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61.
本文对我院6例原诊断为膀胱葡萄簇状肉瘤的病例进行了临床随访并做了病理组织学研究。全部患者在术后2~12个月内死亡。6例瘤组织的病理学图象基本相同,但有些区域则呈恶性淋巴瘤样或粘液肉瘤样或平滑肌肉瘤样形态。它们虽貌似有多种组织成分,但经特柒证明却只含有胚胎性横纹肌肉瘤成分,而无其它良恶性问叶性瘤组织成分。因此,在病理学命名上,应将它诊断为膀胱横纹肌肉瘤,建议不再使用“葡萄簇状肉瘤”的名称。此外,作者并收集国内文献中报告过的膀胱横纹肌肉瘤(葡萄簇状肉瘤)共69例,结合本文报告6例,详细讨论了它的发病率、命名和组织发生学等临床和病理方面的问题。- 相似文献
62.
表浅性膀胱肿瘤的预后 总被引:6,自引:2,他引:4
从1980年1月至1991年12月,对121例表浅性膀胱肿瘤进行回顾性研究,首次手术采用经尿道肿瘤电灼术,电切术或膀胱部分切除术,术后配合膀胱内灌药辅助治疗。其中60例术后复发(49.6%),术后1、2、3和5年的无瘤率分别为86.8%、76.8%、73.5%和68.6%。资料表明,初诊时呈多发者、直径大于1cm和细胞恶性分级高的肿瘤术后无瘤率分别低于单发者、直径小于1cm和细胞恶性分级低的肿瘤,有显著性差异(P<0.05)。术后6个月内肿瘤复发者经治疗后肿瘤再次复发的机会高。术后膀胱内灌药可以预防肿瘤复发,以灌注丝裂霉素和卡介苗效果好。 相似文献
63.
Lymphoepithelioma-like carcinoma of the bladder: three cases with clinicopathological and p53 protein expression study 总被引:12,自引:0,他引:12
Izquierdo-García FM García-Díez F Fernández I Pérez-Rosado A Sáez A Suárez-Vilela D Guerreiro-González R Benéitez-Alvarez M 《Virchows Archiv : an international journal of pathology》2004,444(5):420-425
Lymphoepithelioma-like carcinoma of the bladder is an uncommon neoplasm, of which 49 cases have been described in the English literature, none of which has been studied for p53 protein expression. We studied three muscle-infiltrating cases of this tumor using immunohistochemical, in situ hybridization and polymerase chain reaction (PCR) methods. The three cases were positive for epithelial markers and negative for lymphoid antigens in the tumoral syncytial areas. The intensive infiltrate of small cells was negative for epithelial and positive for lymphoid markers. This population was mainly made up of cytotoxic T-lymphocytes, positive for TIA-1. p53 protein was intensely positive in more than 90% of the epithelial component nuclei, being negative in the lymphoid cells. PCR study did not show mutations on p53. Both lymphocytes and epithelium were negative for Epstein–Barr virus markers, such as the latent membrane protein and EBER (Epstein–Barr-encoded RNA). The prognosis was very good after radiotherapy and chemotherapy treatment, preserving the bladder despite the muscle infiltration. The presence of an intense cytotoxic T-lymphocyte population may be related to this good prognosis. Both aspects, p53 protein status and T-lymphoid population, had never been studied before in bladder lymphoepithelioma-like carcinoma. 相似文献
64.
目的:探讨单发性和多发性浅表膀胱移行细胞癌组织中血管内皮生长因子(VEGF)的表达及意义。方法:采用免疫组化方法对60例浅表膀胱移行细胞癌组织及10例正常膀胱组织进行血管内皮生长因子(VEGF)的检测,观察单发性和多发性浅表膀胱移行细胞癌组织中VEGF表达的关系。结果:多发性浅表膀胱移行细胞癌VEGF的高表达明显高于单发者的高表达;VEGF高表达的浅表膀胱移行细胞癌的患者的复发率明显高于低表达者的复发率。结论:VEGF表达的高低与浅表膀胱移行细胞癌的生物学行为有关。 相似文献
65.
David W. Ingersoll George Bobotas Ching-Tse Lee Aaron Lukton 《Physiology & behavior》1982,29(5):789-793
The present study was designed to investigate the chemical properties of the aggression-promoting cues present in bladder urine of male mice. The results of the first experiment confirmed earlier work by demonstrating the presence of an aggression-promoting chemosignal in bladder urine. In Experiment 2, behavioral assays were separately performed on the organic and aqueous layers of bladder urine obtained by repeated dichloromethane extractions. Only the combined organic layers of the initial three extractions demonstrated behavioral activity. A fourth extraction showed no behavioral activity for both organic and aqueous layers. However, the findings of Experiment 3 showed that incubation of the aqueous layer from the third CH2Cl2 extraction in β-glucuronidase can free additional aggression-promoting cues into a subsequent CH2Cl2 extraction. It is concluded that two forms of the aggression-promoting chemosignal are present in bladder urine. One is lipophilic and behaviorally active, whereas the other is conjugated, possessing latent chemosignal properties. 相似文献
66.
67.
R. C. P. Lima-Júnior D. I. M. Sousa G. A. C. Brito G. M. Cunha M. H. Chaves V. S. N. Rao F. A. Santos 《Inflammation research》2007,56(12):487-494
Objective and design: We previously described the visceral antinociceptive property of α, β-amyrin in a mouse model of cystitis induced by cyclophosphamide
(CPM). This study examined the contribution of vanilloid-1 (TRPV1), peripheral NK1 receptors to CPM-evoked nociceptive behaviors
and bladder edema, and its possible modulation by α, β-amyrin.
Methods: The effect of α, β-amyrin (10, 30, and 100 mg/kg, p. o.) and N-acetylcysteine (NAC) on CPM (400 mg/kg, i. p.)-induced cystitis
was studied in mice. Sensory deafferentation was done by a high dose capsaicin. The parameters analysed were: CPM-evoked noxious
behaviors, bladder edema, vascular permeability, and NK1 immunoreactivity. To assess the role of K+
ATP channels in α, β-amyrin effect, animals were pretreated with glibenclamide.
Results: α, β-amyrin (30 and 100 mg/kg) and NAC significantly (p < 0.01) suppressed the visceral pain-related behaviors and NK1 immunoreactivity, but bladder edema was reduced weakly. Glibenclamide reversed the effects of α, β-amyrin. Sensory deafferentation
by capsaicin significantly reduced the nociceptive responses and the NK1 immunoreactivity to noxious stimulation by CPM.
Conclusions: α, β-amyrin attenuates CPM-induced visceral pain and bladder edema by mechanisms that involve, at least in part, a block either
of Substance P release or its receptor function, and partly by opening K+
ATP channels.
Received 13 February 2007; returned for revision 13 April 2007; accepted by G. Geisslinger 14 May 2007 相似文献
68.
D. Kirsten U. Rieger K. H. Schröder A. Böhle H. Magnussen 《Journal of molecular medicine (Berlin, Germany)》1993,71(10):787-790
Summary Immunotherapy using bacille Calmette-Guérin (BCG) has gained increasing acceptance in the management of superficial bladder cancer. Systemic reactions after intravesical instillation of BCG are rare. However, when the therapy is complicated, the lung often becomes involved. Since the pathogenesis of lung infiltrates after immunotherapy is unknown, we report on a patient who developed a lung infiltrate after receiving BCG immunotherapy for bladder cancer. The infectious etiology was established by culture confirmation of a BCG strain in the broncheoalveolar lavage fluid.Abbreviation BCG
bacille Calmette-Guérin 相似文献
69.
A. V. Lagutin 《Bulletin of experimental biology and medicine》1977,84(3):1243-1246
Acute experiments were carried out on cats by a stereotaxic method to identify the morphological formations stimulation of which leads to the development of acute prolapse of the brain. These formations were found to be the lateral hypothalamic area, the zona incerta, zones H1 and H2, the parafascicular, interstitial, and interpeduncular nuclei, and the nucleus of Darkshevich. In response to stimulation of the lateral hypothalamic area, zona incerta, and zones H1 and H2, besides the characteristic histological changes of acute prolapse, signs of edema and swelling of the brain also were found.Department of Human Anatomy, Voroshilovgrad, Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR V. N. Chernigovskii.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 9, pp. 276–279, September, 1977. 相似文献
70.
Stomal prolapse is a common complication of colostomies and, if severe, may affect the timing of the definitive procedure. A simple technique for postreduction bowel fixation without stomal revision is presented. The reduced bowel is attached to the parietal peritoneum using a "U" type suture a few centimeters from the stoma. Two short parallel segments of latex tubing prevent the thread from cutting through. Suture and bolsters are removed when adhesions are established. In one of the four children, a percutaneous cecostomy was employed to connect a prolapse of the entire proximal colon. 相似文献