全文获取类型
收费全文 | 14919篇 |
免费 | 1124篇 |
国内免费 | 115篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 1005篇 |
妇产科学 | 53篇 |
基础医学 | 2380篇 |
口腔科学 | 195篇 |
临床医学 | 509篇 |
内科学 | 1262篇 |
皮肤病学 | 140篇 |
神经病学 | 677篇 |
特种医学 | 90篇 |
外科学 | 303篇 |
综合类 | 658篇 |
一般理论 | 1篇 |
预防医学 | 6861篇 |
眼科学 | 16篇 |
药学 | 1493篇 |
4篇 | |
中国医学 | 273篇 |
肿瘤学 | 230篇 |
出版年
2023年 | 233篇 |
2022年 | 977篇 |
2021年 | 1214篇 |
2020年 | 633篇 |
2019年 | 600篇 |
2018年 | 555篇 |
2017年 | 503篇 |
2016年 | 494篇 |
2015年 | 609篇 |
2014年 | 792篇 |
2013年 | 1275篇 |
2012年 | 642篇 |
2011年 | 798篇 |
2010年 | 558篇 |
2009年 | 550篇 |
2008年 | 580篇 |
2007年 | 550篇 |
2006年 | 422篇 |
2005年 | 387篇 |
2004年 | 369篇 |
2003年 | 319篇 |
2002年 | 265篇 |
2001年 | 224篇 |
2000年 | 185篇 |
1999年 | 163篇 |
1998年 | 165篇 |
1997年 | 139篇 |
1996年 | 130篇 |
1995年 | 132篇 |
1994年 | 110篇 |
1993年 | 83篇 |
1992年 | 116篇 |
1991年 | 90篇 |
1990年 | 90篇 |
1989年 | 75篇 |
1988年 | 94篇 |
1987年 | 62篇 |
1986年 | 52篇 |
1985年 | 112篇 |
1984年 | 110篇 |
1983年 | 86篇 |
1982年 | 95篇 |
1981年 | 69篇 |
1980年 | 82篇 |
1979年 | 72篇 |
1978年 | 62篇 |
1977年 | 44篇 |
1976年 | 52篇 |
1975年 | 41篇 |
1974年 | 28篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
61.
Jamie Dollahite Wene George M. Barnwell Daniel S. Mitchell 《Physiology & behavior》1982,28(3):569-573
To evaluate the influence of flavor on ad lib consumption and on associated changes in body weight, female baboons, 7–15 years of age, served in two experiments with seven monkey chows which were identical except for flavor: lemon, orange, apple, sugar, fruit punch, chocolate, and unflavored. In the first experiment, two groups of animals (n=7 and 4) received five of the seven flavors, presented in daily pair-wise combinations. Analysis of quantities consumed demonstrated marked and consistent flavor preferences in individual baboons. Although specific preference varied between animals, total amounts consumed of the various flavors differed significantly, with rank ordering clearly evident. Overall food intake and body weights increased significantly over baseline values obtained with a standard, unflavored chow. In the second experiment, three baboons received chow of a preferred flavor for nine weeks. Amounts consumed and body weights increased significantly over baseline. These results indicate that flavored chows may be useful for producing a nonhuman primate behavioral model of obesity and for inducing animals to eat otherwise unpalatable diets. 相似文献
62.
Fat in the intestine as a regulator of appetite--role of CCK 总被引:1,自引:0,他引:1
The present review summarizes the appetite-suppressing effects of intestinal fat in the regulation of food intake in humans, with a special focus on the role of cholecystokinin (CCK). Current evidence supports a role for intestinal fat (especially long-chain free fatty acids) acting via the peptide CCK as a physiological satiety pathway. The regulation of satiety is, however, complex and it is not surprising that multiple control systems exist. It is interesting to note that nutrients, such as hydrolysis products of fat in the small intestine, stimulate the release of satiety peptides, such as CCK or PYY, that serve as satiety signals. CCK, released from the gastrointestinal tract by the local action of digested food, exerts various functions: stimulation of gallbladder contraction and exocrine pancreatic secretion, inhibition of gastric emptying, and inhibition of appetite. CCK functions therefore (1) as a positive feedback signal to stimulate digestive processes and (2) as negative feedback signal to limit the amount of food consumed during an individual meal. 相似文献
63.
Thirty-two children and two adults with chronic atopic dermatitis related to food allergy entered this double-blind crossover study comparing oral sodium cromoglycate (200–1600 mg/24 h) with placebo. Each treatment period comprised 6 weeks: 1 weeks on elimination diet, and 2 weeks on a normal. i.e. unrestricted diet. The diagnosis of food allergy was made after clinical improvement with elimination diet and relapse after challenge. Overall analysis of skin symptoms evaluated by means of clinical assessments and diary cards, opinions of treatment, and use of concomitant medication gave no evidence of any difference between sodium cromoglycate and placebo. Unusual symptoms were reported by 18 patients. In one case the patient was withdrawn during the sodium cromoglycate period because of side effects. The majority of symptoms with both treatments were stomach problems. Overall analysis of the laboratory data gave no significant differences between treatments. 相似文献
64.
S. A. Kurilovich E. V. Pozdeeva A. P. Serdyuk I. O. Svetlova Yu. A. Shakhov 《Bulletin of experimental biology and medicine》1990,110(6):1660-1663
Institute of Therapy, Siberian Branch, Academy of Medical Sciences of the USSR, Novosibirsk. All-Union Preventive Medicine Research Center, Ministry of Health of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR Yu. P. Nikitin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 110, No. 12, pp. 611–613, December, 1990. 相似文献
65.
Control of protein intake was studied in young rats that were allowed to choose between either protein-free and 55% casein diets or 15% and 55% casein diets. Animals on the protein-free vs. 55% casein regimen exhibited a lower weight gain, a lower cumulative energy intake and a greater cumulative total protein intake during the 13-day study compared to rats selecting between 15% and 55% casein. The daily average proportion of total food selected as casein by animals choosing between protein-free and 55% casein diets increased from 15% to 38% during the course of the study. In contrast, rats choosing between 15% and 55% casein chose 18-22% of total food as protein throughout the entire study. Long-term protein intake or protein selection did not correlate significantly with whole-brain contents of 5-HT or 5-HIAA. Our results suggest that protein intake is not regulated at a constant proportion of total calories, but is controlled between a minimum level that will support rapid growth and a maximum that, if exceeded, would require the animal to undergo substantial metabolic adaptation. The mechanism controlling protein selection may involve diet-induced changes in the brain content of total free indispensable amino acids. 相似文献
66.
We examined the factors influencing maternal food intake and pup growth in Norway rats. Mother rats allowed pups in naturally large litters to grow at a slower rate than pups in naturally small litters. Pups reared by dams in a warm ambience (26°C) gained weight more slowly than dams at 22°C, and maternal food intake but not weight gain was depressed in the high ambient temperature. Pup growth at 18°C was unimpaired, with those dams eating no more and gaining no less weight than dams at 22°C. Nest material, however, was found to be essential for the successful rearing of young at cooler ambient temperatures. While restriction of food during gestation resulted in a marginally lower weight gain for the pups during the first 2 weeks postpartum, the dams appeared not to mobilize corporal stores or increase their food intake during lactation. Heavy body weight mothers did not eat any more, nor did they gain any less weight nor rear larger pups than light body weight dams. Rat mothers increased their consumption of a diet diluted with non-nutritive fiber to equal the nutritive intake of their controls, with their pups not differing in their growth rate. Pups reared by dams eating a high quality diet grew faster than pups with dams on the control diet. Food intake by mother rats is required during lactation relative to the amount of milk that is delivered to the pups, rather than to an absolute amount of food. Lactating females with a concurrent pregnancy neither increase their food intake nor appear to mobilize their corporal stores to deal with the added energetic drain of pregnancy. Indeed, their young grew somewhat more quickly than pups nursed by dams that were simply lactating. Taken as a whole, these results suggest that Norway rat dams apparently do not monitor and defend a maximal pup growth rate. Rather, rat dams seem to continue to defend their own homeostasis, and by doing so, allow the young to grow and survive under a wide variety of circumstances. 相似文献
67.
Nutritional studies on rats given a choice between two diets differing in protein content have led to the proposal that brain 5-HT content regulates protein intake [2]. Pharmacologic studies under similar conditions of dietary self-selection suggest that brain 5-HT controls carbohydrate intake [41]. We tested the effect of elevating brain 5-HT via tryptophan injection (100 mg/kg) on short-term food intake and selection by rats choosing between two diets differing in protein and carbohydrate content. Under these conditions neither total food intake nor protein and carbohydrate selection were affected despite increases of 50% in brain concentrations of 5-HT and 5-HIAA. The effect of Trp administration was selective to serotonin metabolism as brain concentrations of NE, DA and DOPAC were not affected. These results suggest that alterations in brain 5-HT content which may occur following meal ingestion may not be of physiological importance in regulating nutrient intake and selection. 相似文献
68.
Central amygdaloid nucleus lesions in rats had no effect on recovery of preoperative body weight and food consumption levels. The brain damaged rats also recovered preoperative levels of water consumption as rapidly as control rats but then developed a mild but persistent hypodipsia. The experimental rats also drank less than control rats when food deprived and showed marginally reliable decreases in 0.1% quinine solution consumption and latency to consume a novel food. There was no detectable lesion effect on 0.1% saccharin solution consumption, exploration of a novel environment or formation of a learned taste aversion. It is suggested that the central amygdaloid nucleus has a role in mediating the relationship between food and water intake and in some taste mediated consummatory behavior. 相似文献
69.
Donald A. Czech 《Physiology & behavior》1982,29(6):1179-1181
An casuy constructed and inexpensive drop-sensing drinkometer is described, which incorporates an integrated circuit photodetector. It provides a reliable and convenient means of automatically monitoring fluid intake in a number of experimental situations. The animal is undisturbed and isolated from the electrical system components. 相似文献
70.
Body weight and food intake of lean and obese, male and female Osborne-Mendel rats following treadmill exercise were compared. Rats were assigned, separately by sex, to one of three diet groups; Group 1 was fed a low fat (10%) diet throughout the study, Group 2 was fed a high fat (55%) diet for 16 weeks and then switched to the low fat diet 1 week prior to exercise, and Group 3 was fed the high fat diet throughout the study. To control for differences in work output between the leanest and heaviest animals, exercise intensity was adjusted across groups such that all exercised rats had equivalent energy expenditure. After a 3 day training period, the exercise was successively increased over 8 days until a work output of 374.9J was reached. Relative to their respective controls, obese exercised males showed a reduction in body weight but no change in food intake. In contrast, exercised females showed no change in body weight or food intake, regardless of dietary condition. 相似文献