不同性别高敏C-反应蛋白与代谢综合征关系

目的探讨江苏省男、女性中高敏C-反应蛋白（hs-CRP）度与代谢综合征（MS）的关系及其影响因素。方法采用横断面研究的方法。在江苏省多代谢异常和代谢综合征综合防治研究基线调查资料中选择1039名男性和1291名女性作为研究对象，测量研究对象的身高、体重、腰围、血压，计算体质指数（BMI）；检测血清中hs-CRP、血脂、血糖、高密度脂蛋白、低密度脂蛋白。采用Logistic回归分析影响男、女性hs-CRP浓度与MS的关系。结果女性随着hs-CRP浓度的增加患MS的危险增加（P〈0．01）。而男性hs-CRP浓度与MS的关系则不明显（P=0．08）。女性中这种联系在调整年龄、吸烟、饮酒、高血压家族、糖尿病家族史后仍存在，但在进一步调整体质指数后这种关系消失。结论BMI是影响hs-CRP浓度的主要因素。女性随着hs-CRP浓度的升高，患MS的危险也相应增加。而男性中hs-CRP浓度与MS的联系则不显著。     

Influences of V5-epitope tag on the metabolic activation of AFB1 by human cytochrome P450 2A13

INTRODUCTION A flatoxin B1 (AFB1) , which is produced by Aspergillus flavus and Aspergillus parasitus, is a potent carcinogen in human and animals. Al- though AFB1 is best known as a liver carcinogen, it also induces lung tumors in animals and epidemio- logical studies show a positive association between human lung cancer occurrence and inhalation expo- sure to AFB1-containminated grain dust. As most of environmental carcinogens, metabolic activation cat- alyzed by cytochrome P450 (C…     

代谢综合征患者胰岛素抵抗与游离脂肪酸的变化及非诺贝特的干预

目的观察代谢综合征（MS）患者胰岛素抵抗（IR）和游离脂肪酸（FFA）的变化及非诺贝特对其影响。方法入选30例MS患者，给予非诺贝特治疗12周，采用放射免疫法和酶比色法测定治疗前后空腹血清胰岛素和FFA水平及空腹血糖、血脂，计算IR指数。另选30例正常人作为对照。结果MS患者HOMA—IRI和FFA较正常人明显升高（P分别〈0．01和〈0．05）。经非诺贝特干预后，高密度脂蛋白胆固醇明显升高（P〈0．01），甘油三酯、IR指数、FFA均明显下降（P分别〈0．01，〈0．01及〈0．05）。结论非诺贝特能够明显降低MS患者血清甘油三酯水平，升高高密度脂蛋白胆固醇水平，改善IR，其机制可能与降低血清FFA浓度有关。     

Mitochondrial DNA Copy Number Is Associated With Treatment Response and Cognitive Function in Euthymic Bipolar Patients Receiving Valproate

BackgroundBipolar disorder (BD) is associated with cognitive impairment and mitochondrial dysfunction. However, the associations among mitochondrial DNA copy number (MCN), treatment response, and cognitive function remain elusive in BD patients.MethodsSixty euthymic BD patients receiving valproate (VPA) and 66 healthy controls from the community were recruited. The indices of metabolic syndrome (MetS) were measured. Quantitative polymerase chain reaction analysis of blood leukocytes was used to measure the MCN. Cognitive function was measured by calculating perseverative errors and completed categories on the Wisconsin Card Sorting Test (WCST). The VPA treatment response was measured using the Alda scale.ResultsBD patients had significantly higher MCN, triglyceride, and C-reactive protein (CRP) levels, waist circumference, and worse performance on the WCST than the controls. Regression models showed that BD itself and the VPA concentration exerted significant effects on increased MCN levels. Moreover, the receiver operating characteristic curve analysis showed that an MCN of 2.05 distinguished VPA responders from nonresponders, with an area under the curve of 0.705 and a sensitivity and specificity of 0.529 and 0.816, respectively. An MCN level ≥2.05 was associated with 5.39 higher odds of being a VPA responder (P = .006). BD patients who were stratified into the high-MCN group had a higher VPA response rate, better WCST performance, lower CRP level, and less MetS.ConclusionsThe study suggests a link between the peripheral MCN and cognitive function in BD patients. As an inflammatory status, MetS might modulate this association.     

Catechins as a Potential Dietary Supplementation in Prevention of Comorbidities Linked with Down Syndrome

Plant-derived polyphenols flavonoids are increasingly being recognized for their medicinal potential. These bioactive compounds derived from plants are gaining more interest in ameliorating adverse health risks because of their low toxicity and few side effects. Among them, therapeutic approaches demonstrated the efficacy of catechins, a major group of flavonoids, in reverting several aspects of Down syndrome, the most common genomic disorder that causes intellectual disability. Down syndrome is characterized by increased incidence of developing Alzheimer’s disease, obesity, and subsequent metabolic disorders. In this focused review, we examine the main effects of catechins on comorbidities linked with Down syndrome. We also provide evidence of catechin effects on DYRK1A, a dosage-sensitive gene encoding a protein kinase involved in brain defects and metabolic disease associated with Down syndrome.     

胎龄小于34周早产儿骨强度影响因素分析

目的分析胎龄小于34周早产儿骨骼早期发育的影响因素,为早产儿代谢性骨病的早期预防提供依据。方法选取2017年5月-2018年12月在苏州市立医院出生胎龄<34周的早产儿224例,于矫正3月龄进行左侧胫骨中段超声骨强度测定。通过本院住院系统与儿童保健早产儿管理档案搜集与骨骼发育相关的资料。结果 224例早产儿矫正3月龄超声骨强度Z值为-1.4(-0.6,-2.0),其中,79例(35.27%)超声骨强度值正常,43例(19.20%)轻度骨强度不足,38例(16.96%)中度骨强度不足,64例(28.57%)重度骨强度不足。女婴(OR=4.184,95%CI:1.876～9.329,P<0.001)、出生胎龄≤31周(OR=2.854,95%CI:1.282～6.352,P=0.010)、新生儿静脉营养(全肠外)≥7 d(OR=3.180,95%CI:1.480～6.832,P=0.003)、新生儿咖啡因使用≥10 d(OR=5.673, 95%CI:1.820～17.686,P=0.003)、住院期间碱性磷酸酶(ALP)峰值≥400 U/L(OR=2.796,95%CI:1....     

Comparing Digital Therapeutic Intervention with an Intensive Obesity Management Program: Randomized Controlled Trial

In this study, we evaluated whether the digital program Vitadio achieves comparable results to those of an intensive in-person lifestyle intervention in obesity management. This is a 12-month prospective, randomized controlled trial. Obese patients with insulin resistance, prediabetes or type 2 diabetes were included. The intervention group (IG) used Vitadio. The control group (CG) received a series of in-person consultations. Body weight and various metabolic parameters were observed and analyzed with ANOVA. The trial is ongoing and the presented findings are preliminary. Among 100 participants (29% men; mean age, 43 years; mean BMI, 40.1 kg/m²), 78 completed 3-month follow-up, and 51 have completed the 6-month follow-up so far. Participants significantly (p < 0.01) reduced body weight at 3 months (IG: −5.9 ± 5.0%; CG: −4.2 ± 5.0%) and 6 months (IG: −6.6±6.1%; CG: −7.1 ± 7.1%), and the difference between groups was not significant. The IG achieved favorable change in body composition; significant improvement in TAG (−0.6 ± 0.9 mmol/l, p < 0.01), HDL (0.1 ± 0.1%, p < 0.05), HbA1c (−0.2 ± 0.5%, p < 0.05) and FG (−0.5 ± 1.5 mmol/l, p < 0.05); and a superior (p = 0.02) HOMA-IR reduction (−2.5 ± 5.2, p < 0.01). The digital intervention achieved comparable results to those of the intensive obesity management program. The results suggest that Vitadio is an effective tool for supporting patients in obesity management and diabetes prevention.     

心血瘀阻证大鼠血浆代谢网络模型分析

目的：探讨心血瘀阻证大鼠血浆代谢网络模型。方法：代谢通路分析采用KEGG 数据库,代谢产物分子注释、相关的酶或转运蛋白及其相关性质分析采用HMDB 数据库,代谢网络模型可视化采用metPA 网络软件。结果：9 个代谢产物参与了15 条代谢通路,其中泛酸盐和CoA 生物合成、丙酸代谢、不饱和脂肪酸生物合成通路影响值P＜0.05。结论：泛酸盐和CoA 生物合成、丙酸代谢、不饱和脂肪酸生物合成通路参与大鼠心血瘀阻证的病理过程。     

大豆异黄酮对代谢综合征大鼠主动脉内皮细胞功能影响的实验研究

目的：观察大豆异黄酮对膳食诱导代谢综合征大鼠血管内皮功能的影响。方法：采用高脂高糖高盐饲料喂养建立大鼠MS模型。测量体重、血压、空腹血糖、血清胰岛素、血脂、HOMA-IR,筛选MS成模大鼠,予大豆异黄酮高、低剂量灌胃4周,以二甲双胍作为阳性药对照,检测主动脉H染色、血清vWF和eNOSmRNA表达情况。结果：模型组大鼠主动脉组织病理改变明显,SI高剂量组和二甲双胍组主动脉病理改变有不同程度改善。SI高剂量组和二甲双胍组体重、血糖、血清胰岛素和胰岛素抵抗指数较模型组均下降（P〈0.05）;仅SI高剂量组血压下降（P〈0.05）;SI高剂量组大鼠TG、TC和LDL-C水平均显著下降（P〈0.05）;三组大鼠血清vWF水平均降低（P〈0.05）,SI高剂量优于低剂量。在eNOS mRNA表达上SI高剂量组和二甲双胍组均较模型组增高（P〈0.05）。结论：大豆异黄酮能改善MS大鼠主动脉组织结构,降低血清vWF水平,上调主动脉eNOS mRNA表达发挥主动脉内皮保护作用。     

诱导子对丹参有效成分次生代谢的诱导与调控

诱导子被认为是提高药用植物次生代谢产物最有效的方法之一,为当前研究的热点.生物和非生物诱导子对丹参有效成分次生代谢具有诱导和调控作用.作者介绍了诱导子对丹参的诱导、调控机制等方面的研究进展.