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32.
In vitro characterization of peptide-modified p(AAm-co-EG/AAc) IPN-coated titanium implants. 总被引:1,自引:0,他引:1
Thomas A Barber Lara J Gamble David G Castner Kevin E Healy 《Journal of orthopaedic research》2006,24(7):1366-1376
Interpenetrating polymer networks (IPNs) of poly(acrylamide-co-ethylene glycol/acrylic acid) [p(AAm-co-EG/AAc)] functionalized with an -Arg-Gly-Asp- containing peptide derived from rat bone sialoprotein [bsp-RGD(15)] were grafted to titanium implants in an effort to modulate osteoblast behavior in vitro. Surface characterization data were consistent with the presence of an IPN, and ligand density measurements established that the range of peptide density on the modified implants spanned three orders of magnitude (0.01-20 pmol/cm2). In vitro biological characterization of the modified implants employing the primary rat calvarial osteoblast (RCO) model resulted in the identification of a critical ligand density (0.01相似文献
33.
一种新型人TNFα对人肝癌裸鼠移植瘤的抗瘤作用 总被引:1,自引:1,他引:0
用人肝癌Bel7402瘤株建立了人肝癌裸鼠移植瘤模型,探讨新型重组人TNFa对这种移植瘤的抗瘤作用,结果表明,rhTFaD11a和原型重组人TNFa的抑瘤率在30%左右时,后者后用的活性产闰数是前者的2倍;两者用量相同时,前者的抑产经比后者提高23个百分 相似文献
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Pharmaceutical Research - 相似文献
36.
The distribution of GABA-producing neurons in the brainstem auditory nuclei of the rat was investigated immunohistochemically by using an antibody to glutamic acid decarboxylase (GAD). In the cochlear nuclei, GAD immunoreactive neurons are present only in the superficial granular and molecular layers, whereas terminals are found in all subdivisions of the nuclei and are particularly dense surrounding large spherical cells and one type of stellate cell. In the superior olivary complex, GAD immunoreactive neurons are located in the lateral olivary nucleus and throughout the periolivary region. Immunoreactive terminals are distributed along dendrites of principal cells of the medial and lateral olivary nuclei and are clustered around somata of globular neurons of the nucleus of the trapezoid body. An extremely dense band of immunoreactive somata and terminals is present along the ventral edge of the olivary complex. The ventral, intermediate, and dorsal nuclei of the lateral lemniscus contain small fusiform GAD-immunoreactive neurons and a moderately dense plexus of immunoreactive terminals. The inferior colliculus contains a large population of GAD-immunoreactive perikarya and an extremely dense accumulation of immunoreactive terminals in the central, dorsomedial, and external nuclei. These observations indicate that GABA systems are involved in function at all levels of the brainstem auditory pathway. 相似文献
37.
Summary The Bichat's fat pad (Corpus adiposum buccae) is of great significance in facial contouring. Resection of major parts of this fat pad results in hollow cheeks and in accentuation of the zygoma. On the other hand, hypoplasia or shrinkage of this fat pad can be augmented by means of silicone implants for improved aesthetic results. 相似文献
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A morphometric analysis of the developing organ of Corti and its component hair cells was carried out in an age-graded series of Syrian golden hamsters with the aid of scanning electron microscopy. The purpose was to establish a quantitative framework that would provide insight into the rules and principles by which the mammalian cochlea attains its adult proportions. This study examined postnatal development at two day intervals from birth to 22 days after birth. Our analysis included measures of cochlear length and hair cell numbers as well as measures of hair cell sizes in each of five sectors along the cochlear spiral. Our results demonstrate several principles of cochlear development: (1) The full two and one-fourths turns seen in the adult cochlea are already present at birth, but the cochlea continues to elongate for the next 10–12 days. (2) Development of hair cells in the apex generally lags behind that in the base. Whereas the stereocilia and apical margins of hair cells are clearly defined in the basal turn, they become well defined in the apex only postnatally. (3) Growth in cochlear length occurs mainly by increases in cell size rather than in cell numbers; although hair cells do increase in numbers during the first 4 days of cochlear growth, this increase involves addition of hair cells only to preexisting regions of the cochlear apex. Moreover, the full complement of hair cells is established 6 days before the full size of the cochlea is attained; in contrast, hair cell growth occurs at all positions along the cochlear spiral and spans the entire period of cochlear elongation. (4) The period of hair cell growth exceeds the period of organ of Corti growth and appears to be possible by decreases in intercellular spacing, primarily in the apical region of the cochlea; inner and outer hair cell growth was complete between 16 and 18 days after birth. (5) Inner and outer hair cell neighbors remain virtually constant at different ages indicating that the spatial relationships between the two hair cell populations is preserved as the cochlea grows. (6) Comparison with previous developmental studies of auditory function in the hamster reveals that the age of 16 days after birth, when hair cells attain their mature sizes, coincides with the onset of brainstem auditory evoked responses. Growth of hair cell somas alone, however, cannot explain either the subsequent maturation of evoked potential thresholds or changes in frequency representation in the developing cochlea. © Wiley-Liss, Inc. 相似文献
39.
目的探讨Medpor义眼座植入同期放置钛钉治疗眼球摘除术后眼眶凹陷畸形的有效性和可行性。方法眼球摘除同期置入Medpor义眼座患者80例,随机分为钛钉Ⅰ期置入组和Ⅱ期置入组,每组各40例。比较两组患者术中、术后出现的并发症和患者对义眼活动度和外观的满意程度。结果40例Ⅰ期置入患者术中有37例在术后2~6周时钛钉尾端自发性暴露,只有3例患者需要剪开结膜使钛钉尾端暴露。术后出现并发症者共37例,占46%:其中Ⅰ期置入组17例,Ⅱ期置入组加例,两者差异无统计学意义(P=0.501)。所有患者对其外观和活动度满意,其中Ⅰ期置入组非常满意36例,比较满意4例;Ⅱ期置入组非常满意34例,比较满意6例,两者差异无统计学意义(P=0.502)。结论Medpor义眼座置入同期放置钛钉治疗眼球摘除术后眼眶凹陷畸形,是一种安全有效的手术方法,同时患者避免了再次手术的痛苦。 相似文献
40.
本研究对钛种植体-羟基磷灰石(Ti-HA)在早期修复下颌骨缺损中与骨结合的界面形态进行了扫描电镜和X线能谱观察分析。通过对9只健康狗下颌骨缺损区植入Ti-HA2、6及12周后Ti-HA/宿主骨界面及Ti/HA界面的扫描电镜观察和X线能谱分析,结果表明Ti-HA植入骨缺损区,不引起正常的骨矿化过程改变,与宿主骨形成骨性结合;Ti/HA界面有新骨形成;扫描电镜观察和X线能谱分析在研究骨缺损修复过程中不同阶段的组织成份的变化是一个重要手段。 相似文献