医疗设备维护管理信息系统的开发与研究

本文基于C Builder和SQLServer开发平台,介绍了设备维护管理信息系统的开发设计,实施及应用拓展,为医院对医疗设备的维护管理及科学决策作出积极探索。     

A sexually dimorphic ratio of orbitofrontal to amygdala volume is altered in schizophrenia.

BACKGROUND: Neuroanatomic sexual dimorphisms have been correlated with behavioral differences between healthy men and women. We have reported higher orbitofrontal cortex to amygdala ratio (OAR) in women than men. Although gender differences in schizophrenia are evident clinically and correlate with neuroanatomic measures, their relationship to OAR has not been examined. METHODS: Magnetic resonance imaging was performed in 31 neuroleptic-na?ve schizophrenic patients (16 men) and 80 healthy volunteers (34 men), aged less than 50 years. An automated tissue segmentation procedure was combined with expert-guided parcellation of orbitofrontal and amygdala volumes. RESULTS: Men with schizophrenia had increased OAR relative to healthy men, whereas women had decreased OAR. Increased OAR in men with schizophrenia reflected abnormally low amygdala volumes, whereas decreased OAR in women reflected abnormally low orbitofrontal volumes. Less severe negative symptoms were associated with increased OAR in men but with decreased OAR in women. In men, increased amygdala volume was associated with greater symptom severity, whereas in women higher volumes of both amygdala and orbitofrontal regions were associated with lesser severity of negative symptoms. CONCLUSIONS: These opposite OAR abnormalities, whereby men show feminization and women masculinization, suggest gender-mediated effects of the underlying neuropathologic processes. The correlations with symptom severity suggest that neuroanatomic abnormalities in OAR reflect compensatory brain changes.     

灌肠灵治疗慢性结、直肠炎68例临床观察

目的 :观察灌肠灵治疗慢性结、直肠炎的临床疗效。方法 :对 136例符合慢性结、直肠炎诊断标准的患者 ,随机分为灌肠灵治疗组与对照组各 6 8例。两组治疗均为保留灌肠 ,每日 1次 ,10d为 1疗程 ,共 2疗程。结果 :治疗组优于对照组 ,总有效率为 91.1%与 72 .1% ,P <0 .0 5。结论 :灌肠灵治疗慢性结、直肠炎是目前疗效较好的一种理想方法     

An alternative mechanism of actions for neuroleptic and antidepressant drugs

It has earlier been proposed by the author that the aetiology of schizophrenic symptomatology may be due to the presence of abnormally connected interhemispheric fibres which link specialised functions in the brains of schizophrenics that are not connected in normal subjects, and that the neuroleptic drugs may produce their action through a local anaesthetic-like effect in suppression of conduction in these fibres. This line of thought has been extended here to consider the possible mechanism of action of the neuroleptic drugs in more detail, as well as that of the tricyclic antidepressant drugs which are derivatives of the phenothiazine group. Pharmacological similarities with the local anaesthetics both structurally and functionally have been considered, as well as the effects that these drug groups may have in common with the lithium salts. It has been suggested that these drugs all produce their primary effect on cell membranes, though not necessarily at the synapse, that the time course of their clinical effect may correlate with their incorporation into various cell membranes within the CNS, and that they may thus bring about a fundamental alteration in cell membrane microstructure. The possible role of electroconvulsive therapy has also been considered. The corollary of this argument is that the affective disorders may be genetically determined diseases of cell membrane microstructure.     

Pineal atrophy and other neuroendocrine and circumventricular features of the naked mole-rat,heterocephalusglaber (Rüppell), a fossorial,equatorial rodent

Summary Quantitative aspects of the microanatomy of the pineal gland and other neuroendocrine and circumventricular structures were studied in a small, reproductively suppressed, female Naked Mole-rat from central Kenya, Africa. The atrophic pineal is the smallest in absolute size (0.002135 mm³) of any so far described in a species of rodent, and in size relative to body weight is second only to that of another tropical species. The subcommissural organ and posterior collicular recess are also relatively small and less well differentiated than those in most other examined rodent species. In contrast, the subfornical organ, OVLT and median eminence are large and well vascularized. It is concluded that the pineal in this species follows the previously described trend among rodents of relatively smaller size in species whose centers of distribution are in lower latitudes. Although the pineal is atrophic, the Naked Mole-rat still exhibits 24-hour and seasonally timed patterns of behavior and seasonal reproduction. However, in this species these events are probably cued by moisture, temperature and social factors rather than by photic information.     

水前房角镜学的使命

水前房角镜学是新建的眼科学的一个分野,为眼科疾患病人服务是她的使命。水前房角镜学的最大优点是其含金量能百分之百地转化为读者的受益。     

重症心脏瓣膜置换术的体外循环管理

目的:回顾性总结重症心脏瓣膜病置换术体外循环经验.方法:105例重症心脏瓣膜病患者,使用stockerⅢ型心肺机及膜式氧合器,体外循环中采用中度低温,预充白蛋白并附加人工肾超滤,心肌保护用高钾含血停搏液灌注.结果:105例患者均顺利脱机,无1例死亡.体外循环时间60～180 min,主动脉阻断时间60～120 min,所有患者均顺利脱离体外循环,心脏自动复跳86例,电击19例.结论:手术中加强心肌保护,可减低手术后的功能衰竭和并发症,并可有效提高手术成功率.     

益气温阳活血方对急性心肌梗塞模型大鼠左室重构的影响

目的:观察益气温阳活血方对心肌梗塞模型大鼠左室重构的影响。方法:结扎冠脉前降支造模,治疗组益气温阳活血方灌胃,治疗第8周后检测各组大鼠心脏重量指数、左室壁面积、左室腔面积、左室腔周长等。结果:中药组心脏重量指数、左室壁面积、左室腔面积、和膨胀指数均较模型组下降(分别为P<0.05,P<0.01,P<0.05,P<0.01)。结论:益气温阳活血方具有良好的防治心室重构作用。     

Comparison of characteristics of esophageal squamous cell carcinoma associated with head and neck cancer and those with gastric cancer

In ongoing reviews of 339 patients with surgically treated primary squamous cell carcinoma, there were 19 (5.6%) with concurrent gastric cancer and 11 (3.2%) with head and neck cancer. The incidences of intra-esophageal multiple occurrence of esophageal cancer are 27.3% and 26.3% in those with associated head and neck cancer and gastric cancer, respectively, and higher than 7.1% in those without such a concurrent cancer. There was no difference in the clinicopathological characteristics of those with concurrent head and neck and gastric cancers, except for the higher incidence of metachronous occurrence in the former. These findings suggest that, in cases of esophageal cancer associated with concurrent head and neck cancer and gastric cancer, intraesophageal multiplicity of the esophageal carcinoma is frequent and that preoperative serial evaluations is most important to design treatment and estimate the prognosis.     

闭合性脑外伤患者恢复后期的记忆研究

目的探讨闭合性脑外伤患者恢复后期的记忆障碍特点。方法用临床记忆量表对 2 0例闭合性脑外伤患者恢复后期及 2 0例正常人进行记忆测验。结果闭合性脑外伤患者恢复后期 5项分测验及记忆商均明显低于正常人对照组 ,MQ≤ 79的比例较正常人明显增高。结论闭合性脑外伤患者恢复后期有非常严重的记忆障碍 ,其回忆比再认受损更严重