针灸综合治疗面瘫

面瘫多由脉络空虚、风寒侵袭、瘀滞经脉所致,毫针刺法、梅花针、隔姜灸并用能疏通经络,祛风散寒,调和气血,疗效显著,值得推广。     

针灸调理阳虚体质治疗上热下寒型痤疮疗效观察

目的观察针灸调理阳虚体质治疗上热下寒型痤疮的临床疗效。方法 96例诊断为上热下寒型痤疮患者采用针灸配合局部痤疮处理治疗。治疗3个疗程后对患者治疗前后痤疮皮损、阳虚体质积分和病情分级改善情况进行评价。结果患者经治疗后,治愈24例,显效42例,有效21例,无效9例,总有效率为90.6%。患者治疗后皮损积分、体质积分及病情分级与治疗前比较,差异均具有统计学意义(P0.05)。结论针灸调理阳虚体质治疗上热下寒型痤疮疗效客观,能改善阳虚体质状态并干预疾病病情。     

Therapeutic potential of ginger against COVID-19: Is there enough evidence?

In addition to the respiratory system, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strikes other systems, including the digestive, circulatory, urogenital, and even the central nervous system, as its receptor angiotensin-converting enzyme 2 (ACE2) is expressed in various organs, such as lungs, intestine, heart, esophagus, kidneys, bladder, testis, liver, and brain. Different mechanisms, in particular, massive virus replication, extensive apoptosis and necrosis of the lung-related epithelial and endothelial cells, vascular leakage, hyper-inflammatory responses, overproduction of pro-inflammatory mediators, cytokine storm, oxidative stress, downregulation of ACE2, and impairment of the renin-angiotensin system contribute to the COVID-19 pathogenesis. Currently, COVID-19 is a global pandemic with no specific anti-viral treatment. The favorable capabilities of the ginger were indicated in patients suffering from osteoarthritis, neurodegenerative disorders, rheumatoid arthritis, type 2 diabetes, respiratory distress, liver diseases and primary dysmenorrheal. Ginger or its compounds exhibited strong anti-inflammatory and anti-oxidative influences in numerous animal models. This review provides evidence regarding the potential effects of ginger against SARS-CoV-2 infection and highlights its antiviral, anti-inflammatory, antioxidative, and immunomodulatory impacts in an attempt to consider this plant as an alternative therapeutic agent for COVID-19 treatment.     

基于UHPLC-UV-Q-TOF-MS/MS的厚朴不同方法姜制前后化学成分定性研究

采用UHPLC-Q-TOF-MS/MS技术定性分析方法,探讨厚朴姜制前后以及不同姜制方法化学成分变化。定性采用正负离子扫描模式,利用Peakview1. 2软件分析鉴定出35种成分,发现厚朴姜制前后质变成分较少,并结合Marker-View1. 2. 1软件进行主成分分析和t检验,得出6种主要差异性成分发现厚朴经过姜炙之后厚朴酚、厚朴三酚、十四烷酸、十六烷酸含量增加,蓝桉醇含量减少,上述化学成分的差异可能是厚朴生品和制品临床功效不同的主要原因。     

电针配合神阙穴隔盐隔姜灸治疗产后尿潴留48例

目的观察电针配合神阙穴隔盐隔姜灸治疗产后尿潴留的临床疗效。方法93例患者随机分为治疗组和对照组。治疗组采用电针三阴交、阴陵泉、关元、中极穴配合神阙穴隔盐隔姜灸治疗,对照组采用单纯电针治疗,治疗后观察疗效。结果治疗组有效率为97.9%,对照组有效率为80.0%,两组比较有显著性差异（P〈0.05）。结论电针三阴交、阴陵泉、关元、中极穴配合神阙穴隔盐隔姜灸对产后尿潴留有较好的疗效。     

正交试验法优选姜半夏炮制工艺

目的筛选确定姜半夏最佳炮制工艺。方法采用L9（3）4正交试验法,以姜半夏中有机酸、生物碱和白矾残留量为考察指标,用综合加权评分法优选姜半夏炮制工艺。结果白矾用量为主要影响因素,生姜用量影响不显著,优选的炮制工艺为：每100 g半夏用生姜25 g,白矾12.5 g,煮制5 h。结论优选得到的炮制工艺简便易行,有良好的重复性和可操作性,有助于姜半夏质量控制。     

Effect of Ginger and Novafen on menstrual pain: A cross-over trial

Objective

Menstrual pain is a periodic pain which happens during the days of menses. The menstrual disturbances as a health problem among young girls affect not only reproductive, but also psychical health and quality of life. This study was done with the goal of comparing the effect of Ginger and Novafen on the menstrual pain.

A comparison between the effects of ginger,pyridoxine (vitamin B6) and placebo for the treatment of the first trimester nausea and vomiting of pregnancy (NVP)

Introduction: Nausea and vomiting of pregnancy (NVP) are one of the most common complains of the early pregnancy period and are bothersome for pregnant women. Some prefer to use herbal medicine instead of chemical agents.

Objective: The purpose of the present study was to compare the effects of ginger, pyridoxine (vitamin B6), and placebo for the treatment of NVP.

Method: The study was performed as a triple blind clinical trial on pregnant women suffering mild to moderate NVP between 6 and 16 weeks of pregnancy. In these women ginger, 500?mg twice daily, vitamin B6 40?mg twice daily and placebo twice daily were administered for 4?d. Rhodes questionnaire was used for evaluation of the severity of symptoms. The severity of NVP was evaluated 24?h before entering the study and up to 4 d after using medications and results were compared among the three groups.

Results: Seventy-seven women finished the study (28 in the Ginger group, 26 in the B6 group, and 23 in the placebo group). The women of the three groups did not have significant differences according to age, gestational age, parity, and severity of each symptom before treatment and educational status. Total score of Rhodes questionnaire for nausea was decreased significantly in three groups after treatment. (p?p?=?.012, and p?=?.03 for ginger, vitamin B6, and placebo, respectively.) Also total score of Rhodes questionnaire for vomiting was decreased in three groups (p?=?.03 for ginger, p?=?.02 for B6, and p?=?.04 for placebo). Ginger and vitamin B6 could reduce the severity of all items of Rhodes questionnaire significantly; however, placebo was significantly effective only on the frequency of nausea, intensity of vomiting and frequency of retching. Ginger and vitamin B6 were more effective than placebo (p?=?.039 and p?=?.007, respectively); however, total score of Rhodes did not show significant difference between ginger and vitamin B6 (p?=?.128). Ginger was more effective for nausea (intensity and distress) and distress of vomit.

Conclusion: Ginger is more effective than placebo for the treatment of mild to moderate NVP and is comparable with vitamin B6.

Trial registration number and registry website: IRCT2015020320923N1     

Species differences in the prokinetic effects of ginger

This study describes the prokinetic actions of the aqueous extract of ginger (Zingiber officinale). Ginger extract (Zo.Cr), which tested positive for saponins, terpenes, phenols, flavonoids and alkaloids, showed a spasmogenic effect in isolated guinea-pig ileum with 8–50 times more potency than in rabbit jejunum and ileum and rat stomach fundus and ileum. Spasmogenicity in all the gut preparations except in guinea-pig ileum was atropine-sensitive. Zo.Cr exhibited a stimulant effect in vivo in mice and enhanced the intestinal transit of charcoal meal. A spasmolytic effect, mediated via Ca^2?+? antagonist activity, was also exhibited by Zo.Cr, reflected in terms of inhibition of spontaneous contractions, K⁺ (80 mM)-induced contractions and displacement of Ca^2?+? dose–response curves. The ginger pure compounds (6-shogaol, 6-gingerol, 8-gingerol and 10-gingerol) also exhibited a spasmolytic activity, which reduced with the increasing size of the side chain in their chemical structures. The study showed that the aqueous extract of ginger exhibits species-specific spasmogenicity in gut tissues of rabbit and rat (muscarinic-type) while through an uncharacterized pathway in guinea-pig ileum, along with a dormant relaxant effect, mediated via the blockade of voltage-dependent Ca^2?+? channels.