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531.
J. P. Mäkelä L. McEvoy 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1996,110(3):446-454
Auditory motion can be simulated by presenting binaural sounds with time-varying interaural intensity differences. We studied the human cortical response to both the direction and the rate of illusory motion by recording the auditory evoked magnetic fields with a 122-channel whole-head neuromagnetometer. The illusion of motion from left to right, right to left, and towards and away from the subject was produced by varying a 6-dB intensity difference between the two ears in the middle of a 600-ms tone. Both the onset and the intensity transition within the stimulus elicited clear responses in auditory cortices of both hemispheres, with the strongest responses occurring about 100 ms after the stimulus and transition onsets. The transition responses were significantly earlier and larger for fast than slow shifts and larger in the hemisphere contralateral to the increase in stimulus intensity for azimuthal shifts. Transition response amplitude varied with the direction of the simulated motion, suggesting that these responses are mediated by directionally selective cells in auditory cortex. 相似文献
532.
We recorded spontaneous magnetoencephalographic (MEG) activity and somatosensory-evoked fields (SEFs) with a 24-channel planar SQUIDgradiometer in five patients with hemiparkinsonism. The SEFs of the patients were within normal limits. During tremorless periods, the spontaneous activity over the somatomotor cortex had a frequency peak at 10Hz in all five patients and another at 20Hz in three. Tremor dampened the 10-Hz activity in all patients; in three the effect was bilateral. Tremor did not increase MEG activity at the tremor frequency. The suppression of the μ rhythm by the parkinsonian tremor resembled that occurring during voluntary movements in healthy subjects. 相似文献
533.
Christo Pantev Thomas Elbert Bernhard Ross Carsten Eulitz Ernst Terhardt 《Hearing research》1996,100(1-2):164-170
The auditory system derives the pitch of complex tones from the tone's harmonics. Research in psychoacoustics predicted that binaural fusion was an important feature of pitch processing. Based on neuromagnetic human data, the first neurophysiological confirmation of binaural fusion in hearing is presented. The centre of activation within the cortical tonotopic map corresponds to the location of the perceived pitch and not to the locations that are activated when the single frequency constituents are presented. This is also true when the different harmonics of a complex tone are presented dichotically. We conclude that the pitch processor includes binaural fusion to determine the particular pitch location which is activated in the auditory cortex. 相似文献
534.
Contribution of the human superior parietal lobule to spatial selection process: an MEG study 总被引:3,自引:0,他引:3
The magnetoencephalographic signal was collected in a visually guided response-finger selection GO/NOGO task. The minimum norm distributed source analysis identified the sources in bilateral superior parietal lobules (SPL), with stronger activity for contralateral finger movement. Our results suggest that the human SPL plays a role in the spatial selection in a visuomotor task similar to that identified recently in monkeys. 相似文献
535.
Wang X Inui K Kakigi R 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2007,180(3):481-489
Lasers can selectively activate the nociceptors of A-delta fibers. Since nociceptors in the skin are activated via temperature
conduction by the laser beam, a latency jittering of cortical responses among trials would affect results obtained with a
conventional averaging (C-AVE) technique. We therefore used a new method, latency-adjusted averaging (L-AVE), to investigate
cortical responses to noxious laser stimulation in normal subjects. L-AVE was done by averaging trials after adjusting the
latency so that the peak latency of an activity in the temporal region of all trials matched on the time axis. Both in C-AVE
and in L-AVE, clear activations were found in the contralateral primary somatosensory cortex (SI) and bilateral parasylvian
regions, whose activities peaked 163–181 ms after the stimulation. In addition to these three main activities, weak activities
peaking at around 109–119 ms could be identified in only L-AVE in similar cortical regions. Since the direction of the source
differed between early and main activities, we considered that the early weak activities were cancelled out by the later main
activities with an opposite orientation. The results suggested that early cortical processing of noxious information occurs
earlier than previous neurophysiological studies have estimated and that the temporal sequence of activations should be reconsidered. 相似文献
536.
The purpose of this study was to study the relationship between interictal spike sources and somatosensory cortices in benign rolandic epilepsy of childhood (BREC) using a whole-scalp neuromagnetometer. We recorded spontaneous magnetoencephalography (MEG) and EEG signals and cortical somatosensory-evoked magnetic fields (SEFs) to electric stimulation of the median nerve in 9 children with BREC. Interictal rolandic discharges (RDs) and SEFs were analyzed by equivalent current dipole (ECD) modeling. Based on the orientation and locations of corresponding ECDs, we compared generators of RDs with primary (SI) and second somatosensory cortices (SII). Our results showed that RDs and SII responses had similar ECD orientation on the magnetic field maps. The ECDs of RDs were localized 15.3 +/- 1.9 and 12.2 +/- 2.8 mm anterior to SI and SII, respectively. The spatial distance on average from the location of RDs to SII (21.9 +/- 1.6 mm) cortex was significantly shorter than to SI cortex (29.7 +/- 1.7 mm) (P<0.01, Wilcoxon signed-rank test). In conclusion, the cortical generators for RDs in patients with BREC are localized in the precentral motor cortex, closer to hand SII than to SI cortex. 相似文献
537.
《Clinical neurophysiology》2021,132(8):1785-1789
ObjectiveTo determine whether magnetoencephalography (MEG) can identify epileptiform discharges mimicking small sharp spikes (SSSs) on scalp electroencephalography (EEG) in patients with temporal lobe epilepsy (TLE).MethodsWe retrospectively reviewed simultaneous scalp EEG and MEG recordings of 83 consecutive patients with TLE and 49 with extra-TLE (ETLE).ResultsSSSs in scalp EEG were detected in 15 (18.1%) of 83 TLE patients compared to only two (4.1%) of 49 ETLE patients (p = 0.029). Five of the 15 TLE patients had MEG spikes with concurrent SSSs in EEG, but neither of the 2 ETLE patients. Three of these 5 TLE patients had additional interictal epileptiform discharges (IEDs) in EEG and MEG. Equivalent current dipoles (ECDs) of MEG spikes with concurrent SSSs and IEDs showed no difference in temporal lobe localization and horizontal orientation, whereas ECD moments were smaller in MEG spikes with concurrent SSSs than those with IEDs.ConclusionsSSSs were more common in TLE than in ETLE. At least some morphologically diagnosed SSSs are true but low-amplitude epileptiform discharges in TLE which can be identified with simultaneous MEG.SignificanceSimultaneous MEG is useful to identify epileptiform discharges mimicking SSSs in patients with TLE. 相似文献
538.
Andreas V. Alexopoulos Salah Almubarak Yosuke Kakisaka Kazutaka Jin Dileep Nair John C. Mosher Imad M. Najm Richard C. Burgess 《Epilepsia》2013,54(2):359-369
Purpose: To investigate the utility of magnetic source imaging (MSI) and ictal single photon emission computed tomography (SPECT), each compared with intracranial electroencephalography (EEG) (ICEEG), to localize the epileptogenic zone (EZ) and predict epilepsy surgery outcome in patients with nonlesional neocortical focal epilepsy. Methods: Studied were 14 consecutive patients with nonlesional neocortical epilepsy who underwent presurgical evaluation including ICEEG, positive MSI, and localizing subtraction Ictal SPECT coregistered to MRI (SISCOM) analysis. Follow‐up after epilepsy surgery was ≥24 months. ICEEG, MSI, and SPECT results were classified using a sublobar classification. Key Findings: Of 14 patients, 6 (42.9%) became seizure‐free after surgery. Sublobar ICEEG focus was completely resected in 11 patients; 5 (45.5%) of them became seizure‐ free. Concordance of ICEEG and MSI and complete focus resection was found in 5 (35.7%) patients; 80% of them became seizure‐free. Sublobar ICEEG‐MSI concordance and complete focus resection significantly increased the chance of seizure freedom after epilepsy surgery (p = 0.038). In contrast, of the 6 patients (42.9%) with concordant ICEEG and SISCOM and complete focus resection, only 66.7% became seizure‐free (p = 0.138). Assuming concordant results, the additive value to ICEEG alone for localizing the EZ is higher with ICEEG‐MSI (odds ratio 14) compared to ICEEG‐SISCOM (odds ratio 6). Significance: This study shows that combination of MSI and/or SISCOM with ICEEG is useful in the presurgical evaluation of patients with nonlesional neocortical epilepsy. Concordant test results of either MSI or SISCOM with ICEEG provide useful additive information for that provided by ICEEG alone to localize the EZ in this most challenging group of patients. When sublobar concordance with ICEEG is observed, MSI is more advantageous compared to SISCOM in predicting seizure‐free epilepsy surgery outcome. 相似文献
539.
Janet McGraw Fisher Jacqueline Liederman Jami Johnsen Alexis Lincoln Richard Frye 《Laterality》2013,18(3):340-360
Dyslexic readers (DRs) manifest atypical patterns of brain activity, which may be attributed to aberrant neural connectivity and/or an attempt to activate compensatory pathways. This paper evaluates whether differences in brain activation patterns between DRs and typical readers (TRs) are confounded by task difficulty. Eight DRs and eight TRs matched for age, sex, and nonverbal IQ performed pseudoword rhyming tasks at two levels of difficulty during magnetoencephalography. Task difficulty varied with the number of successive target pseudowords presented before the test pseudoword. Regions of interest were: the temporoparietal area (TPA), the ventral occipital temporal area (VOT), and the inferior frontal gyrus (IFG). Activity was analysed for the 660-ms period after test pseudoword onset. During the discrepant performance condition left hemispheric TPA activation increased across time for TRs, but not DRs, and IFG bihemispheric activation was greater in TRs by the end of the trial. During the equivalent performance condition no group differences in TPA or IFG activation were found. We argue that these results indicate that direct comparison of DR versus TR brain activity is confounded when DRs are more challenged than TRs. This highlights the importance of equating reading group performance during neuroimaging of reading-related tasks. 相似文献
540.
Doing two things at once is difficult. When two tasks have to be performed within a short interval, the second is sharply delayed, an effect called the Psychological Refractory Period (PRP). Similarly, when two successive visual targets are briefly flashed, people may fail to detect the second target (Attentional Blink or AB). Although AB and PRP are typically studied in very different paradigms, a recent detailed neuromimetic model suggests that both might arise from the same serial stage during which stimuli gain access to consciousness and, as a result, can be arbitrarily routed to any other appropriate processor. Here, in agreement with this model, we demonstrate that AB and PRP can be obtained on alternate trials of the same cross-modal paradigm and result from limitations in the same brain mechanisms. We asked participants to respond as fast as possible to an auditory target T1 and then to a visual target T2 embedded in a series of distractors, while brain activity was recorded with magneto-encephalography (MEG). For identical stimuli, we observed a mixture of blinked trials, where T2 was entirely missed, and PRP trials, where T2 processing was delayed. MEG recordings showed that PRP and blinked trials underwent identical sensory processing in visual occipito-temporal cortices, even including the non-conscious separation of targets from distractors. However, late activations in frontal cortex (> 350 ms), strongly influenced by the speed of task-1 execution, were delayed in PRP trials and absent in blinked trials. Our findings suggest that PRP and AB arise from similar cortical stages, can occur with the same exact stimuli, and are merely distinguished by trial-by-trial fluctuations in task processing. 相似文献