全文获取类型
收费全文 | 1920篇 |
免费 | 92篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 36篇 |
妇产科学 | 10篇 |
基础医学 | 190篇 |
口腔科学 | 20篇 |
临床医学 | 269篇 |
内科学 | 267篇 |
皮肤病学 | 19篇 |
神经病学 | 224篇 |
特种医学 | 185篇 |
外科学 | 171篇 |
综合类 | 208篇 |
预防医学 | 37篇 |
眼科学 | 23篇 |
药学 | 87篇 |
中国医学 | 24篇 |
肿瘤学 | 265篇 |
出版年
2023年 | 27篇 |
2022年 | 88篇 |
2021年 | 88篇 |
2020年 | 73篇 |
2019年 | 75篇 |
2018年 | 60篇 |
2017年 | 65篇 |
2016年 | 61篇 |
2015年 | 71篇 |
2014年 | 160篇 |
2013年 | 113篇 |
2012年 | 116篇 |
2011年 | 107篇 |
2010年 | 105篇 |
2009年 | 96篇 |
2008年 | 96篇 |
2007年 | 107篇 |
2006年 | 60篇 |
2005年 | 77篇 |
2004年 | 51篇 |
2003年 | 45篇 |
2002年 | 34篇 |
2001年 | 26篇 |
2000年 | 24篇 |
1999年 | 15篇 |
1998年 | 19篇 |
1997年 | 19篇 |
1996年 | 18篇 |
1995年 | 12篇 |
1994年 | 20篇 |
1993年 | 18篇 |
1992年 | 11篇 |
1991年 | 8篇 |
1990年 | 10篇 |
1989年 | 9篇 |
1988年 | 7篇 |
1987年 | 11篇 |
1986年 | 4篇 |
1985年 | 9篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 3篇 |
1978年 | 2篇 |
1976年 | 2篇 |
1973年 | 2篇 |
1972年 | 1篇 |
1971年 | 2篇 |
1969年 | 1篇 |
排序方式: 共有2047条查询结果,搜索用时 15 毫秒
101.
Sakai F Noma S Kurihara Y Yamada H Azuma A Kudoh S Ichikawa Y 《Modern rheumatology / the Japan Rheumatism Association》2005,15(3):173-179
Imaging findings of 26 cases of leflunomide (Arava)-related acute lung injury were analyzed. Thirteen cases had pre-existing interstitial pulmonary disease on chest X-ray or computed tomography. The main features of clinically determined leflunomide-induced acute lung injury were similar to those caused by other drugs: diffuse or widespread patchy ground-glass opacities and/or consolidation, frequently accompanied by septal thickening and intralobular reticular opacities. We categorized these findings into four patterns: diffuse alveolar damage (DAD), acute eosinophilic pneumonia, hyperreaction, and cryptogenic organizing pneumonia. The DAD group had a higher mortality rate, but statistically not a significant one. It is impossible to exclude infectious disease such as pneumocystis carinii pneumonia based on imaging findings, and detailed correlation of imaging findings with clinical and laboratory findings is essential in order to make a correct diagnosis. 相似文献
102.
Christopher D. King Fong Wong Tom Currie Andre P. Mauderli Roger B. Fillingim Joseph L. Riley rd 《Pain》2009
Females with Irritable Bowel Syndrome (IBS) and Temporomandibular Disorder (TMD) are characterized by enhanced sensitivity to experimental pain. One possible explanation for this observation is deficiencies in pain modulation systems such as Diffuse Noxious Inhibitory Control (DNIC). In a few studies that used brief stimuli, chronic pain patients demonstrate reduced DNIC. The purpose of this study was to compare sensitivity to prolonged heat pain and the efficacy of DNIC in controls to IBS and TMD patients. Heat pain (experimental stimulus; 44.0–49.0 °C), which was applied to left palm, was continuously rated during three 30-s trials across three separate testing sessions under the following conditions: without a conditioning stimulus; during concurrent immersion of the right foot in a 23.0 °C (control); and during noxious cold immersion in a (DNIC; 8.0–16.0 °C) water bath. Compared to controls, IBS and TMD patients reported an increased sensitivity to heat pain and failed to demonstrate pain inhibition due to DNIC. Controls showed a significant reduction in pain during the DNIC session. These findings support the idea that chronic pain patients are not only more pain sensitive but also demonstrate reduced pain inhibition by pain, possibly because of dysfunction of endogenous pain inhibition systems. 相似文献
103.
《Surgical pathology clinics》2017,10(2):429-453
Epstein-Barr virus (EBV)–associated lymphoproliferations involving the skin are a rare but important group of diseases with a broad spectrum of behavior, ranging from self-limiting spontaneously resolving disorders to highly aggressive malignancies. They may be of B, T, or natural killer (NK) cell type and include EBV-positive mucocutaneous ulcer, lymphomatoid granulomatosis, EBV-positive diffuse large B-cell lymphoma, hydroa vacciniforme–like lymphoproliferative disorder, and extranodal NK/T-cell lymphoma of nasal type. Recognition and distinction of these entities is important in view of their differing prognoses and treatments. An association with EBV may be the first indication that a patient is immunosuppressed. 相似文献
104.
F Roviello G Corso C Pedrazzani D Marrelli G De Falco A Berardi L Garosi G Suriano C Vindigni A De Stefano L Leoncini R Seruca E Pinto 《European journal of surgical oncology》2007,33(4):448-451
AIMS: Germline mutation of the E-cadherin gene (CDH1) accounts for the Hereditary Diffuse Gastric Cancer (HDGC) syndrome. Fourteen pedigrees with Diffuse Gastric Cancer that fulfilled the International Gastric Cancer Linkage Consortium (IGCLC) criteria were selected and screened for CDH1 germline mutations. METHODS: The entire coding region of the CDH1 gene and all intron-exon boundaries were analyzed by direct sequencing in the 14 families fulfilling the IGCLC criteria. E-cadherin immunohistochemical expression was evaluated on tumour as well as normal formalin-fixed paraffin embedded tissues. RESULTS: A novel germline missense mutation was found. It was a single C-->T substitution in exon 8, resulting in a transition of CCG-->CTG (C1118T; Pro373Leu) demonstrated in the proband and her brother. At immunohistochemical analysis, the staining intensity was reduced and considered weakly positive (15%). CONCLUSIONS: The first CDH1 germline mutation of an Italian family is herein reported. The present missense mutation has never been described so far. 相似文献
105.
弥漫性轴索损伤研究进展 总被引:3,自引:0,他引:3
弥漫性轴索损伤(DAI)是用于描述头部伤后以脑深部神经轴索肿胀、断裂为特征的脑损伤类型。本文就近年来对DAI研究进展包括发生机制、病理特征、临床表现、诊断及其治疗综述如下。 相似文献
106.
107.
磁共振弥散成像是通过水分子弥散差异成像,反映水分子弥散运动状态。由于成像原理不同于传统磁共振,故弥散成像对中枢神经纤维束的解剖结构改变较为敏感,从而成为弥漫性轴突损伤诊断的重要技术。弥散加权成像能通过突出弥散效应显示损伤灶;弥散张量成像能反映各向异性矢量,更加敏感地显示损伤灶,并可通过神经纤维束成像显示轴突损伤。弥散成像不仅提高了弥漫性轴突损伤的诊断,还有利于判断伤情及预后。该作者对以上问题作一综述。 相似文献
108.
B. Roth A. Younossi-Hartenstein R. Schröder H. Hörnchen L. Heymans 《European journal of pediatrics》1987,146(1):83-85
We present the case of a 4.5-week-old boy with acute encephalopathy, shock, intestinal bleeding and disseminated intravascular coagulation. The clinical course and typical laboratory parameters were compatible with a diagnosis of haemorrhagic shock-encephalopathy syndrome (HSE). Immediate shock treatment, repeated haemodialysis and plasmapheresis did not prevent a fatal outcome 4 days after the onset of clinical symptoms.Abbreviations HSE
haemorrhagic shock-encephalopathy syndrome
- HUS
haemolytic uraemic syndrome 相似文献
109.
弥漫性脑损伤大鼠脑组织细胞间粘附分子-1的表达与神经元损伤 总被引:2,自引:1,他引:2
目的观察细胞间黏附分子-1(ICAM-1)在大鼠弥漫性脑损伤不同时程的表达与脑组织神经元损伤。方法荧光实时定量RT-PCR和免疫组化分别测定ICAM-1mRNA和蛋白在大鼠弥漫性脑损伤不同时程的表达,光镜和电镜观察神经元的变化。结果外伤后6h脑组织中ICAM-1蛋白的表达开始升高(阳性微血管数4.8±0.8),72h达高峰(17.2±2.4),高于假手术对照组(0.4±0.5)(P<0.05)。ICAM-1mRNA表达3h即明显升高(△Ct:13.48±3.93),72h达最高(20.59±0.97),7d(15.60±0.01)仍高于假手术对照组(4.66±1.11)(P<0.01)。光镜及电镜下可见弥漫性神经元变性水肿和坏死,72h损伤最重。结论大鼠脑外伤后ICAM-1表达升高,介导了粒细胞与脑血管内皮黏附增强,ICAM-1可能参与了外伤后炎症反应和神经元损伤的病理过程。 相似文献
110.