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251.
Angelo Passerini Liliana Strada Marina Grisoli Maurizio Sberna Maria Grazia Bruzzone 《Child's nervous system》1990,6(1):33-36
The spin-echo procedure is the basic technique in a magnetic resonance (MR) study (the magnetization vector is flipped by 90° onto the ortogonal plane to the main magnetic field). Very soon after the MR procedure was developed, it was pointed out how important it is to achieve the needed contrast with shorter repetition times (TRs) to reduce the imaging time. Recently, fast imaging techniques have been introduced (partial flip angles, short TRs, and the lack of 180° radiofrequency pulses to refocus the spins are their main characteristics; the spins are refocused by the application of a gradient reversal technique). These techniques are particularly needed in pediatric neuroradiology, where the examination time must be as short as possible. At present, partial flip-angle techniques are almost completely replacing the conventional spin-echo procedure, but the variations in flip angle could result in a change in contrast. For these reasons, conventional spin-echo techniques may still be useful in a routine MR study.Presented at the 11th Meeting of the European Society for Paediatric Neurosurgery, Naples 1988 相似文献
252.
Alexander Mülsch Markus Hecker Petr I. Mordvintcev Anatoly F. Vanin Rudi Busse 《Naunyn-Schmiedeberg's archives of pharmacology》1993,347(1):92-100
Summary The molecular mechanism(s) underlying the vasodilator activity of CAS 936 (3-(cis-2,6-dimethylpiperidino)-N-(4-methoxybenzoyl)-sydnonimine) and its metabolites 3-(cis-2,6-dimethylpiperidino)-sydnonimine (C87 3754) and N-(cis-2,6-dimethylpiperidino)-N-nitroso-2-aminoacetonitril (C873786) was investigated. These compounds were tested for their relaxant activity in isolated rabbit arterial segments, activation of purified soluble guanylyl cyclase and release of nitric oxide (NO) in vitro and in vivo. C873754 and C873786 inhibited the noradrenalin-induced contraction and increased the cyclic GMP content of endothelium-denuded rabbit aortic and femoral segments, whereas CAS 936 was without effect. Similarly, both metabolites, but not CAS 936, activated purified soluble guanylyl cyclase (EC50 about 30 M) and released NO in buffered aqueous solutions, as detected by electron spin resonance (esr) spectrometry. Both in vitro and in vivo an accumulation of NO was detected by esr spectrometry in vascular tissues exposed to the metabolites of CAS 936, whereas a significant release of NO from CAS 936 was only detected in the isolated rabbit liver, but not in vascular tissue. It is conceivable, therefore, that the metabolites of CAS 936 appearing in the systemic circulation after hepatic biotransformation induce vasodilatation by release of NO and activation of soluble guanylyl cyclase in vascular smooth muscle. Moreover, the activation of soluble guanylyl cyclase in vitro by the metabolites of CAS 936 was significantly enhanced by co-incubation with certain particulate fractions from bovine aortic endothelial and smooth muscle cells. Thus, an enzymic release of NO from these metabolites in addition to their spontaneous decomposition may play a significant role for their vasodilator activity in vivo.Correspondence to A. Mülsch at the above address 相似文献
253.
Masayuki Takeda Yasushi Katayama Toshiki Tsutsui Hitoshi Takahashi Kazuhide Saito Shotaro Sato Tatsuhiko Yuasa Takeo Kuwabara 《Urological research》1993,21(3):193-197
Summary
31P nuclear magnetic resonance (NMR) spectroscopy of the in situ rat kidney was performed by a surface coil method, and the effects of ischemia and furosemide infusion were assessed.31P NMR spectra of the kidney subjected to 30 min of ischemia returned completely to the pre-ischemic level after 60 min of reperfusion. But the31P NMR spectra after 60 min of ischemia did not recover, even after 120 min of reperfusion. Levels of -ATP and inorganic phosphate (Pi) decreased and the chemical shift of Pi increased after intravenous infusion of furosemide. This increase in chemical shift might signal an alkalotic change in intracellular pH. Furosemide infusion prior to ischemia is thought to protect the kidney from injury induced by 60 min of warm ischemia. The chemical shift of Pi returned to the pre-ischemic level earlier than -ATP and Pi. In conclusion, according to the findings of31P NMR spectroscopy, furosemide infusion prior to ischemia may be effective in protecting the kidney against ischemic injury. But the change in Pi peak and the causes of the dissociation of Pi and -ATP should be examined further. 相似文献
254.
Kurata M 《Journal of anesthesia》1993,7(3):325-333
31P and 23Na nuclear magnetic resonance (NMR) spectroscopy was employed to study the dynamic changes in intracellular high-energy phosphates and sodium during 15min of forebrain ischemia and recirculation in in vivo rat brain. In the presence of the shift reagent Dysprosium triethylenetetramine-N,N,N,N,N,N-hexaacetic and [Dy(TTHA)], the sodium peak separated into two peaks, unshifted and shifted. During 15min of ischemia, the unshifted sodium peak decreased and the shifted sodium peak increased. With recirculation, the unshifted and the shifted sodium peaks returned to the preischemia level within 10min, but the shifted one increased during 30–60min. Intracellular high-energy phosphates and intracellular pH (pHi) decreased during 15min of ischemia and returned to the preischemia levels within 20min of recirculation. We conclude that the decrease in unshifted sodium peak during ischemia is due to the decrease in subarachnoid sodium and the cellular influx of interstitial sodium would be minimum. The increase in shifted sodium peak during ischemia is considered to be due to the dilatation of cerebral blood vessels and the increase in interstitial sodium which was transported from subarachnoid space.(Kurata M: 31P and 23Na nuclear magnetic resonance study on forebrain ischemia in rats with shift reagent Dy(TTHA). J Anesth 7: 325–333, 1993) 相似文献
255.
Deuterium chemical shift imaging for the estimation of cerebral perfusion in rabbit infarction model
In order to develop a new technique for the measurement of local cerebral blood flow (CBF), the deuterium chemical shift imaging (2H-CSI) technique, an application of in vivo nuclear magnetic resonance (NMR), was used for the estimation of cerebral perfusion in rabbit infarction model. The 2H chemical shift images of rabbit brain were obtained every 30 seconds before and after intravenous injection of deuterated saline. The changes in 2H NMR signal intensity documented that the cerebral perfusion in the damaged area due to infarction decreased obviously compared to that in the intact area. These findings indicate that the 2H-CSI technique can be applied to the measurement of local CBF. The readily availability and limited toxicity of deuterated water may make possible to use this method in clinical cases.(Kito K, Arai T, Mori K, et al.: Deuterium chemical shift imaging for the estimation of cerebral perfusion in rabbit infarction model. J Anesth 7: 447–453, 1993) 相似文献
256.
257.
利用磁共振定量测定海马结构体积 总被引:3,自引:0,他引:3
目的:应用磁共振(MRI)测定颞叶癫痫(TLE)患者,非TLE患者及正常人的海马结构(HF)体积。讨论该方法在确定TLE致痫灶中的价值。方法:用MRI对13例TLE患者,17例非TLE患者及37例正常人作为脑干长轴平行的倾斜冠状位扫描,SE序列T1加权像,测量HF的体积。采用正常人HF体积的正常范围及左右两侧HF体积的差值的正常范围对TLE患者可能存在的海马硬化进行定位定侧。结果:正常人HF的体积范围:右侧为1.95~3.68cm^3,左侧为1.93~3.61cm^3。TLE组有7例患者的HF体积缩小,其中2例为双侧萎缩,而非TLE组无一例HF体积缩小。结论:利用MRI定量测定HF技术对TLE患者可能存在的海马萎缩(HA)的定位定侧有较高的敏感性,比目测读片敏感,能提高TLE患者HA的检出率。 相似文献
258.
目的:分析和研究强直性脊柱炎的临床X线检查诊断方法,X线分级、分期的表现及在诊断中的重要性,方法:对80例强直性脊柱炎患者进行X摄片分级,分期,结合血沉(ESR),C-反应蛋白(CRP)和HLA-B2检查诊断。并进行统计学分析。结果:90%患者HLA-B2阳性,60%血沉增快,骶髂关节和髋关节片以2级改变为主,腰椎病变以早、中期X线病变者较多。结论:强直性脊柱炎以青壮年男性为多见,HLA-B2阳性 相似文献
259.
确定游离羟基碳苷的结构和苷键的构型。方法 :以核磁共振谱 (氢谱 ,碳谱 ,氢氢相关谱等 )为主 ,辅以其它波谱数据推断。结果 :证实了所合成的五个游离羟基碳苷a~e均为 β 吡喃构型。 结论 :在无对照品的情况下采用多种波谱数据直接确证游离羟基碳苷的结构和构型是可行的。 相似文献
260.
目的探讨螺旋CT(SCT)和MRI对主动脉瘤的诊断价值。方法25例主动脉瘤,13例行MRI检查,12例行SCT及三维重建技术检查。三维重建方法采用表面阴影显示法(SSD)、最大密度投影(MaxIP)及多层面重建法(MPVR)。结果13例主动脉夹层MRI和SCT均较好显示主动脉夹层内膜片和真假腔,SCT显示内膜破口5例,MRI无一例显示;SCT及三维重建较好地显示了主动脉夹层的内膜撕裂的范围、真性主动脉瘤(TAA)瘤壁的厚度及钙化、附壁血栓的情况及与邻近大血管分支的关系。结论SCT及三维重建技术的联合应用较低场MRI更能明确主动脉瘤的病变,对帮助和指导手术更具有价值。 相似文献