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61.
Katie Kompoliti Yaping Chu Kathleen M Shannon Jeffrey H Kordower 《Movement disorders》2007,22(11):1630-1633
To date, there is no clinicopathological correlation of adrenal medullary transplant cases in patients with survival beyond a few years. Postmortem examination of a brain from a patient with Parkinson's disease (PD), 16 years after autologous adrenal medullary transplant, was performed using tyrosine hydroxylase (TH) and chromogranin A. The patient experienced a four-year initial improvement in motor function followed by resumption of the progressive nature of her disease that continued until her death. She expired 16 years following grafting. At autopsy, TH stain of the brain revealed severe loss of TH-immunoreactivity in the substantia nigra and Lewy bodies, confirming the diagnosis of PD. The transplant site was identified by the presence of scarring and there was complete absence of any TH staining cells at the site of the transplant. There were few surviving cells staining with chromogranin A. The absence of TH-staining cells in the transplant 16 years after surgery provides further evidence that adrenal medullary transplants do not survive in the long term. 相似文献
62.
63.
星形细胞瘤瘤周水肿区立体定向活检组织的超微结构研究 总被引:1,自引:0,他引:1
目的探讨星形细胞瘤瘤周脑水肿的发生机制。方法对15例星形细胞瘤瘤周脑水肿的宽度进行分级:一级0~20mm、二级21~40mm、三级〉40mm。结合CT平扫及增强扫描的影像,应用立体定向技术,对15例星形细胞瘤瘤体、瘤周水肿区及正常脑组织的活检标本进行电镜观察比较。结果CT增强扫描可强化,瘤周脑水肿明显的病人,其瘤体及瘤周水肿区毛细血管超微结构均有不同程度的改变。毛细血管的分布和结构变化,影响着瘤周水肿区的形态,瘤体毛细血管的明显异常,出现于大范围瘤周水肿区的病例。CT增强扫描无强化,瘤周脑水肿不明显的病人,毛细血管超微结构与正常脑组织相似。结论伴有明显瘤周脑水肿的星形细胞瘤,其瘤体及瘤周水肿区毛细血管超微结构均有不同程度的改变,而瘤周水肿的产生,是瘤体及瘤周水肿区毛细血管超微结构改变共同作用的结果。 相似文献
64.
EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force 总被引:2,自引:0,他引:2
R. Soffietti P. Cornu J. Y. Delattre R. Grant F. Graus W. Grisold J. Heimans J. Hildebrand P. Hoskin M. Kalljo P. Krauseneck C. Marosi T. Siegal C. Vecht 《European journal of neurology》2006,13(7):674-681
The objectives have been to establish evidence-based guidelines and identify controversies regarding the management of patients with brain metastases. The collection of scientific data was obtained by consulting the Cochrane Library, bibliographic databases, overview papers and previous guidelines from scientific societies and organizations. A tissue diagnosis is necessary when the primary tumor is unknown or the aspect on computed tomography/magnetic resonance imaging is atypical. Dexamethasone is the corticosteroid of choice for cerebral edema. Anticonvulsants should not be prescribed prophylactically. Surgery should be considered in patients with up to three brain metastases, being effective in prolonging survival when the systemic disease is absent/controlled and the performance status is high. Stereotactic radiosurgery should be considered in patients with metastases of 3–3.5 cm of maximum diameter. Whole-brain radiotherapy (WBRT) after surgery or radiosurgery is debated: in case of absent/controlled systemic cancer and Karnofsky Performance score of 70 or more, one can either withhold initial WBRT or deliver early WBRT with conventional fractionation to avoid late neurotoxicity. WBRT alone is the treatment of choice for patients with single or multiple brain metastases not amenable to surgery or radiosurgery. Chemotherapy may be the initial treatment for patients with brain metastases from chemosensitive tumors. 相似文献
65.
Claudia Breitkopf Ludwig Suter 《Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete》1995,46(7):502-504
Zusammenfassung
Bei einer 71j?hrigen Frau trat nach R?ntgenweichstrahltherapie an der Nase (Gesamtdosis 28 Gy, Gewebehalbwerttiefe 10,5–11,5
mm) eine ausgepr?gte Strahlenerosion auf. Diese zeigte 5 Wochen nach Ende der Bestrahlung noch keine Tendenz zur Abheilung.
Ursache dieses ungew?hnlichen Verlaufes war ein gleichzeitig bestehender Pemphigus vulgaris. Dieser hatte sich nach der Strahlentherapie,
vermutlich als Folge einer Freisetzung epidermaler Antigene, verschlimmert. Da? der Pemphigus in diesem Fall durch die Bestrahlung
ausgel?st wurde – wie mehrfach in der Literatur berichtet – ist unwahrscheinlich, aber nicht sicher auszuschlie?en.
Eingegangen am 11. April 1994 Angenommen am 10. Juni 1994 相似文献
66.
A separation of the individual latex layers is a known complication of endotracheal armoured tubes manufactured by immersion technique. This can result in herniation into the lumen with obstruction of the tube. Diffusion of nitrous oxide into the inner hernia considerably intensifies the obstruction. This can lead to life-threatening situations. We observed a similar herniation caused by layer separation with subsequent tube obstruction of silicolatex anaesthesia tubes used in paediatric circuit systems. This is caused by manufacturing defects and above all by damage incurred in reprocessing. Therefore it is important to process the tubes carefully. A too-high drying temperature can cause premature layer separation. The tubes should never be processed more than 80 times. Routine examination of the tubes is imperative, especially at the predilection sites for layer separation. 相似文献
67.
BACKGROUND AND PURPOSE: The Doppler waveform patterns of loss of diastolic flow, appearance of retrograde diastolic flow, or no detectable flow in the cerebral arteries suggest significantly abnormal cerebral blood flow (CBF). A retrospective study was performed to show that significantly abnormal CBF alone, without clinical criteria, is not necessarily specific to brain death in the young pediatric population. PATIENTS AND METHODS: Forty-seven pediatric patients, from newborn to 4 years of age, were found to have significantly abnormal CBF, including 7 patients with loss of diastolic flow, 28 with retrograde diastolic flow, and 23 with no detectable cerebral flow on serial Doppler sonographic examinations. Their clinical data and sonographic results were collected and analyzed. RESULTS: Forty-two patients died, a few of whom had only transient improvement of cerebral flow. All of the patients with no detectable cerebral flow expired. Five patients survived with or without sequelae. Their underlying conditions that caused increased intracranial pressure were treated by medical and/or surgical intervention, and diastolic reversal of CBF corrected within 1 day in all 5. CONCLUSIONS: Although no detectable flow is a lethal sign, pediatric patients with loss or reversal of diastolic flow may survive with prompt and effective treatment. Using Doppler ultrasound to diagnose cerebral circulatory arrest should be done with caution in pediatric patients. 相似文献
68.
目的 探讨CT检查对判断新生儿缺氧缺血性脑病 (HIE)预后的价值。方法 对 85例HIE患儿分别在生后 1周内、2周~ 2个月、3~ 6个月、1~ 1 5岁进行CT检查 ;同时在生后12~ 14d进行新生儿行为神经测定 ;在 1~ 1 5岁测定发育商判断预后。结果 生后 1周内CT结果分度为重度者预后不良率为 4 0 9% (9/ 2 2 ) ,为中度者预后不良率为 5 7% (3/ 5 2 ) ;2个月时CT随访结果异常者预后不良率为 6 0 0 % (6 / 10 ) ;CT结果中度且 12~ 14d的NBNA评分≥ 35分与 <35分者的预后差异无显著性 ,CT结果重度且 12~ 14d的NBNA评分 <35分者有 72 7% (8/ 11)预后不良。结论 生后 1周内CT分度及生后 1个月左右随访结果 ,同时结合临床、生后 12~ 14dNBNA评分对判断HIE患儿的预后、制定治疗方案及疗程有重要意义。 相似文献
69.
Protein kinase C (PKC) activity was measured in rat brain with 2 h of middle cerebral artery (MCA) and common carotid artery (CCA) occlusion, using dual autoradiography of [14C]iodoantipyrine (IAP) and [3H]phorbol-12,13-dibutyrate (PDBu). In the ischemic brain, it required more than 120 min of incubation to obtain a plateau in PDBu binding. In contrast, the binding of PDBu in non-ischemic brain reached a plateau with incubation for 60 min. This delay of PDBu binding in the ischemic brain suggests that the affinity of this ligand is reduced due to a change in structure of the cell membrane caused by ischemia. PDBu binding in the ischemic brain increased significantly compared to the non-ischemic brain. This finding provides further evidence that excessive activation of PKC in the ischemic brain may play an important role in ischemic neuronal damage. ©1997 Elsevier Science B.V. All rights reserved. 相似文献
70.
MASATO FUKUDA MD AKINOBU HATA MD SHIN-ICHI NIWA MD KEN-ICHI HIRAMATSU MD MASAFUMI YOKOKOJI MD SEIKI HAYASHIDA AM KENJI ITOH DENG KAZUYUKI NAKAGOME MD AKIRA IWANAMI MD 《Psychiatry and clinical neurosciences》1996,50(2):85-88
Abstract A female patient exhibiting functional hearing loss in her left ear demonstrated reduced amplitude of P3 component in event-related potentials (ERP) to left monaural stimulation, with preserved N1 and N2 components to stimulation of either ear. This result suggested that stimuli in the affected ear were conducted successfully up to the auditory cortex but that further processing in higher brain regions was 'repressed'. Event-related potential examination for such hysterical disorders could be useful in clarifying their brain mechanism and offer a useful diagnostic clue to its nature. 相似文献