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141.
M. NISHI H. MIYAKE T. TAKEDA N. TAKASUGI J. HANAI T. KAWAI 《Acta paediatrica (Oslo, Norway : 1992)》1991,80(8-9):812-817
ABSTRACT. On the basis of epidemiological data and medical costs for patients with neuroblastoma, we have calculated the cost of mass screening for neuroblastoma with high performance liquid chromatography (HPLC) compared to the cost when it is not performed. If the sensitivity of the mass screening is 80 % and 22 000 infants are screened annually the cost will be 27809000 yen ($191800). If mass screening is not performed, the cost will be 28 446 000 yen ($196 200). The difference in cost (637 000 yen or $4 400) is fairly small. If the sensitivity is 75 % and 16 500 infants are screened, the difference is also small (174000 yen or $1 200). Therefore, mass screening with the HPLC method will not be an undue financial burden. But re-screening at an older age will be done with less financially favorable results, considering that the sensitivity may not be as high as that of the first screening and that mothers are somewhat reluctant about re-screening. The balance of the cost of mass screening by qualitative methods may also be less favorable, since the detection rate is low. 相似文献
142.
血清MUC1粘蛋白IRMA及其初步临床应用 总被引:13,自引:1,他引:12
建立有效的MUC1粘蛋白免疫放射分析法(IRMA),并初步用于乳腺肿瘤的诊断。利用纯化的MUC1及其多抗,建立MUC1双抗夹心IRMA法,对55例健康女性、11例乳腺良性肿瘤、27例乳腺癌及28例乳腺癌术后患者进行血清MUC1的测定。结果:血清MUC1IRMA的灵敏度为074kU/L;健康女性、乳腺良性肿瘤、乳腺癌及乳腺癌术后患者血清MUC1的平均含量分别为723±367、1780±1056、3004±2384和3184±2479kU/L;正常值上限为1354kU/L,假阳性率为182%;乳腺肿瘤患者血清MUC1水平较健康女性明显提高;乳腺癌患者血清MUC1水平高于乳腺良性肿瘤患者,但两者的阳性率(7787%和7270%)差异无显著性(χ2=0154,P>005);乳腺癌与乳腺癌术后患者血清MUC1水平差异无显著性(t=-022,P>005)。MUC1血清水平与肿瘤恶性程度成正相关,对于乳腺癌的诊断具有重要参考价值。 相似文献
143.
144.
Declan Donovan BSc Dr. Judith H. Harmey PhD Deirdre Toomey BSc D. Henry Osborne MCh H. Paul Redmond MCh David J. Bouchier-Hayes MCh 《Annals of surgical oncology》1997,4(8):621-627
Background: Angiogenesis is essential for tumor growth and metastasis. Vascular endothelial growth factor (VEGF) is the most potent angiogenic
factor identified to date. TGFβ-1 acts as an indirect angiogenic agent.
Methods: VEGF and TGFβ-1 were measured in the serum of breast cancer patients and agematched controls and in tumor tissue of cancer
patients by ELISA. VEGF protein and mRNA expression by breast tumor cell lines were examined, and the effect of TGFβ-1 on
VEGF production in these cells was assessed.
Results: VEGF levels were significantly higher (P=.03) in the serum of patients with breast cancer compared to age-matched controls. A positive correlation was found between
serum (r=0.539) and tumor tissue (r=0.688) levels of VEGF and TGFβ-1. Metastatic MDA-MB-231 breast cancer cells produce more
VEGF than do the primary BT474 cells. TGFβ-1 significantly (P<.05) increased production of VEGF.
Conclusions: Breast cancer cells constitutively produce VEGF protein and mRNA. There is a relationship between VEGF and TGFβ-1 levels
in breast cancer patients, and TGFβ-1 regulates VEGF expression by breast cancer cells.
Presented at the 50th Annual Cancer Symposium of the Society of Surgical Oncology, Chicago, Illinois, March 20–23, 1997. 相似文献
145.
爱婴医院的文化氛围与爱婴医院的建立和发展密切相关。为搞好爱婴医院文化建设与管理,促进母乳喂养,本文对近几年发展起来的爱婴医院文化的构成、功能、特征和今后发展的标准进行了讨论。 相似文献
146.
中期因子和微血管密度在乳腺癌中的表达 总被引:8,自引:0,他引:8
目的 探讨中期因子 (MK)与微血管密度 (MVD)的表达与乳腺癌生物学行为的关系及对预后的意义。方法 采用免疫组织化学方法检测 67例乳腺浸润性导管癌组织MK、MVD表达水平 ,并对其与乳腺癌临床病理特征的关系进行统计学分析。结果 本组 67例中 ,MK阳性表达者 3 7例 ,占 5 5 .2 %。MK表达水平及MVD值均与肿块大小 ,腋淋巴结状态及复发和转移有关。MK表达阳性者的MVD均值 (90 .75± 3 3 .0 5 )明显高于MK表达阴性组 (70 .48± 3 1.3 3 ,P <0 .0 1)。结论 MK在乳腺癌血管生成中发挥重要作用 ,MK的阳性表达与乳腺癌的发生、发展和预后密切相关 ,可作为一种有价值的肿瘤标志和预后指标。 相似文献
147.
KOJI YOSHIMURA NAOKI TERADA YOSHIYUKI MATSUI AKITO TERAI NAOKO KINUKAWA YOICHI ARAI 《International journal of urology》2004,11(5):282-287
BACKGROUND: We examined the prevalence of and risk factors for nocturia in Kurashiki city and the surrounding area, a rural area in Japan. MATERIALS AND METHODS: We collected data on 6517 individuals (4568 men and 1949 women) who participated in a multiphasic health screening. We analyzed the relationships between nocturia assessed by a questionnaire (voiding twice or more during night) and other variables including age, hypertension, cardiovascular disease, cerebrovascular disease, chronic obstructive pulmonary disease, diabetes mellitus (DM), chronic renal failure, benign prostatic hyperplasia (BPH), smoking habit and alcohol intake. RESULTS: Overall, 1856 individuals (28.5%) answered that they arose to urinate at least twice during the night. This rate increased with age from 16.5% in individuals younger than 50 to 60.0% in those older than 69. Logistic regression analysis revealed that cohorts of subjects 50-59, 60-69, and 70 years old or over had, respectively, 1.75, 3.35, and 6.21 times the prevalence of nocturia of the 49 years or younger cohort. Hypertension (odds ratio [OR] 1.64) and DM (OR 1.70) were other independent positive risk factors for nocturia. On the other hand, current smokers who smoked 20 or more cigarettes per day were less likely to have nocturia than non-smokers (OR 0.72). In male individuals, BPH was another independent positive risk factor (OR 1.35). Gender was not associated with nocturia. CONCLUSIONS: Although population bias is an important limitation to this study, nocturia is associated with various factors suggesting that multiple approaches are needed to the treatment of patients with nocturia. 相似文献
148.
老年2型糖尿病患者胰岛素抵抗相关指标的检测和意义 总被引:1,自引:1,他引:0
目的:探讨老年2型糖尿病胰岛素抵抗(IR)及其相关性,为老年2型糖尿病的合理防治提供临床依据。方法:选择120例老年2型糖尿病患者,按胰岛素敏感指数(HOMA)胰岛素抵抗(HOMA-IR)50百分位点将患者分为两组:胰岛素相对敏感组(HOMA-IR<3.56)和胰岛素相对抵抗组(HOMA-IR≥3.56),比较体重指数(BMI)、腰/臀比(WHR)、血压、血生化学检查等指标。用年龄>40岁,<60岁的2型糖尿病患者做对照组。结果:两组老年患者在年龄、性别、舒张压、空腹血糖、胆固醇、高密度脂蛋白、糖化血红蛋白、HOMA胰岛β细胞功能方面无差异;但BMI、WHR、收缩压、甘油三脂、空腹胰岛素、HOMA-IR差异具有显著性。多线性回归分析后,只有腰/臀比、收缩压、甘油三脂、HOMA-IR存在统计学差异。老年患者与对照组相比,IR发生率明显增加,且两者腰/臀比、收缩压、甘油三脂方面也差异显著。结论:IR与老年2型糖尿病密切相关,是临床防治糖尿病的重要靶点。 相似文献
149.
150.
Objective:This sudy was designed to observe somatostatin receptor subtype 2 (SSTR2) Mrna expression, and investigate the correlations between SSTR2 Mrna expression and steroid receptors in benign and malignant lesions of the breast. Methods: A total of 23 breast carcinomas,16 mammary hyperplasia and 9 mammary adenofibroma samples were analysed. The SSTR2 Mrna expression was examined by in situ hybridization using multiphase oligoprobes.The ER and PR were detected by immunohistochemical staining. A computerized image analysis system was utilized to estimate the relative contents of SSTR2 Mrna. Results: The positive rates of expression (87.0%) and relative contents (0.47) of SSTR2 Mrna in breast cancer were higher than those in benign breast lesions(64%,0.26) respectively( P<0.05). SSTR2 Mrna expression was closely correlated with ER and PR in breast cancer( P<0. 05), A positive correlation between SSTR2 Mrna expression and ER was also found in benign breast lesions. Conclusions: SSTR2 Mrna expressed both in benign and in malignant breast lesions, but higher in malignant than in benign ones. There was a significant positive correlation of SSTR2 Mrna expression with ER or PR. The results suggest that conbined treatment with an antiestrogen and a somatostatin analogue for ER-positive breast cancer is feasible. 相似文献