首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   5648篇
  免费   504篇
  国内免费   146篇
耳鼻咽喉   96篇
儿科学   227篇
妇产科学   225篇
基础医学   359篇
口腔科学   27篇
临床医学   516篇
内科学   1139篇
皮肤病学   29篇
神经病学   309篇
特种医学   222篇
外科学   490篇
综合类   454篇
预防医学   1018篇
眼科学   65篇
药学   402篇
  2篇
中国医学   24篇
肿瘤学   694篇
  2024年   5篇
  2023年   131篇
  2022年   272篇
  2021年   371篇
  2020年   275篇
  2019年   272篇
  2018年   315篇
  2017年   237篇
  2016年   199篇
  2015年   251篇
  2014年   488篇
  2013年   508篇
  2012年   350篇
  2011年   419篇
  2010年   273篇
  2009年   277篇
  2008年   285篇
  2007年   238篇
  2006年   223篇
  2005年   138篇
  2004年   120篇
  2003年   90篇
  2002年   68篇
  2001年   59篇
  2000年   51篇
  1999年   34篇
  1998年   35篇
  1997年   27篇
  1996年   29篇
  1995年   26篇
  1994年   29篇
  1993年   22篇
  1992年   19篇
  1991年   23篇
  1990年   15篇
  1989年   14篇
  1988年   20篇
  1987年   11篇
  1986年   8篇
  1985年   3篇
  1984年   11篇
  1983年   5篇
  1982年   7篇
  1981年   12篇
  1980年   3篇
  1979年   4篇
  1978年   5篇
  1977年   4篇
  1971年   5篇
  1970年   3篇
排序方式: 共有6298条查询结果,搜索用时 15 毫秒
91.
92.
Background/objectivesUniversal screening for elder abuse and neglect is a current controversy in geriatrics, fueled by the lack of evidence on valid and reliable instruments. Since each U.S. State and many other countries have their own legal definitions of what constitutes elder abuse and neglect, this further complicates instrument development and clinical assessment. The purpose of this paper is to present data on the sensitivity and specificity of the QualCare Scale, an instrument with utility in detecting clinically significant elder abuse and neglect among older adults receiving care at home.DesignData used in this analysis were collected during a training program in which trainees completed assessments (N = 80) of standardized case scenarios of caregiving dyads. Trainees completed the QualCare Scale during each assessment.SettingThis training program, including the assessments of the standardized case scenarios, was completed using a custom designed virtual-reality platform. Trainees were able to interact with the environment, older adult and caregiver within the case scenario.ParticipantsThirty-six nurses and social workers from two Michigan Medicaid Waiver Sites participated in the training program. Each participant assessed between one and five scenarios, yielding the sample of 80 assessments used in this analysis.MeasurementsThe research team designed each standardized case scenario to reflect whether or not the QualCare Scale subscale score should indicate reportable elder abuse and neglect per the State statute. Accordingly, the research team’s QualCare Scale scores for each scenario were used as the gold standard criterion of clinical significance for comparison against the participant’s assessment scores.ResultsSensitivity and specificity for each of the six QualCare subscales was determined. Overall, the subscales had high sensitivity (≥0.811) but a wide range for specificity (0.167–1.000).ConclusionThe QualCare Scale can be an effective tool in detecting clinically significant elder abuse and neglect among older adults receiving care at home. This tool is suitable and feasible for use by practitioners working in home care. The QualCare Scale score indicating clinically significant or reportable elder abuse and neglect can be raised or lowered to be consistent with State or Country statutes, or simply used to create appropriate care plans to support caregiving. Findings from the QualCare Scale can support the multidisciplinary team in planning for and evaluating preventative interventions.  相似文献   
93.
《中国现代医生》2021,59(19):75-77+81
目的 探讨基层医院实施围产期B族链球菌感染筛查及防治的价值。方法 回顾性分析我院2019年7月至2020年7月纳入的4220例围产期孕妇作为研究对象,收集并整理其齐全资料,并在我院接受阴道与直肠的B族链球菌感染筛查,经B族链球菌感染筛查结果,将其中507例阳性者作为阳性组,另3713例阴性者作为阴性组,分析围产期B族链球菌感染筛查及防治运用于基层医院中的价值。结果 本院所有研究对象均接受B族链球菌感染筛查,结果发现阳性者507例,阳性率为12.01%;阴性者3713例,阴性率为87.99%。两组在剖宫产、产后出血、产褥感染、新生儿窒息、胎儿窘迫上比较,差异无统计学意义(P0.05);但阳性组的绒毛膜羊膜炎、羊水污染、胎膜早破、新生儿感染发生率均高于阴性组(P0.05)。结论 基层医院中实施围产期B族链球菌感染筛查具有重要意义,应受到医疗界重点关注,经过筛查后尽早给予有效干预,从而避免不良妊娠结局产生,保障母婴安全。  相似文献   
94.
95.
目的 分析广州市开展现行大肠癌筛查策略的效果。方法 收集、整理2015-2016年广州市大肠癌筛查数据,评价问卷调查、便隐血检查和全结肠镜检查的筛查效果。结果 2015-2016年广州市50~74岁重点人群完成初筛220 834人,初筛阳性37 040例(16.77%)。全结肠镜检7 821人,肠镜检查顺应率为21.12%(7 821/37 040)。发现各类肠道病变4 126例(52.76%),其中进展性腺瘤614例(7.85%)、伴中/重度异型增生的其他病变73例(0.93%),大肠癌230例(2.94%);各类病变中男性检出率均高于女性(P<0.01)。病变早诊率为87.24%;筛查发现早期癌99例,占总大肠癌的46.26%。大肠癌筛查发现率为104.15/10万,明显高于相应年龄段(50~74岁)大肠癌监测发病率81.18/10万(P<0.001),表现为≤69岁年龄段大肠癌发现率明显高于相应发病率,≥70岁年龄段则相反。结论 广州市大肠癌筛查策略可以发现大肠癌高危人群,提高全结肠镜病变检出率、癌前病变早诊率和早期大肠癌的诊断比例,≤69岁人群受益高于70~74岁人群,是大肠癌筛查重点关注人群,应需进一步促进高危人群肠镜检查顺应性。  相似文献   
96.
There is accumulating evidence demonstrating that early treatment leads to better outcomes in rheumatoid arthritis. In order to be treated early, patients thus need to be identified at the earliest possible stage. This means identifying patients with rheumatoid arthritis at their earliest clinical signs but it could also mean screening for healthy individuals at high risk of developing rheumatoid arthritis. The different tools available to screen for these individuals are reviewed here and their relevance is discussed.  相似文献   
97.

Background

Recent trends have identified increasing number of young individuals with rectal and colon cancers. These individuals, who are younger than 50 years old, in most instances would not meet screening guidelines. We aimed to report the characteristics and trend of the rising proportion of young individuals being diagnosed with rectal and colon cancers at our institutions.

Patients and Methods

This study included 3381 rectal and colon cancer patients from the Mayo Clinic cancer registry from 1972 to 2017 who were diagnosed with rectal or colon cancer and who were < 50 years old. Patient and cancer characteristics are described. The Cochran-Armitage trend test was used to see if the change in percentage diagnosed at age < 50 years had a significant trend over the years. A linear regression model was fit to estimate the percentage change per year when the trend was approximately linear.

Results

The percentage of patients diagnosed with rectal or colon cancer in different age categories over the years showed a rising trend for individuals aged < 50. Most of these tumors were distal (rectum, left-sided colon, and right-sided colon were 49.8%, 28.8%, and 21.4%, respectively). This was more so for patients < 50 diagnosed with rectal cancer, which showed a linear increase at a rate of 0.26% per year (P < .001).

Conclusion

Our study affirms the rising proportion of colorectal cancers found in young individuals, with a linear ongoing rise of rectal cancers in particular. This may have implications for the current screening recommendations for colorectal cancers, which are already being revised.  相似文献   
98.
99.
《European urology》2014,65(2):329-336
BackgroundLarge randomized screening trials provide an estimation of the effect of screening at a population-based level. The effect of screening for individuals, however, is diluted by nonattendance and contamination in the trial arms.ObjectiveTo determine the prostate cancer (PCa) mortality reduction from screening after adjustment for nonattendance and contamination.Design, setting, and participantsA total of 34 833 men in the core age group, 55–69 yr, were randomized to a screening or control arm in the Rotterdam section of the European Randomized Study of Screening for Prostate Cancer (ERSPC). Prostate-specific antigen (PSA) testing was offered to all men in the screening arm at 4-yr intervals. A prostate biopsy was offered to men with an elevated PSA. The primary end point was PCa-specific mortality.Outcome measurements and statistical analysisNonattendance was defined as nonparticipation in the screening arm. Contamination in the control arm was defined as receiving asymptomatic PSA testing or a prostate biopsy in the absence of symptoms. Relative risks (RRs) were calculated with an intention to screen (ITS) analysis and after correction for nonattendance and contamination using a method that preserves the benefits obtained by randomization.Results and limitationsThe ITS analysis resulted in an RR of 0.68 (95% confidence interval [CI], 0.53–0.89) in favor of screening at a median follow-up of 13 yr. Correction for both nonattendance and contamination resulted in an RR of 0.49 (95% CI, 0.27–0.87) in favor of screening.ConclusionsPCa screening as conducted in the Rotterdam section of the ERSPC can reduce the risk of dying from PCa up to 51% for an individual man choosing to be screened repeatedly compared with a man who was not screened. This benefit of screening should be balanced against the harms of overdiagnosis and subsequent overtreatment.Trial registrationISRCTN49127736.  相似文献   
100.
IntroductionLiver transplantation is the only alternative treatment in patients in end-stage liver function. In many cases the need for liver transplantation is a consequence of the toxic effects of alcohol.The aim of our study was to determine if patients who are candidates for a liver transplant require a systematic exploration of the head and neck to rule out malignant lesions in this area.Patients and methodsAll the candidates for a liver transplant, between 2011 and 2017, were included in our study. All of them underwent a systematic exploration of the head and neck by an otolaryngologist to rule out malignancy of the head and neck.ResultsA total of 141 patients were included in our study. In 2 of them (1.3%) a carcinoma of the head and neck was detected (one of the oropharynx and the other of the larynx). Both patients were asymptomatic from an ENT point of view. They were treated with chemoradiotherapy. One of them died during follow-up due to the appearance of a metachronous lung tumour. The other is free of disease 2 years after diagnosis but without having been transplanted. Both patients had a history of smoking and high alcohol intake.ConclusionsIn patients who are candidates for a liver transplant who have a history of smoking and / or high alcohol intake, a pretransplant head and neck study including pharyngo-laryngeal fibroscopy is indicated.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号