Propriospinal myoclonus after treatment with ciprofloxacin.

The clinical and electrophysiological features of a truncal myoclonus in a 55-year-old man are described. The electromyographic characteristics point toward propriospinal myoclonus. It is suggested that a myoclonic generator was released after use of ciprofloxacin, by antagonising the gamma-aminobutyric acid metabolism.     

AmpC酶在主要肠杆菌科和非发酵菌中的携带率及耐药性

目的：调查主要肠杆菌科细菌和非发酵菌产AmpC酶和ESBLs的状况及对常用抗菌药物的耐药性，指导临床合理用药。方法：常规培养分离细菌，应用VTTEK微生物自动分析仪和API鉴定系统鉴定病原菌；药敏试验采用K-B纸片扩散法；AmpC酶检测采用三维试验法；ESBLs检测采用双纸片确认试验。结果：主要肠杆菌科细菌产AmpC酶和ESBLs的阳性率分别为18．9％，52．8％，其中以大肠杆菌、肺炎克雷伯、产酸克雷伯、阴沟肠杆菌为主，同时产2种酶的菌株占15．4％；绿脓杆菌产AmpC酶和ESBLs酶的阳性率分别为18．2%，，42．0％，同时产2种酶的菌株占13．6％；不动杆菌的产酶率均在8．0％以下,产酶菌的耐药率高于非产酶菌，除绿脓杆菌外，产AmpC酶菌株的耐药率高于产ESBLs菌株．主要肠杆菌科细菌对泰能(IMP)的敏感性为99．5%，而对舒普深(CPZ)的耐药率平均为13．8％；非发酵菌对IMP，马斯平(FEP)、CPZ的耐药率平均分别为20．4％，44．3％，18．6％.结论：主要肠杆菌科细菌的产酶率高于非发酵菌，产AmpC酶的菌株已近20．0%，应引起临床的高度重视；绿脓杆菌产ES-BLs的菌株也较高，也应该加强监控．对产酶菌引起感染的治疗应根据细菌药敏试验结果，合理选择有效的抗菌药物联合治疗；对重症感染患的治疗应根据药敏试验结果重点应用泰能或舒普深治疗。     

Study on Tongkuaixiao Babu plaster in treating cancer pain

Objective: To explore the efficacy of Tongkuaixiao Babu plaster (TKXBBP) in treating cancer pain.Methods: In the clinical observation, sixty-five patients with moderate or severe cancer pain were randomly divided into two groups: 32 in the treated group (TKXBBP group) and 33 in the control group (Bucinnazine group). The therapeutic effects in relieving pain, improving quality of life (QOL), and the rate of satisfaction the patients felt of the two groups were compared respectively. Results: TKXBBP was effective in treating cancer pain. There wasn’t any statistically significant difference in total effective rate (P>0.05), but the statistical difference was significant in obvious remission rate (P<0.05) between the treated and control group, and the effect on serious pain shown in the treated group was better than that of the control group (P<0. 05). The difference in the initiation time of relieving cancer pain was insignificant (P>0.05), while in the remission period, the treated group showed its treatment was obviously superior to that of the control group (P<0.05). TKXBBP showed better effect in the improvement of QOL (P<0.05) and satisfaction rate, with significant difference between the treated and the control groups (P<0.01).Conclusion: TKXBBPs effect in treating cancer pain was obvious, its application was safe and convenient. It was shown that the external treatment with this kind of Chinese medicine had great advantage in treating cancer pain.     

骨骼肌钝挫伤后愈合质量的肌电评价

目的 :观察大鼠骨骼肌钝挫伤后 ,不同干预方法对骨骼肌修复过程中肌电信号的影响 ,研究肌电图在骨骼肌损伤愈合过程中的评价作用。方法 :10 8只雄性SD大鼠 ,利用自制的重物坠落打击装置造成右侧腓肠肌钝挫伤。随机分成 3组 ,即胰岛素样生长因子 - 1(IGF - 1)组、中药组和自然愈合组 ,分别于损伤局部注射IGF - 1、黄芪丹参注射液、不作处理。于伤后第 2、5、7、10、14、2 1、2 8、35、5 6天观察并比较双侧腓肠肌的肌电图变化 ,记录纤颤电位和正尖波等自发活动 ,分析复合肌肉动作电位 (CMAP)并测量其潜伏期和波幅 ,观察伤后CMAP的变化。结果 :(1)各组大鼠均于伤后第 2～ 5天出现纤颤电位和正尖波 ,约至第 7～ 10天达到高峰 ,然后逐渐减少。以IGF - 1组最早消失 ,中药组次之。 (2 )各组大鼠的伤侧肌电图CMAP中的潜伏期逐渐缩短 ,波幅逐渐增高。以IGF - 1组最快 ,中药组次之 ,自然愈合组最慢。 (3)伤后第 8周 ,IGF - 1组和中药组大鼠损伤侧CMAP波幅接近正常 ,自然愈合组则显著低于其它两组。结论 :(1)肌电图检测证实 ,IGF - 1和黄芪丹参注射液均具有促进骨骼肌损伤愈合的作用 ,但以IGF - 1的作用更明显。 (2 )损伤肌肉局部肌电信号的变化 ,可以用来评价损伤骨骼肌的修复进程和愈合质量     

Is dietary counselling effective in increasing dietary calcium,protein and energy intake in patients with osteoporotic fractures? A randomized controlled clinical trial

To determine the feasibility of increasing the calcium, protein and calorie intake of osteoporotic fracture patients by repeated dietary counselling delivered by a dietitian, a randomized controlled trial was conducted. Among 189 patients presenting with osteoporotic fractures to an Orthopaedics and Traumatology Department of a large regional hospital, 98 patients were randomized to the intervention group and 91 were randomized to the control group (with usual care). Intervention group received three sessions of dietary counselling with tailored made recommendations over a period of 4 months, while the control group only received dietary assessment and pamphlets on the prevention of osteoporosis. Almost all subjects in both intervention and control groups had calcium intake below the recommended level of 1000 mg at baseline. Half and 60% of subjects in both groups had total energy and protein intake below recommended levels respectively. The mean weights of control and intervention groups at baseline were 51.5 and 50.9 kg respectively, while the body mass index (BMI) were 22.6 (kg m(-2)) and 22.6 (kg m(-2)) respectively. After dietary intervention, significant increase of intake was seen in calcium intake (P = 0.0095 by t-test) in the intervention group. No significant increase was seen in protein or calorie intake. No significant change was observed in the body weight or BMI although there was a positive trend in the intervention group for all these parameters. We concluded that there was general malnutrition in Chinese elderly who presented with osteoporotic fractures. Dietary calcium could be increased by repeated professional dietary counselling. Future studies with longer duration and more objective clinical outcomes will be helpful to further demonstrate the long-term effects of dietary intervention on osteoporosis and other chronic diseases.     

中医脊柱手法与西医手法的对比研究

东西方在脊柱手法方面都有很多研究，近年来研究进展迅速，取得了一些进步，为临床治疗因脊柱原因引起的痛症提供了一种新的有效方法。在西方手法医学的基础上，认真研究短杠杆微调手法，对颈椎、腰椎手法进行改进，通过临床实践，手法实用效果良好。     

Erythema multiforme during cytomegalovirus infection and oral therapy with terbinafine: a virus–drug interaction

The authors report a case of erythema multiforme in a 32-year-old woman who was also taking oral terbinafine for an onychomycosis. The patient data analysis showed serological positivity for cytomegalovirus (IgM and IgG) and hepatitis C virus and serological titre of antinuclear antibody was elevated. After a brief review of the literature the authors propose the possibility of virus-drug interaction as a model of adverse drug reactions.     

Evaluation ofin vitro drug screening leads using experimental models of human ovarian cancer

Summary Five compounds which were identified as potential new anticancer drugs inin vitro screening with the human tumor colony forming assay were selected for further evaluation usingin vitro andin vivo models of human ovarian cancer. Three of five compounds were found to inhibitin vitro colony formation of ovarian cancer cell lines derived from both untreated and combination chemotherapy refractory patients. One compound was also found to prolong survival in a human ovarian carcinoma xenograft model system. This compound, chloroquinoxaline sulfonamide, was selected for development and has shown preliminary indication of activity in phase I clinical testing.