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王刚 《内科急危重症杂志》2017,23(6)
【】目的:探讨联合检测血清基质金属蛋白酶组织型抑制因子(tissue inhibitor of metalloproteinase-4,TIMP-4)、可溶性E-选择素(soluble E- selectin,SES)、游离脂肪酸(free fatty acid,FFA)水平在预测慢性心力衰竭患者终点事件中的应用价值。 方法:选取2015年1月至2016年1月期间心内科住院部CHF患者120例作为研究组,同期另选取健康体检中心的正常人群120例作为对照组,全部患者使用双抗体夹心酶联免疫吸附试验(Double antibody sandwich enzyme-linked immunosorbent assay,DAS-ELISA)法测定血清TIMP-4、SES水平,使用免疫比浊法测定血清FFA水平。结果:研究组血清TIMP-4、SES、FFA水平明显高于对照组,比较差异具有统计学意义(P<0.05)。Pearson直线相关分析显示:TIMP-4与SES、FFA呈正相关(均P<0.001),SES与FFA呈正相关(P<0.001)。 相似文献
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Background
Prior studies have shown that children with congenital hearing loss have increased rates of behavior disorders. Child hearing loss has also been reported to be associated with increased maternal stress. Little is known about the behavior or the predictors of behavioral outcomes of children with hearing loss identified early and receiving Early Intervention services.Aim
The objective of this study was to identify the behavioral outcomes in early identified children with hearing loss and control hearing children at 18-24 months of age and to examine the impact of stress on early behavior development. It was hypothesized that children with hearing loss will have more behavior problems, and maternal stress will be associated with child behavior problems.Study design
Prospective observational.Subjects
Children with and without congenital hearing loss and their mothers.Outcome measures
The Parenting Stress Index and the Child Behavior Checklist.Results
Children with hearing loss had increased scores for withdrawn and internalizing behavior. In multivariate analyses after adjusting for hearing loss, Neonatal Intensive Care Unit stay, and socioeconomic status, maternal stress independently contributed to higher scores for internalizing behavior, externalizing behavior, and total behavior problems.Conclusion
Maternal stress is an important correlate of behavior problems for children with hearing loss and should be considered by Early Intervention providers. 相似文献85.
Claas MJ de Vries LS Bruinse HW van Haastert IC Uniken Venema MM Peelen LM Koopman C 《Early human development》2011,87(3):183-191
Background
Extremely low birth weight (ELBW) infants are at risk of cognitive impairment and follow-up is therefore of major importance. The age at which their neurodevelopmental outcome (NDO) can reliably be predicted differs in the literature.Aims
To describe NDO at 2, 3.5 and 5.5 years in an ELBW cohort. To examine the value of NDO at 2 years corrected age (CA) for prediction of NDO at 3.5 and 5.5 years.Study design
A retrospective cross-sectional and longitudinal cohort study.Subjects
101 children with a BW ≤ 750 g, born between 1996 and 2005, who survived NICU admission and were included in a follow-up program.Outcome measures
NDO, measured with different tests for general development and intelligence, depending on age of assessment and classified as normal (Z-score ≥ − 1), mildly delayed (− 2 ≤ Z-score < − 1) or severely delayed (Z-score < − 2).Results
At 2, 3.5 and 5.5 years 74.3, 82.2 and 76.2% had a normal NDO. A normal NDO at 2 years CA predicted a normal NDO at 3.5 and 5.5 years in 92% and 84% respectively. Of the children with a mildly or severely delayed NDO at 2 years CA the majority showed an improved NDO at 3.5 (69.2%) and 5.5 years (65.4%) respectively.Conclusions
The majority of the children with a BW ≤ 750 g had a normal NDO at all ages. A normal NDO at 2 years CA is a good predictor for normal outcome at 3.5 and 5.5 years, whereas a delayed NDO at 2 years CA is subject to change with the majority of the children showing a better NDO at 3.5 and 5.5 years. 相似文献86.
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Falkner B Gidding SS Ramirez-Garnica G Wiltrout SA West D Rappaport EB 《The Journal of pediatrics》2006,148(2):195-200
OBJECTIVE: To determine whether an association of overweight, or risk of overweight, and blood pressure can be detected in children in the pediatric primary care practice setting. STUDY DESIGN: We examined electronic medical record (EMR) data from primary care practices on 18,618 children age 2 to 19 years. Each child was classified on the basis of age- and sex-specific body mass index (BMI) percentile as normal weight (BMI < 85th percentile), at risk for overweight (BMI > or = 85th and < 95th percentile), or overweight (BMI > or = 95th percentile). BMI Z-score and height Z-score were computed. Systolic and diastolic blood pressures were compared among age-sex-BMI groups. RESULTS: Among children in primary care pediatric practices, 16.7% were at risk of overweight and 20.2% were overweight. With increasing BMI status there was a significant increase in both systolic blood pressure (P < .001) and diastolic blood pressure (P < .001). The association of higher blood pressure with increasing BMI status was present in all age groups. CONCLUSIONS: Clinical data from pediatric primary care practices verify the high prevalence of childhood overweight. The effect of overweight on blood pressure is present in childhood and can be detected even in children as young as 2 to 5 years. 相似文献
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Springer D Dziura J Tamborlane WV Steffen AT Ahern JH Vincent M Weinzimer SA 《The Journal of pediatrics》2006,149(2):227-232
OBJECTIVE: To investigate the impact of factors that might interfere with optimal glycemic control in youth with type 1 diabetes mellitus (T1DM) in the current era of intensive management, including the interplay of race/ethnicity and socioeconomic status (SES) on HbA1c levels. STUDY DESIGN: This study comprised a database review of all patients under age 18 years with T1DM for at least 6 months duration. Sex, age, race/ethnicity, duration of diabetes, mode of insulin administration (pump vs injection), body mass index, SES, and HbA1c level were recorded at each patient's most recent visit between January and September 2003. RESULTS: Mean HbA1c level for the 455 patients was 7.6% +/- 1.4%; only 31% of patients failed to meet the therapeutic goal of < 8.0%. Multiple linear regression analysis identified female sex (P = .02), older age (P = .001), longer duration of diabetes (P < .001), injection therapy (P < .001), and lower SES (P = .001) as significantly associated with higher HbA1c level. After adjustment for SES, race/ethnicity was not a determinant of HbA1c level. CONCLUSIONS: Low SES had a greater association with poor metabolic control than did race/ethnicity, which was not associated with differences in HbA1c level after controlling for SES. Most children were able to attain glycemic targets at least as good as the Diabetes Control and Complications Trial recommendations in a large clinical practice. 相似文献
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