流程重组在CT检查预约登记中的实践应用

在分析CT检查登记预约服务流程现状的基础上,从缩短预约时间、减少检查用时和合理安排病人扫描顺序等方面介绍了如何在现有条件下改善登记预约流程,使CT检查最大限度地服务于临床诊治的一些做法.     

对建立我国仿制药注册审批管理配套制度的探讨

为配合新版《药品注册管理办法》的有效实施，有效借鉴国际上仿制药的审批管理经验，提出了我国仿制药注册审批管理亟需建立的配套制度，并对建立的方式进行了讨论。     

新《药品注册管理办法》出台后的药品注册申报工作

新《药品注册管理办法》及其配套的《药品注册现场核查管理规定》的出台,对于药品注册申报提出了更高的要求。本文主要说明修订后的《药品注册管理办法》主要变化的内容和要求,并就今后药品研发和注册申报中需要注意的几个问题进行探讨。     

浅谈《药品注册管理办法》变化后的新药研发

本文针对新颁布的《药品注册管理办法》关于新药注册申请的一些变化,分析了对我国新药研发行业的影响,并提出新形势下新药研发的新对策。     

基于Talairach坐标的SPECT脑99mTc-ECD显像分区灰度分析

本文设计了一种基于Talairach坐标的SPECT脑99mTc-ECD显像分区灰度分析方法。选择一个标准化的人群标本,采用图像配准和图像形变方法,将SPECT脑99mTc-ECD显像映射到标准的Talairach坐标空间,按各脑部功能区对全脑中坐标点分类,计算每个脑区摄取信息即平均灰度,并计算其与全脑平均灰度比值,比较左右半球及不同脑区间摄取比值差异。     

An evaluation of process and outcomes from learning through reflective practice groups on a post-registration nursing course

An evaluation of process and outcomes from learning through reflective practice groups on a post-registration nursing course Small groups were set up purposefully on a part-time post-registration Diploma in Professional Studies in Nursing programme to enable students to reflect on and learn from experience. The use of these groups was qualitatively evaluated by the use of in-depth interviews. Although there were many barriers to such learning, some students made significant developments in their critical thinking ability and underwent perspective transformations that led to changes in attitudes and behaviour. These are identified as an increased professionalism, greater autonomy in decision making, more self-confidence to challenge the status quo and make their own judgements, and a less rule-bound approach to their practice. The processes by which these changes occurred are identified as support and challenge within the groups offered by both the facilitators and other group members.     

Effects of repetitive deformation on intestinal epithelial cells

The intestinal mucosa is subject to a variety of physical forces in a complex manner during normal gut function and in disease. Intestinal mucosal atrophy during some disease states is a troubling phenomenon that is only partially explained by nutritional parameters. Increasing evidence suggests the possibility that repetitive deformation engendered by peristalsis, villous motility, and interaction with luminal chyme may be trophic for the gut mucosa in normal function, but that the intestinal epithelial response to repetitive deformation may be altered by inflammatory or other states in which plasma or tissue fibronectin levels are increased. Supported by a Merit Research Award from the United States Department of Veterans’ Affairs, and by NIH RO1 DK067257 and DK060771. Received 12 July 2006; accepted 22 August 2006     

The sex ratio of Igbo births

The study determined that the sex ratio of live-born infants in the Igbo-occupied area of Nigeria is about 1.04. This figure, although similar to the 1.03 reported for Zaire and for the black populations of the US and the Caribbean, is lower than the 1.05 to 1.07 accepted for most European populations, the 1.06 recorded for the Yorubas of western Nigeria, and the 1.07 reported for the Hausa people of one northern Nigerian province. Values ranging from 1.12 to 1.14 have been reported for Africans of Uganda and Cameroun. All these figures are lower than the 1.15 recorded for the Far Eastern peoples and support the widely held impression that the sex ratio at birth is influenced by, among other factors, geographical and genetic distribution. Results of the study of Igbo births also showed that the sex ratio within a homogeneous population varies with place of confinement, from a high in hospitals to a low in community health centers.     

Subvoxel image registration of multislice (2D) magnetic resonance images in patients with high-grade gliomas of the brain

AIMS: To implement a multislice two-dimensional (2D) T2-weighted sequence suitable for subvoxel image registration and to assess its usefulness in detecting change in high-grade intracranial gliomas. MATERIALS AND METHODS: Twenty patients with high-grade gliomas were studied on two or more occasions. T2-weighted multislice pulse sequences with a Gaussian slice profile, 50% overlapping slices and nearly isotropic voxels were acquired. The images were registered and subtraction images were produced. The images were compared with three-dimensional (3D) T1-weighted registered images and conventional unregistered T2-weighted images. All images were scored for changes in the lesions and ventricular system. RESULTS: The 2D and 3D registered subtraction images were the most sensitive for detecting changes in both the lesions and other regions in the brain. The mean rank scores were significantly higher for the lesions (chi2=86.742; df=5, n=38, P<0.0001) and for the ventricles (chi2=63.837; df=5, n=35, P<0.0001) compared with the unregistered and registered anatomical images. The subtraction images were also most sensitive for detecting signal intensity changes irrespective of the direction of change. CONCLUSION: Rigid body subvoxel registration can be successfully performed with both multislice 2D and 3D imaging. In principle, virtually all forms of clinical MR images of the brain can be accurately registered and subtracted.