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《Scandinavian journal of gastroenterology》2013,48(6):522-526
The arterial ketone body ratio (acetoacetate to β-hydroxybutyrate) was measured in 15 patients with chronic liver disease before and after the infusion of anticancer drugs or embolic agents (gelatin sponge or iodized oil) into the hepatic artery. The arterial ketone body ratio decreased after hepatic angiography and decreased further at 15 min after infusion therapy. When the arterial ketone body ratio decreased to 1.0 or less on at least one occasion after infusion therapy, the ratio after hepatic angiography was always 1.35 or less. Such patients developed marked systemic symptoms like fever and severe liver dysfunction. Ascites also developed in three patients in whom the arterial ketone body ratio was reduced to 0.7 or less at 24 h after infusion therapy. The arterial ketone body ratios improved at 3–7 days after infusion therapy. In the seven patients treated with gelatin sponge embolization, the ratio at 3–7 days after therapy was actually higher than that before angiography. 相似文献
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Harunobu Sato Tetsuya Tsukamoto Yoshihisa Mizuno Tomoaki Ichikawa Yoshihito Kotani Katsuyuki Honda Kouhei Hatta Makoto Kuroda 《Digestive endoscopy》2014,26(6):749-751
Malakoplakia in the gastrointestinal tract is rare in healthy young people without underlying disease. Sufficient tissue is required for accurate diagnosis. We describe a malakoplakia that developed in a healthy young woman and was treated by endoscopic mucosal resection (EMR). A 40‐year‐old woman with a history of taking oral contraceptives until one year earlier was referred to our hospital with anal bleeding and constipation. A colonoscopy carried out at our another hospital 18 months earlier disclosed no abnormal findings. Colonoscopy at presentation revealed a yellowish‐white tumor, 5 mm in diameter, in the rectum. The lesion was slightly protruded and had a smooth flat surface, without erosion or ulceration. EMR was carried out for a definitive diagnosis. Histopathological examination showed that the tumor contained granular histiocytes, positive for CD68 and negative forcytokeratin (AE1/AE3). Several histiocytes contained intracytoplasmic round bodies (Michaelis–Gutmann bodies), which reacted positively with periodic acid‐Schiff and calcium (Von Kossa) stains. Intracytoplasmic Escherichia coli (von Hansemann bodies) were identified by Giemsa staining. Based on these results, the tumor in the rectum was diagnosed as a malakoplakia. Following EMR, the patient did not receive further treatment for malakoplakia because she had no symptoms associated with malakoplakia. She has been well for more than 9 months, with no symptoms of disease. Awareness of colorectal malakoplakia is important in patients taking steroids, including oral contraceptives. 相似文献
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Summary In 5 closely controlled pregnant diabetics (duration of pregnancy 237–266 days) and 5 pregnant non-diabetics (duration of pregnancy 210–278 days) 4-hourly blood samples were taken throughout a 24 h period and analyzed for blood glucose, lactate, pyruvate, 3-hydroxybutyrate and acetoacetate, plasma non-esterified fatty acids (NEFA), glucagon and cortisol. 24 h urine specimen was analyzed for total catecholamines and 4-hydroxy-3-methoxymandelic acid. There were few significant differences in concentrations of metabolites and hormones in the two groups at any time, although the variations about the mean was usually greater in the diabetics. Thus for blood glucose in diabetics, mean value was 4.4 mmol/l, coefficient of variation 43%; in non-diabetics 4.1 mmol/l and 10% respectively. Mean plasma 3-hydroxybutyrate in diabetics was 0.47 mmol/l, coefficient of variation 55%; in non-diabetics 0.44 mmol/l and 37% respectively. Plasma non-esterified fatty acid levels were significantly higher in the diabetics (0.47 mmol/l) than in the non-diabetics (0.26 mmol/l). Coefficients of variation were 46% and 33% respectively. Two conclusions can be drawn; first, when near normal mean values for blood glucose are achieved, other metabolite and hormone levels are also near normal; second, even when the available means for diabetic control, strict diet and insulin-mixtures twice daily, are used at their maximum, metabolism in diabetics is more unstable than in non-diabetics. 相似文献
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Dr. N. M. Gupta M.S. A. Chaudhary M.S. V. Nanda M.D. A. K. Malik M.D. J. D. Wig M.S. F.R.C.S. 《Diseases of the colon and rectum》1985,28(6):451-453
Erosion of a retained surgical sponge into the intestine is an unusual occurrence and may make its appearance months or years
later. The demonstration of a distended bowel by the barium-impregnated mass with multiple polypoidal filling defects in a
patient who has undergone previous laparotomy should lead the physician to suspect a retained surgical sponge. Surgical intervention
is rewarding. 相似文献
70.
Tuning the endothelial response: differential release of exocytic cargos from Weibel‐Palade bodies 下载免费PDF全文
T. D. Nightingale J. J. McCormack W. Grimes C. Robinson M. Lopes da Silva I. J. White A. Vaughan L. P. Cramer D. F. Cutler 《Journal of thrombosis and haemostasis》2018,16(9):1873-1886
Essentials
- Endothelial activation initiates multiple processes, including hemostasis and inflammation.
- The molecules that contribute to these processes are co‐stored in secretory granules.
- How can the cells control release of granule content to allow differentiated responses?
- Selected agonists recruit an exocytosis‐linked actin ring to boost release of a subset of cargo.