社区老年人心理健康状态调查

目的 探讨社区老年人的心理状态和生活质量。方法 采用老年人生活质量调查表及心理健康测查表（PHI）对416名社区老年人进行测查。结果 心理健康测查男性组和女性组各分量表除HMA外,社区老年人各量表分值明显高于常模,社区老年人与常模比较均有显著性差异（P〈0．01）。影响社区老年人生活质量的因素依次为心理卫生、健康状况、经济收入、生活习惯、居住条件和社会交往等。结论 社区老年人存在一定的心理问题和生活质量问题。积极治疗躯体疾病,宣传普及心理卫生知识有利于促进社区老年人的身心健康。     

门静脉高压症猪肝动脉的生物力学特性

目的：建立猪门静脉高压症模型,探讨门静脉高压症对肝动脉的生物力学特性的影响。方法：猪以四氯化碳、苯巴比妥、乙醇,配合高脂、低蛋白、低胆碱饮食进行混合饲养。通过脾静脉插管测压,取肝动脉在生物软组织力学试验机上测定其压力-直径关系,计算机图像分析测量肝动脉两端血管环的张开角及其几何形态学指标。结果：实验组门静脉压(4．17±1．03)kPa明显大于对照组(1．51±0．79)kPa,肝动脉的各向同性增量弹性模量、血管容积弹性模量和血管压力-应变模量均随压力的上升而增大,在相同压力下明显大于对照组。肝动脉的顺应性显著低于对照组,而张开角显著增加。结论：门静脉高压症时,肝动脉的生物力学特性发生了显著变化。     

1049例育龄妇女下生殖道感染情况调查

目的了解育龄妇女下生殖道感染情况,为育龄女性生殖健康提供进一步的数据资料。方法对1049例来自健康体检中心的21~40岁育龄妇女的阴道后穹窿及宫颈分泌物标本进行检测,阴道清洁度、滴虫采用显微镜镜检法,淋球菌、解脲支原体、人型支原体、真菌采用培养法,沙眼衣原体则采用免疫层析法。检测结果进行统计学分析。结果女性生殖道感染的感染率为53.3%,其中混合感染率为9.8%,而清洁度异常率仅为28.4%;前三位病原体感染依次为解脲支原体(35.9%)、衣原体(18.1%)、真菌(6.7%)。结论女性生殖道感染情况严重,具有隐匿性,应加强对无症状感染的育龄妇女的监测。     

基于HIS的医院体检信息系统的设计与开发

目的 设计一种符合体检要求且适应体检特点的工作流程。以提高工作效率及体检管理水平，使受栓人员轻松满意。方法 利用医院计算机网络系统，对体检中心工作站传入的受检人员信息进行系统化管理。结论 实践1年多以来，体检工作实现了规范化，系统化管理，加快了体检工作流程并提高了工作效率，为护士节省时间及减轻负担，较准确地达到了体验预期要求与目的。     

Elution behavior of insulin on high-performance size exclusion chromatography at neutral pH

The pharmacopoeia protocol for HP-SEC of insulin, using an acidic non-physiological eluent, does not represent insulin's association state in the formulation. This study aimed to evaluate insulin's elution behavior in HP-SEC in a “physiological” (aqueous, neutral pH) eluent, using on-line UV absorption and multi-angle laser light scattering detection. The effect of insulin concentration and association state in the formulation (monitored by circular dichroism) and eluent composition (zinc ion, arginine) on its elution behavior was assessed. We showed that the elution behavior of insulin in “physiological” HP-SEC is affected by both dynamic association–dissociation of insulin molecules and insulin–column interactions. Insulin molecules re-equilibrated in the HP-SEC eluent, making its elution behavior practically insensitive to the association state of insulin in the formulation. Zinc ions in the eluent promoted association of insulin to hexamers, whereas arginine overruled the effect of zinc ions and induced on-column dissociation of insulin to dimers and monomers. Combined results from “physiological” and compendial HP-SEC were shown to provide a better view of the aggregation state of heat-stressed insulin than either of the single methods. The insights obtained with this study are crucial for a proper evaluation of HP-SEC data of insulin.     

离子通道调整与新药研制——胃肠离子通道病研究最新进展

本文概述近年来尤其是最近5年,胃肠平滑肌和肠神经细胞离子通道及其与消化道疾病关系研究的最新进展,总结了可能用于新疗法、新药研制的新靶点,提出离子通道调整及修饰,应是今后与离子通道特性改变密切相关的功能性胃肠道疾病的诊治的方向。     

广州健康体检人员EB病毒感染状况调查分析

目的初步统计健康体检人员的EB病毒感染率,了解目前EB病毒感染的情况,总结在本地检测的阳性率。方法 EB病毒酶联免疫吸附法检测EB病毒IgA抗体。结果总结2007～2009年在我院进行的VCA-IgA抗体检查共36368例,共检查出1315例阳性,阳性率为3.6%。其中男性802例,女性513例,男女VCA-IgA抗体阳性率比例为1.56:1。运用SPSS13.0统计软件进行χ~2检验得出,2007～2009年50岁以上组与20～29岁组感染率比较,P<0.01,有统计学意义。结论年龄相差越大,VCA-IgA抗体检出阳性率差别就越大,检出阳性率随着年龄的增长而增多。建议在以后的预防保健工作中筛查重点人群是年龄在50岁以上人群。     

Ultrasound diagnosis of fetal head engagement

Objective

To compare clinical data and transperineal ultrasound results for the diagnosis of fetal head engagement.

Methods

The present prospective longitudinal study enrolled 100 term women attending the Mongi Slim Hospital, La Marsa, Tunisia, between July and September 2012. The clinical assessment of fetal engagement was compared with ultrasound measurements. Ultrasound examination was performed in the delivery room. The probe was placed on the ano-vulvar area. The measure used was the distance between the perineum and external table of fetal skull.

Results

The ultrasound measures of the perineum to external table of fetal skull ranged from 13 to 75 mm. The measures of the perineum to succedaneum bump ranged from 22 to 68 mm. A threshold of 55 mm was determined as the perineum to fetal head distance above which a diagnosis of engagement would be reversed. This proposed threshold had a positive predictive value of 98.6%, a sensitivity of 86.7%, and a specificity of 94.1%.

Conclusion

Transperineal ultrasound is a simple, rapid, and reproducible method for the diagnosis of fetal head engagement. It can be used in the delivery room in addition to clinical examination and when the latter is hampered by a succedaneum bump.     

Mise en place et évaluation d’un apprentissage par simulation des examens gynécologiques

ObjectivesTo report the setting-up of a new educational program in the teaching of female pelvic and breast examinations and to investigate and compare the views and experience of undergraduate medical students and teachers on the program.Patients and methodsProspective evaluation of the teaching program through completion of a satisfaction questionnaire including items related to the educational value of the session by the students and the teachers.ResultsThe educational program included an online preparation for the session, 3 workshops on training models (breast examination, pelvic examination, cervical snear procedure) and a video clip. In total, 419 (80.6%) of 520 second study year students (and 15 [50%] of 30 teachers [13 doctors and 17 midwifes] responded to the questionnaire). The students and the teachers were either very satisfied (56.6% and 13.4%, respectively) or satisfied (43.2% and 86.6%, respectively). On average, 89.7% of students wanted more lessons of this type and all teachers felt these useful or very useful training for students.Discussion and conclusionTeaching sessions for pelvic and breast examination, which make combined use of videos and training models, are associated with a high degree of satisfaction from teachers and students in their second student's year.     

原发性输卵管癌诊断方法

原发性输卵管癌(PFTC)是恶性程度很高的妇科肿瘤,具有症状隐匿、发病率低、诊断符合率低等特点。文章总结了当前应用于PFTC术前诊断的影像学特征及分子标记物等方法,并探讨了