全文获取类型
收费全文 | 85383篇 |
免费 | 5658篇 |
国内免费 | 2183篇 |
专业分类
耳鼻咽喉 | 477篇 |
儿科学 | 1332篇 |
妇产科学 | 731篇 |
基础医学 | 10293篇 |
口腔科学 | 1386篇 |
临床医学 | 6307篇 |
内科学 | 10269篇 |
皮肤病学 | 1709篇 |
神经病学 | 6450篇 |
特种医学 | 1654篇 |
外国民族医学 | 9篇 |
外科学 | 7250篇 |
综合类 | 10739篇 |
现状与发展 | 5篇 |
预防医学 | 6100篇 |
眼科学 | 873篇 |
药学 | 16016篇 |
9篇 | |
中国医学 | 4249篇 |
肿瘤学 | 7366篇 |
出版年
2023年 | 1184篇 |
2022年 | 2519篇 |
2021年 | 2762篇 |
2020年 | 1982篇 |
2019年 | 4775篇 |
2018年 | 4272篇 |
2017年 | 3026篇 |
2016年 | 2141篇 |
2015年 | 2622篇 |
2014年 | 4840篇 |
2013年 | 4955篇 |
2012年 | 4094篇 |
2011年 | 4669篇 |
2010年 | 4230篇 |
2009年 | 4642篇 |
2008年 | 3859篇 |
2007年 | 4546篇 |
2006年 | 4078篇 |
2005年 | 3288篇 |
2004年 | 2299篇 |
2003年 | 2267篇 |
2002年 | 1713篇 |
2001年 | 1393篇 |
2000年 | 1375篇 |
1999年 | 1120篇 |
1998年 | 1105篇 |
1997年 | 984篇 |
1996年 | 880篇 |
1995年 | 808篇 |
1994年 | 704篇 |
1993年 | 607篇 |
1992年 | 598篇 |
1991年 | 531篇 |
1990年 | 441篇 |
1989年 | 411篇 |
1988年 | 329篇 |
1987年 | 358篇 |
1986年 | 357篇 |
1985年 | 863篇 |
1984年 | 999篇 |
1983年 | 657篇 |
1982年 | 704篇 |
1981年 | 608篇 |
1980年 | 567篇 |
1979年 | 453篇 |
1978年 | 343篇 |
1977年 | 265篇 |
1976年 | 236篇 |
1975年 | 185篇 |
1974年 | 169篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
81.
82.
C. Knipfer F. Wagner K. Knipfer G. Millesi J. Acero J.A. Hueto E. Nkenke 《International journal of oral and maxillofacial surgery》2019,48(6):841-846
The aim of this study was to evaluate learners’ acceptance of a webinar for continuing medical education that was instigated by the International Association of Oral and Maxillofacial Surgeons (IAOMS). A live, interactive webinar on orthognathic surgery was broadcast via the Internet. The learners’ acceptance of the webinar was evaluated using a standardized, validated questionnaire (Student Evaluation of Educational Quality, SEEQ). One hundred and fifty-three participants attended the webinar; 55 participants (46 male, nine female) completed the questionnaire. The mean age of the respondents was 41.6 ± 10.0 years. The age of male and female respondents did not differ significantly. The respondents were spread over five continents, with the highest number from Brazil. The SEEQ showed a high level of acceptance for almost all subscales. There was no statistically significant difference between male and female respondents concerning acceptance of the webinar (P = 0.614). The wide distribution of participants shows the potential for webinars as facilitators of barrier-free distribution of knowledge. The webinar was well accepted by the attendees independent of sex, specialty, and work experience. However, the sex ratio reflects the underrepresentation of women in oral and maxillofacial surgery. 相似文献
83.
驱动基因的发现及针对驱动基因的靶向治疗已显著提高了肺癌患者的生存质量和时间,但目前对于BRAF、HER2、MET、RET等少见驱动基因改变肺癌患者的靶向药物的选择仍然较少。近年来免疫检查点抑制剂在肺癌治疗中取得了一定的疗效,但因为少见驱动基因突变的肺癌患者本身样本量少,开展大规模临床随机对照试验尚存在一定的困难,目前此类患者接受免疫检查点抑制剂治疗的疗效情况仍不明确。本文将对目前已掌握的免疫检查点抑制剂治疗BRAF、HER2、MET、RET等少见驱动基因改变肺癌患者的临床研究结果进行综述,以期在一定程度上为临床工作提供一些依据和参考。 相似文献
84.
85.
T.‐F. WANG S. W. HORSLEY K.‐F. LEE S.‐C. CHU C.‐C. LI R.‐H. KAO 《International journal of laboratory hematology》2006,28(3):160-163
Cytogenetic abnormalities are observed in approximately two‐thirds of patients with acute myeloid leukemia (AML). Chromosome rearrangements are associated with specific subtypes of AML and associated prognosis. We report a patient with AML, M2, who was primarily refractory to standard induction chemotherapy with idarubicin and cytarabine. Flow cytometry of a bone marrow aspirate showed aberrant expression of B‐cell markers including CD19. Cytogenetic studies disclosed a translocation between 5q35 and 11q13. Fluorescence in situ hybridization analyses demonstrated that neither the NSD1 nor MLL genes were involved in this case. Further study is required to define conclusively the genes involved and their contribution to pathogenesis in this case. 相似文献
86.
The use of endogenous Protoporphyrin IX generated through the heme biosynthetic pathway after administration of 5-aminolevulinic acid (ALA) has led to many applications in photodynamic therapy (PDT). In Buenos Aires, Argentina, the Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), reported for the first time, in 1975, porphyrin synthesis from ALA in highly dividing plant tissues. Increased porphyrin synthesis in tumours as well as cell photosensitisation was reported soon after. Our group is also interested in studying the use of new synthetic lipophilic derivatives of ALA as well as ALA delivery in liposomes. We have elucidated the mechanism of ALA transport in mammalian and yeast cells. The interactions between ALA-PDT and nitric oxide were investigated in three murine adenocarcinoma cell lines. In the National University of Río Cuarto, Córdoba, a group is devoted to the synthesis of new porphyrin-derived photosensitisers to study their effects on photoinactivation of bacterial and mammalian cells death by PDT. At the Centre of Electron Microscopy of the Cordoba National University, a prototype of a 630 nm noncoherent light source was designed and constructed. Cost of the light source and scarce knowledge of the benefits of PDT by physicians limit the spread of the treatment throughout the country. 相似文献
87.
88.
皮质发育障碍模型的建立及其致痫敏感性的研究 总被引:1,自引:0,他引:1
目的:建立皮质发育障碍模型,探讨皮质发育障碍模型的敏感性。方法:在SD大鼠孕17d腹腔注入1,3-二氯乙烯-亚硝基脲(BCNU)制作皮质发育障碍模型;Nissl染色观察P60d仔鼠病理变化;选取P60d雄性仔鼠,腹腔注射氯化锂-毛果芸香碱,分别比较两组大鼠癫发生的潜伏期、持续状态时间和死亡率。结果:同龄仔鼠脑组织湿重实验组比对照组显著减轻(P<0.01);Nissl染色显示皮质变薄、皮质层次紊乱、海马区域异位细胞异常聚集;有皮质发育障碍的仔鼠注射氯化锂-毛果芸香碱后,癫发生的潜伏期显著缩短(P<0.01),癫持续状态时间延长(P<0.01),死亡率显著升高(P<0.05)。结论:BCNU致皮质发育障碍模型具有癫易感性。 相似文献
89.
[目的]研究超敏C反应蛋白(hs-CRP)、总抗氧化状态(TAS)联合血脂检测在早老性痴呆症诊断中的应用价值:[方法]选择浦东新区精神卫生中心早老性痴呆专科门诊患者54例,作超敏C反应蛋白、总抗氧化状态与血脂检测。[结果]与对照组比较,实验组hs-CRP、TAS差异非常显著,t1=4.55,t2=2.79,P1〈0.001,P2〈0.01;血脂中甘油三酯、低密度脂蛋白胆固醇、载脂蛋白B、Lp(a)差异显著;t1=3.01,P1〈0.01,t2=2.21,P2〈0.05,t3=2.64,P3〈0.01,t4=1.91,P4〈0.05。[结论]超敏C反应蛋白、总抗氧化状态联合血脂(甘油三酯、低密度脂蛋白胆固醇、载脂蛋白B、Lp(a))检测对实验室诊断早老性痴呆症具有较好敏感性和特异性,临床应用前景乐观。 相似文献
90.