Multicystic encephalomalacia after first-trimester intrauterine fetal death in monochorionic twins

Multicystic encephalomalacia occurs in approximately 20% of surviving cotwins after second- and third-trimester intrauterine fetal death of one twin in monochorionic pregnancies. We report a case of multicystic encephalomalacia after the demise of a cotwin in the first trimester diagnosed by magnetic resonance imaging and confirmed pathologically.     

Radiofrequency ablation in a monochorionic twin discordant for fetal anomalies

Radiofrequency ablation is a minimally invasive technique that has been used in selective reduction of acardiac twins. We report a case in which radiofrequency ablation was used to selectively reduce a monochorionic twin discordant for an abnormality.     

Cardiac and other malformations in parapagus twins

Introduction Conjoined twins occur in one in 50–200,000 live births and approximately 75% of all cases are thoracopagus twins. Parapagus conjoined twins are rare and are not included in many review articles.Case report The cardiovascular system of a male parapagus (dicephalus, tetrabrachius, dipus) conjoined twins was studied. Twin B had bilateral bilobed lungs and a normal heart, while bilateral trilobed lungs and right isomerism was found in twin A. They shared a diaphragm and an abdominal cavity. There were two complete heads on two necks, two thoraxes, one abdomen, four arms, two legs, two complete vertebral columns, a single pelvis, and severe cardiac anomalies.     

Monozygotic Twins and Triplets in Association with Blastocyst Transfer

PURPOSE: To compare the incidence of monozygotic twins following blastocyst versus day-3 embryo transfer (ET). METHODS: A retrospective analysis of the outcome of assisted reproductive technology (ART) cycles utilizing blastocyst ET during 1999-2000 was compared to a similar group of patients undergoing day-3 ET during 1997-1998. RESULTS: Blastocyst ET was used in 75 cycles with 2.0 +/- 2 embryos transferred. The comparison group consisted of 90 cycles with day-3 ET and 3.0 +/- 2 embryos transferred. CONCLUSIONS: High pregnancy rates are maintained with blastocyst ET even though fewer embryos are transferred. The rate of monozygotic twins is higher with blastocyst ET than with day-3 ET. This increase may partially negate the benefit of reduced high-order multiple gestations attributed to blastocyst ET.     

Identical reconstitution after bone marrow transplantation in twins who received fresh and cryopreserved grafts harvested at the same time from their older brother

We report here the reconstitution after bone marrow transplantation (BMT) in identical infant twins with acute myelogenous leukemia (AML). They were diagnosed at 8 and 9 months of age. Complete remission was induced after two courses of chemotherapy. After four and five courses of chemotherapy, respectively, they received BMT at 2-month interval from the same HLA-identical older brother. The total dose of marrow nucleated cells (NC) harvested was 77.7 x 10(8). The first patient was transplanted with half of the total dose of NC. The remaining cells were cryopreserved without the use of a programmed freezer and transplanted into the second patient 2 months later. The number of days for neutrophil (>0.5 x 10(9)/L), platelet (>50 x 10(9)/L), and reticulocyte (>1%) recovery were, respectively, 15, 21, and 14 in the first case and 12, 21, and 15 in the second case. The clinical courses after BMT were uneventful in both cases, except for mild acute GVHD, and complete remission has been maintained >4 yr with full recovery of immune and marrow function. Based on the results in these cases, we confirmed that marrow cells that have been cryopreserved without the use of a programmed freezer could reconstitute immune and marrow function as well as non-cryopreserved cells.     

Anaesthetic experiences in three sets of conjoined twins in King Chulalongkorn Memorial Hospital

We describe the anaesthetic management for magnetic resonance image scanning, angiography and surgical operations in three sets of conjoined twins (ischiopagus, throracopagus and pygopagus) in King Chulalongkorn Memorial Hospital during 1996-2002. The anaesthetic technique and associated problems are summarized.     

Advanced “tactile” medical imaging for separation surgeries of conjoined twins

Background Understanding the anatomy of conjoined twins is difficult because of the rarity of this congenital malformation and the scarcity of reported cases in medical literature.New technology Advances in radiologic imaging, computer modeling, and sophisticated manufacturing techniques enable medical imaging datasets to be translated into accurate, solid, life-size models. These models, which can be designed to include various combinations of anatomical features revealed by established imaging modalities, are important for pre-surgical assessments and planning, as well as for reference during the actual operative procedure. In addition, they provide a valuable basis for communication between the groups of specialists who are involved in these cases.Case studies This article will describe the advances in technology behind this process and illustrate its value in two cases of craniopagus twins.     

Ethics and conjoined twins

Introduction

The birth of live conjoined twins in a community can draw considerable attention to the appropriate ethical issues.

Discussion

The management requires the skills of a multi-disciplinary team of clinicians who have seldom faced the challenge. The team leader must draw together principles of a medical, social, cultural, religious and legal nature in reaching the best outcome. Often the basic question is whether one child should die or both? At times the question is raised whether it is justifiable to sacrifice one life to save the other. In these days of high technology, surgeons can be tempted to go a bridge too far. In reaching this decision there can be numerous hidden conflicts of interest. Increasingly the final decision needs to be made and approved by the courts so as to protect the rights of the twins and to ensure surgical intervention is not an unlawful act.     

Separation of craniopagus twins: the Brisbane experience

Introduction There are many problems facing the neurosurgeon when separating craniopagus twins. The condition is rare, with an incidence of 1 in 2.5 million births. As such there is a paucity of information in the literature regarding strategies for separation. Survival rates Over the last 20 years, there has been a gradual improvement in survival rates due to a combination of improved imaging, surgical/anaesthetic techniques and postoperative care. Currently, survival rates following surgery are at 50–60%. More information regarding this condition is needed to make surgical separation a safer event.Aim The aim of this article is to discuss the preoperative work-up, technical details of surgery, postoperative care and lessons learned with respect to the separation of craniopagus twins.     

The embryology of conjoined twins

Introduction Attention is drawn to the spontaneous incidence of twinning, both dizygotic and monozygotic in different mammalian species. Conjoined twinning, however, only arises when the twinning event occurs at about the primitive streak stage of development, at about 13–14 days after fertilisation in the human, and is exclusively associated with the monoamniotic monochorionic type of placentation. It is believed that the highest incidence of conjoined twinning is encountered in the human. While monozygotic twinning may be induced experimentally following exposure to a variety of agents, the mechanism of induction of spontaneous twinning in the human remains unknown. All agents that are capable of acting as a twinning stimulus are teratogenic, and probably act by interfering with the spindle apparatus.Discussion The incidence of the various types of conjoined twinning is discussed. Information from the largest study to date indicates that the spontaneous incidence is about 10.25 per million births. The most common varieties encountered were thoraco-omphalopagus (28%), thoracopagus (18.5%), omphalopagus (10%), parasitic twins (10%) and craniopagus (6%). Of these, about 40% were stillborn, and 60% liveborn, although only about 25% of those that survived to birth lived long enough to be candidates for surgery. Conjoined twinning occurs by the incomplete splitting of the embryonic axis and, with the exception of parasitic conjoined twins, all are symmetrical and the same parts are always united to the same parts. Fusion of monozygotic twins is no longer believed to be the basis of conjoined twinning. Accounts are provided of the anatomical features of each of the commonly encountered varieties.