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991.
L. T. Ostasiewicz J.-L. Huang X. Wang S. Piomelli M. B. Poh-Fitzpatrick 《Photodermatology, photoimmunology & photomedicine》1995,11(1):18-21
Inherited deficiency of ferrochelatase results in erythropoietic protoporphyria (EPP). Genetic heterogeneity at the locus for human ferrochelatase was investigated. Analysis of genomic DNA of patients with EPP and of control subjects by restriction endonuclease techniques using ten different enzymes detected polymorphisms only at sites recognized by EcoRI, HincII, PstI and TaqI. None of these polymorphisms alone was specific for expression of the disease since each was observed in control subjects as well. Three of these polymorphisms (at EcoRI, HinII and PstI sites) were always associated, indicating linkage. These and other studies demonstrate that the ferrochelatase gene is markedly heterogeneous. It is not yet clear whether some of the mutations associated with these polymorphisms contribute to expression of EPP. 相似文献
992.
微螺钉型种植体支抗长度及直径对应力分布影响的三维有限元研究 总被引:12,自引:0,他引:12
目的探索微螺钉型种植体支抗的长度及直径对种植体周围骨组织内应力分布的影响。方法建立简单的上颌骨及不同长度直径的微螺钉型种植体的三维有限元模型,模拟临床实际情况,记录不同尺寸的种植体在相同的加载条件下周围骨组织内应力分布的情况,并进行比较。结果随着种植体直径的增加,骨组织内的应力明显降低;种植体长度的增加对降低应力没有明显作用。结论在所研究的尺寸范围内,种植体的直径对应力分布有重要影响,而种植体的长度对应力分布影响不大。 相似文献
993.
目的 探讨房室结正、逆向文氏周期与心房颤动(atrial fibrillation,AF)的关系。方法 回顾性分析房室结双径路电生理检查时诱发心房颤动及未诱发出心房颤动病例正、逆向文氏周期特点。结果 18例电生理检查诱发出心房颤动的病例,其逆向文氏点时间与正向文氏点时间之差明显大于未诱发出心房颤动的病例。结论 房室结正、逆相文氏点之差较大时易诱发出心房颤动。 相似文献
994.
Abstract – The aim of this study was to establish if a predesigned prompt in the form of a reminder stamp placed in a patient's dental records is more effective for recording the essential details of a diagnostic working length compared to the current practice without any specific prompts. Following a pilot study of current practice, a stamp was introduced. Twelve months following the introduction of the stamp, 198 patient records were examined, where endodontic treatment had been carried out mainly for traumatic injuries. The following parameters were specifically investigated whether a radiograph had been taken to establish working length and was it available for examination, whether the working length was recorded in the notes and whether a reference point for the measurements was given. The working length was conventionally recorded by 127 notes, whereas 71 used the stamp. A working length radiograph was taken and a working length recorded for 95% of the cases where no stamp had been used, compared to 100% of the stamp group. Where no stamp had been used only 83% of working length radiographs were available compared to 100% of the stamp group. Interestingly, a reference point from where the working length had been measured was only recorded in 5% of the cases where the stamp had not been used compared to 94% using the predesigned stamp. This result was statistically significant using a chi-squared test ( P < 0.001). The stamp was generally more effective than the conventional method of recording the working length for endodontics. 相似文献
995.
细胞间黏附分子-1基因多态性与老年无症状性脑白质损害的相关性 总被引:2,自引:0,他引:2
目的 探讨健康老年人无症状性脑白质损害(WML)和细胞间黏附分子1 (ICAM -1)K469E基因多态性之间的关系。方法 利用聚合酶链式反应限制性片段长度多态性法(PCR RFLP),对121例WML患者和99名对照组老年人的ICAM 1K469E基因多态性位点进行检测和分析。结果 病例组和对照组ICAM 1K469E多态性分布符合Hardy Weinberg遗传平衡定律,说明研究对象具有群体代表性。WML组KK基因型和K等位基因频率均明显高于对照组(基因型50. 4%vs25. 3%,P<0. 01;等位基因频率73 .1% vs52. 0%,P=0 .002),两组间差异有统计学意义。Logistic多因素回归分析显示在校正高血压、年龄等因素后,ICAM 1KK型与WML的发生相关(OR=2 99,P=0. 01)。和非KK型个体相比,KK型个体患WML相对危险度是前者的2. 99倍。结论 ICAM 1KK基因型与WML的发生具有相关性,提示ICAM 1基因K469E多态性可能是中国人WML发病的遗传学危险因素。 相似文献
996.
997.
The British Association of Otolaryngologists has laid down guidelines on the length of time that should be allocated to an out‐patient consultation. The General Medical Council (GMC) has also produced guidelines as to what is to be discussed with a patient during an out‐patient consultation. This study was designed to determine what effect adhering to the GMC's guidelines would have on the length of an out‐patient consultation. Out‐Patient consultations were timed for patients referred with common otolaryngological complaints. The study was then repeated after the researchers had been given specific instructions on what to discuss with the patients to comply with the GMC guidelines. Consultation times more than doubled after application of the GMC guidelines. This study highlights the difficulty of specifically adhering to guidelines from our regulatory body, while attempting to fulfil the demands for consultations, with the existing manpower levels available. 相似文献
998.
999.
S. P. Singh Subas Rai A. K. Rai S. P. Tiwari S. S. Singh Samarketu J. Abraham 《Medical & biological engineering & computing》1994,32(2):175-180
Athermal physiological effects of continuous wave and modulated microwaves were studied on a cynobacterium Nostoc muscorum.
The study shows that different microwave frequencies in continuous wave and modulated modes produced significantly different
physiological effects on the algae. Water-mediated bioeffects further present additional proof that water has the capability
to remember the imposed electromagnetic field characteristics for an extended period of time. 相似文献
1000.
应用PCR/RFLP方法对广东籍22名正常人及20名胰岛素依赖型糖尿病人(IDDM)进行了HLA-DQB1等位基因分型。结果:在DQB1等位基因中未发现单独出现于IDDM的类型;全部等位基因中正常对照组与IDDM组间均无显著性差异;非Asp-57编码的DQB1等位基因与广东籍IDDM病人不相关;广东籍IDDM的免疫遗传基因可能在HLA-DQB1以外的其它位点。 相似文献