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131.
Horseradish peroxidase injections were made at sites, within the midcollicular portion of the midbrain periaqueductal grey region (PAG), at which both electrical stimulation and subsequent microinjections of excitatory amino acids elicited defensive behaviour. Since excitatory amino acids depolarize cell bodies and dendrites located in the vicinity of the injection site but not axons of passage, the injections were centred within a PAG region known to contain neurones whose excitation elicited defensive behaviour. The telencephalic afferents to these sites were then determined. Sixty percent of the labelled telencephalic neurones were found in the frontal cortex, specifically in the medial frontal cortex along the banks of the rostral two-thirds of the cruciate sulcus, primarily area 6 and area 4, and the medial frontal cortex ventral to area 6 (area 32). Twenty-five percent of the labelled telencephalic neurones were found in the orbito-insular cortex while 8% were found in the parietal cortex surrounding the anterior ectosylvian sulcus. Although the functional significance of these projections remains to be established, available data suggest that these projections to the PAG arise from frontal 'oculomotor' and motor cortices, a polysensory insular cortical region and somatosensory, visual and auditory parietal cortical areas. 相似文献
132.
Ito S 《The Journal of comparative neurology》2002,444(1):10-24
Recent noninvasive human studies have reconfirmed the presence of a viscerally responsive region in the most lateral part of the primary somatosensory cortex (S1). The present electrophysiological study identified the corresponding area in rats as a vagal afferent projection region and examined the cytoarchitecture. Electrical stimulation of the cervical vagus nerve elicited a field potential comparable in waveform, latency, and amplitude to the simultaneously evoked potential in the insular visceral sensory cortex. The potential field adjoined the S1 trigeminal region without overlap, and was rostroventral to the lip representation barrel field, which was identified histochemically, and rostrodorsal to the tongue representation region, which was identified electrophysiologically. The vagal potential underwent a phase reversal in the middle layers; thus, the current sink site was cytoarchitectonically identified as the most rostral part of the parietal granular cortex or the S1, where no somatosensory input has previously been demonstrated. The rat S1 contains a region representing general visceral information, topographically located as if the visceral organs protruded from the mouth. 相似文献
133.
ul Quraish A Yang J Murakami K Oda S Takayanagi M Kimura A Kakuta S Kishi K 《Brain research》2004,1026(1):84-94
To understand the functional organization of the piriform cortex (PC), the axon collaterals of three pyramidal cells in layer IIb of the anterior PC and one pyramidal cell in layer IIb of the posterior PC were labeled and quantitatively analyzed by intracellular biocytin injection in the guinea pig. Single pyramidal cells in the anterior and posterior PCs have widely distributed axon collaterals, which exhibit little tendency for patchy concentrations inside as well as outside the PC. The total lengths of the axon collaterals of the three fully analyzed pyramidal cells ranged from 68 to 156 mm, more than 50% of which were distributed in the PC. The total number of boutons of the three cells ranged from 6000 to 14,000, 5000-7000 of which were distributed in the PC. It was estimated that individual pyramidal cells in layer IIb form synaptic contacts with 2200 to 3000 other pyramidal cells in the PC, indicating that single pyramidal cells in layer IIb receive input from a large number of other pyramidal cells. This high connectivity of the network of pyramidal cells in the PC can be regarded as the neural network operating parallel distributed processing, which may play an important role in experience-induced enhancement in odorant discrimination in the PC. 相似文献
134.
目的 了解海岛交警健康状况及影响因素。方法 采用整群随机抽样方法 ,通过现场调查结合实验室辅助检测手段 ,收集海岛交警健康监护及其相关资料 ,进行回顾性队列研究 ,结果用非条件Logistic回归分析。 结果 (1)外勤交警的眼、鼻、咽喉等系统的疾病与心电图异常的检出率明显高于内勤人员 (P <0 0 5 )。 (2 )外勤交警的血红蛋白含量、红细胞数、血小板计数等均高于内勤人员 (P <0 0 5 )。 (3)海岛交警的肾结石检出率较高 ,单因素分析提示可能与水产品的摄入量、身高、性格特征有关 ,而经常摄入鲜奶与水果可能是保护性因素。结论 海岛交警的职业因素对其健康有一定的影响 ,但危害程度是否低于非海岛地区还有待于进一步观察。 相似文献
135.
Blockade of cortical muscarinic but not NMDA receptors prevents a novel taste from becoming familiar
Exposure to a novel taste solution in the rat is followed by a decrease in its intake known as neophobia. This effect gradually disappears, and consumption increases from the second presentation of the taste (attenuation of neophobia), reflecting that the animal learned that it is safe to drink it. Conversely, if gastric malaise is induced after first intake, the rat will develop a long-lasting aversion (conditioned taste aversion). Previous attempts to elucidate the physiological nature of taste memory trace stems only from procedures that require malaise to measure taste memory. Here we assess the relevance of both muscarinic and N-methyl-d-aspartate receptors, known to be involved in conditioned taste aversion, on taste memory using a nonaversive procedure (attenuation of neophobia learning). Attenuation of neophobia was impaired by the muscarinic receptor antagonist, scopolamine, microinjected 20 min before, immediately after or up to 2 h after the first taste experience, suggesting that muscarinic receptors are involved in the acquisition and consolidation of attenuation of neophobia learning. However, the N-methyl-d-aspartate receptor antagonist, d,l-2-amino-5-phosphonovaleric acid, did not affect attenuation of neophobia even when the same dose of the drug was able to disrupt conditioned taste aversion learning, which suggests that attenuation of neophobia learning would be independent of N-methyl-d-aspartate receptors activity in the insular cortex. The neophobic response induced by strong saccharin presentation was not affected by either of the treatments given, which rules out any impairment in taste perception. These results indicate that while cortical muscarinic receptors are important in the formation and consolidation of safe memory trace, N-methyl-d-aspartate receptor activity appears to be noncritical. 相似文献
136.
Kindling is a model in which an initially subconvulsive electrical stimulation of certain brain areas eventually develops a generalized seizure that produces behavioral and long term neuronal changes. In the present study we evaluated if kindling can modify conditioning taste aversion (CTA). In this paradigm animals acquire aversion to saccharin when it is presented as the conditioned stimulus (CS) followed by an injection of lithium chloride (LiCl) that induces a gastric irritation as the unconditioned stimulus (US). Male Wistar rats were implanted with bipolar electrodes aimed at the right amygdala (AMG) or at the right insular cortex (IC). The animals were stimulated daily until they reached stages 2-4 (intermediate) or until kindling was fully established (three consecutive stage 5 seizures). At least two weeks after kindling stimulation had ceased the animals were deprived of water for 24 h and given 10-min drinking sessions twice a day for 4 days. On day 5 (morning session) tap water was replaced by saccharin solution (0.1%), 20 min later the animals were injected with LiCl (7.5 ml/kg i.p., 0.2 M) to induce gastric malaise or taste aversion. After three more days of baseline consumption, water was substituted by a fresh 0.1% saccharin solution to test the aversion. AMG-kindling delayed the extinction of CTA. Animals with kindling in the IC had a higher retention than the sham kindling group; that is, they drank significantly less saccharin solution than the other groups. The results of the present experiment show that local modification of brain function induced by kindling stimulation can prolong the aversive effects of CTA. 相似文献
137.
目的 探讨外侧裂-岛叶入路和额中回皮质入路对高血压基底节脑出血(hypertensive basal ganglia hemorrhage, HBGH)患者的血肿清除效果。方法 选取2019-10至2022-01在北京昌平医院手术的108例HBGH患者,按手术方案不同分为两组,每组54例。对照组采用侧裂-岛叶入路血肿清除术,观察组采用额中回入路血肿清除术,对两组患者的手术时间、苏醒时间、血肿清除率及术后3个月格拉斯哥预后评分(Glasgow outcome scale, GOS)进行对比分析。结果 观察组血肿清除率为91.63%±0.77%,高于对照组(82.82%±2.62%),差异有统计学意义(P<0.05),且手术时间、术中出血量、手术后并发症发生率、住院时间均显著优于对照组,差异有统计学意义(P<0.05);观察组患者术后3个月的GOS评分显著高于对照组,差异有统计学意义(P<0.05)。结论 HBGH患者采用经额中回入路清除血肿,血肿清除率高,可缩短手术时间,改善患者神经功能预后。 相似文献
138.
The insular cortex (IC) processes gustatory and visceral information, which functionally correlate to feeding behavior. Insulin, a well-known hormone controlling glucose metabolism, is released by elevation of blood glucose concentration following feeding behavior. The IC expresses dense insulin receptors and receives projection from the hypothalamus, which monitors changes in glucose concentration. Therefore, it is likely that insulin modulates neural properties in the IC. However, little is known about the effects of insulin on electrophysiological properties of the neocortex including the IC. To explore the effects of insulin on subthreshold responses and action potential properties in the IC, intracellular recording with sharp glass electrodes was performed from IC pyramidal cells using slice preparations. Although application of insulin (100 nM) had little effect on the resting membrane potential, input resistance and rheobase, insulin significantly increased the frequency of repetitive spike firing in response to a long depolarizing current pulse injection: the slope of the frequency-current curve was increased from 23.7±2.3 Hz/nA to 29.5±3.4 Hz/nA. Insulin slightly decreased the action potential threshold without affecting the amplitude of medium-duration and slow afterhyperpolarization (sAHP) s. The insulin-induced facilitation of repetitive spike firing was dose-dependent and blocked by pre-application of 200 nM lavendustin A, a tyrosine kinase inhibitor. Moreover, when combined with 200 nM wortmannin, a phosphoinositide 3-kinase (PI3-K) inhibitor, or 500 nM deguelin, an inhibitor of protein kinase B (PKB/Akt) downstream of PI3-K, insulin failed to increase the frequency of repetitive spike firing. In contrast, co-application of insulin and (10 μM) PD 98059, an inhibitor of mitogen activated protein kinase (MAPK), exerted facilitation of repetitive spike firing. These results suggest that acute insulin-induced facilitation of firing frequency is at least partially induced by hyperpolarizing effects on the action potential threshold, and that this facilitation is induced by activation of PI3-K but not MAPK cascade. 相似文献
139.
Hannah Bruguier Rodrigo Suarez Paul Manger Anna Hoerder-Suabedissen Andrew M. Shelton David K. Oliver Adam M. Packer José L. Ferran Fernando García-Moreno Luis Puelles Zoltán Molnár 《The Journal of comparative neurology》2020,528(17):2956-2977
The human claustrum, a major hub of widespread neocortical connections, is a thin, bilateral sheet of gray matter located between the insular cortex and the striatum. The subplate is a largely transient cortical structure that contains some of the earliest generated neurons of the cerebral cortex and has important developmental functions to establish intra- and extracortical connections. In human and macaque some subplate cells undergo regulated cell death, but some remain as interstitial white matter cells. In mouse and rat brains a compact layer is formed, Layer 6b, and it remains underneath the cortex, adjacent to the white matter. Whether Layer 6b in rodents is homologous to primate subplate or interstitial white matter cells is still debated. Gene expression patterns, such as those of Nurr1/Nr4a2, have suggested that the rodent subplate and the persistent subplate cells in Layer 6b and the claustrum might have similar origins. Moreover, the birthdates of the claustrum and Layer 6b are similarly precocious in mice. These observations prompted our speculations on the common developmental and evolutionary origin of the claustrum and the subplate. Here we systematically compare the currently available data on cytoarchitecture, evolutionary origin, gene expression, cell types, birthdates, neurogenesis, lineage and migration, circuit connectivity, and cell death of the neurons that contribute to the claustrum and subplate. Based on their similarities and differences we propose a partially common early evolutionary origin of the cells that become claustrum and subplate, a likely scenario that is shared in these cell populations across all amniotes. 相似文献
140.
fMRI identifies the right inferior frontal cortex as the brain region where time interval processing is altered by negative emotional arousal
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Micha Pfeuty Bixente Dilharreguy Loïc Gerlier Michèle Allard 《Human brain mapping》2015,36(3):981-995
The reason why human beings are inclined to overestimate the duration of highly arousing negative events remains enigmatic. The issue about what neurocognitive mechanisms and neural structures support the connection between time perception and emotion was addressed here by an event‐related neuroimaging study involving a localizer task, followed by the main experiment. The localizer task, in which participants had to categorize either the duration or the average color of visual stimuli aimed at identifying the neural structures constitutive of a duration‐specific network. The aim of the main experiment, in which participants had to categorize the presentation time of either neutral or emotionally negative visual stimuli, was to unmask which parts of the previously identified duration‐specific network are sensitive to emotionally negative arousal. The duration‐specific network that we uncovered from the localizer task comprised the cerebellum bilaterally as well as the orbitofrontal, the anterior cingulate, the anterior insular, and the inferior frontal cortices in the right hemisphere. Strikingly, the imaging data from the main experiment underscored that the right inferior frontal cortex (IFC) was the only region within the duration‐specific network whose activity was increased in the face of emotionally negative pictures compared to neutral ones. Remarkably too, the extent of neural activation induced by emotionally negative pictures (compared to neutral ones) in this region correlated with a behavioral index reflecting the extent to which emotionally negative pictures were overestimated compared to neutral ones. The results are discussed in relation to recent models and studies suggesting that the right anterior insular cortex/IFC is of central importance in time perception. Hum Brain Mapp 36:981–995, 2015. © 2014 Wiley Periodicals, Inc. 相似文献