则泻之的原理,根据患者的虚实状况,采用含有中医补泻信息的调制激光照射血液,同时加照相关敏感穴位,促进疗效,以体现中医的辨证施治的原则可取得更好的疗效. 相似文献