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91.
Tetsuya Sato Kaoru Sakado Sotoshi Sato 《European archives of psychiatry and clinical neuroscience》1993,242(5):273-278
Summary We investigated the frequency of personality disorders (PDs) and the relationship between the pressence of PD and the 4-month outcome of depression under adequate antidepressant therapy in a Japanese sample of 96 outpatients with non-bipolar major depression. The diagnosis of PD was made using a structured interiew method (the Structured Clinical Interview for DSM-III-R Personality Disorders) and after severe depressive symptoms were reduced. Any one kind of PD was found in 54.2% of the saple. The most frequent was avidant (34–4%), obsessived-compulsive (22.9%), narcisstic (18.8%), and dependent (16.7%) PDs. The frequencies of these PDs in our study except narcisstic PD, were about the same as those reported in previous studies with a matched setting for the PD diagnosis. Compared with patients without PD, a worse outcome was found in patients with PD, especially patients with multiple PDs from multiple PD clussters. There was no evidence that a specific PD or PD cluster especially worsens the outcome of depression. 相似文献
92.
We present an atypical case of peripheral nervous system (PNS) involvement in Sjogren's syndrome in a 63 year-old woman. Symptoms of an entrapment neuropathy were the first manifestation of the systemic disease and they were subsequently coupled to those of a mononeuritis multiplex. Clinical and laboratory signs for the diagnosis of Sjogren's syndrome became subsequently overt. The mononeuritis multiplex remained clinically limited to the upper limbs and characterized by unusually severe motor symptoms which progressed up to the development of a final complete deplegia. By contrast, sensory symptoms at the upper limbs remained mild over the entire course of the disease and the lower limbs revealed a subclinical sensory-motor damage only during the late stage. 相似文献
93.
综合医院精神科会诊患者失眠的临床研究 总被引:3,自引:0,他引:3
目的:探讨综合医院精神科会诊患者失眠的临床特征及与其它精神障碍的关系。方法:对168例精神科会诊患者进行分析。结果:128例(76、2%)会诊患者有失眠.其中61.7%(79/128)为慢性失眠。原发性失眠仅占5.5%(7/128),85.1%(109/128)是与其它精神障碍有关的失眠。常见的精神障碍诊断为焦虑障碍、心境障碍和谵妄。60.9%的失眠患者在会诊前得到了处理。结论:应对临床医师进行精神卫生教育,提高他们对失眠等常见精神障碍的识别和处理能力。 相似文献
94.
95.
96.
Fractures after Stroke 总被引:6,自引:0,他引:6
A. Ramnemark L. Nyberg B. Borssén T. Olsson Y. Gustafson 《Osteoporosis international》1998,8(1):92-95
Fractures are a serious complication after stroke. Among patients with femoral neck fractures, a large subgroup have had
a previous stroke. This study aimed to investigate the incidence of fractures after stroke. Included in the study were 1139
patients consecutively admitted for acute stroke. Fractures occurring from stroke onset until the end of the study or death
were registered retrospectively. Hip fracture incidence was compared with corresponding rates from the general population.
Patients were followed up for a total of 4132 patient-years (median 2.9 years). There were 154 fractures in 120 patients and
median time between the onset of stroke and the first fracture was 24 months. Women had significantly more fractures than
men (χ2 = 15.6; p < 0.001). In patients with paresis most of the fractures affected the paretic side (χ2 = 22.5; p < 0.001) and 84% of the fractures were cause by falls. Hip fracture was the most frequent fracture and the incidence was
2–4 times higher in stroke patients compared with the reference population. Fractures are thus a common complication after
stroke. They are usually caused by falls and affect the paretic side. It is necessary to focus on the prevention of post-stroke
fractures, including the prevention of both falls and osteoporosis. 相似文献
97.
David de Wied Jan M. van Ree 《European archives of psychiatry and clinical neuroscience》1989,238(5-6):323-331
Summary Animal studies have demonstrated that neuropeptides modulate nervous system functions. It has been postulated that disturbances in neuropeptide systems may be aetiological factors in psychiatric and neurological disorders. Neuropeptides related to ACTH/MSH, including ORG 2766, increase motivation and attention and facilitate recovery processes after nerve damage. These peptides may be effective during the early stage of dementia. Vasopressin and related peptides improve memory processes in animals and humans. In addition, these peptides influence social behaviour, mood and addictive behaviour. The non-opioid -type endorphins have neurolepticlike activities in animals and antipsychotic effects in a category of schizophrenic patients. Peptides related to CCK have also been found to be effective in these patients. Some neuropeptides, e.g. TRH and PLG, have been reported to exert antidepressant effects. Further research may eventually produce neuropeptides with therapeutic action in psychiatric and neurological diseases.Parts of this article were presented on the occasion of the inauguration ceremony of the Department of Psychiatry of the University of Mainz on April 2 and 3, 1987 相似文献
98.
Sylvestre Marchaux Paul Fornes Stphanie Petit Catherine Poisson Didier Thevenin Thierry Le Tourneau Philippe Asseman Patrick Bruneval Pierre-Vladimir Ennezat 《Cardiovascular pathology》2008,17(4):241-243
Myocardial dysfunction without coronary involvement may occur in acute cerebral diseases. The inverted Takotsubo pattern has been recently recognized as a novel heart neurologic stress-related syndrome. We report on the case of a 40-year-old woman presenting with massive subarachnoid hemorrhage and brain death. Echocardiography revealed an extensive left ventricular circumferential akinesis except at the apex. Histologic analysis of the heart confirmed the absence of myocardial infarction and revealed only sparse foci of myocyte necrosis with contraction bands in the akinetic areas. 相似文献
99.
Seema R. Lalani 《American journal of medical genetics. Part C, Seminars in medical genetics》2020,184(1):107-115
Congenital heart disease (CHD) is the common birth defect worldwide. Despite its recognized burden on public health, the etiology in the vast majority of individuals remains unknown. Chromosomal abnormality plays an important role, frequently observed as large cytogenetically visible rearrangement or small submicroscopic structural variation in the genome. Several genomic disorders are now recognized that are increasingly responsible for CHD with variable penetrance. Single gene disorders, epigenetic alterations, and environmental etiologies are also significant contributors. Our understanding of the genetic basis of CHD has increased exponentially with the escalating use of next generation sequencing to identify ever so small submicroscopic genomic imbalances at the level of coding exons in CHD. This review focuses on genomic disorders other than 22q11.2 deletion, that are major players in the etiology of human cardiac malformations. 相似文献
100.
S. Liendl C. J. Lauer R. M. Hoffmann 《Somnologie - Schlafforschung und Schlafmedizin》2004,8(3):67-70
Summary
Question of the study Sleep logs are common tools in sleep research and clinical routine. Usually sleep logs have to be completed during a 2-week
period, with the first week serving as an adaptation to the instrument itself. In the present study, we investigated whether
there is indeed such an adaptation bias or not.
Patients and methods A total of 236 chronically sleep-disordered outpatients completed the standardized sleep log ‘Abend-Morgen-Protokoll’ during
a 2-week pre-screening period prior to the first visit in our sleep ambulance. Two sets of items were established, the ‘instrumental’
and the ‘therapeutic’ set. The respective ratings of the first and second week (week A, B) were compared to evaluate clinically
relevant changes.
Results The ratings of several ‘instrumental’ items significantly differed between week A and B. However, these changes—on average—were
only marginal and therefore of little clinical importance. Regarding the ‘therapeutic’ set of items, no systematic variations
could be ascertained over the assessment period.
Conclusion The present investigation could not confirm the presence of adaptation biases (instrumental, therapeutic) in a large sample
of chronically sleep-disordered outpatients. Therefore, we consider a 1-week pre-screening period via sleep log as sufficient
for the diagnostic process in these patients.
相似文献