全文获取类型
收费全文 | 19682篇 |
免费 | 1360篇 |
国内免费 | 709篇 |
专业分类
耳鼻咽喉 | 208篇 |
儿科学 | 681篇 |
妇产科学 | 342篇 |
基础医学 | 1640篇 |
口腔科学 | 209篇 |
临床医学 | 1967篇 |
内科学 | 5665篇 |
皮肤病学 | 382篇 |
神经病学 | 1278篇 |
特种医学 | 398篇 |
外国民族医学 | 1篇 |
外科学 | 1197篇 |
综合类 | 2726篇 |
一般理论 | 2篇 |
预防医学 | 2632篇 |
眼科学 | 343篇 |
药学 | 793篇 |
6篇 | |
中国医学 | 949篇 |
肿瘤学 | 332篇 |
出版年
2024年 | 58篇 |
2023年 | 464篇 |
2022年 | 983篇 |
2021年 | 1205篇 |
2020年 | 1134篇 |
2019年 | 890篇 |
2018年 | 872篇 |
2017年 | 797篇 |
2016年 | 797篇 |
2015年 | 815篇 |
2014年 | 1478篇 |
2013年 | 1687篇 |
2012年 | 1111篇 |
2011年 | 1258篇 |
2010年 | 1058篇 |
2009年 | 916篇 |
2008年 | 860篇 |
2007年 | 760篇 |
2006年 | 608篇 |
2005年 | 548篇 |
2004年 | 461篇 |
2003年 | 463篇 |
2002年 | 335篇 |
2001年 | 285篇 |
2000年 | 203篇 |
1999年 | 168篇 |
1998年 | 142篇 |
1997年 | 160篇 |
1996年 | 121篇 |
1995年 | 92篇 |
1994年 | 95篇 |
1993年 | 58篇 |
1992年 | 53篇 |
1991年 | 58篇 |
1990年 | 42篇 |
1989年 | 27篇 |
1988年 | 27篇 |
1987年 | 35篇 |
1986年 | 26篇 |
1985年 | 57篇 |
1984年 | 68篇 |
1983年 | 40篇 |
1982年 | 39篇 |
1981年 | 46篇 |
1980年 | 61篇 |
1979年 | 48篇 |
1978年 | 33篇 |
1976年 | 28篇 |
1973年 | 34篇 |
1971年 | 25篇 |
排序方式: 共有10000条查询结果,搜索用时 78 毫秒
91.
P A Zartner R P Handke A M Brecher M B E Schneider 《Europace : European pacing, arrhythmias, and cardiac electrophysiology》2007,9(3):192-193
A 4-year-old girl with post-surgical complete atrioventricular block received an epicardial dual chamber pacemaker system. During further growth intermittent exit block occurred, first misinterpreted as neurological seizures. The epicardial lead was replaced using a transvenous approach, and a pacemaker with an integrated home monitoring facility was implanted. After her discharge, a rise in the pacing threshold automatically initiated an event message. On the basis of this information, the patient was called in and imminent dislodgement of the ventricular lead was diagnosed by x-ray. The lead was repositioned and was found stable over 1-year follow-up. 相似文献
92.
Paolo R. Salvalaggio Katie Neighbors Susan Kelly Karan M. Emerick Kishore Iyer Riccardo A. Superina Peter F. Whitington Estella M. Alonso 《American journal of transplantation》2005,5(8):1868-1874
The Pediatric End-Stage Liver Disease (PELD) score was designed to reduce subjectivity in liver allocation and to advantage patients with a higher probability of waiting list mortality. The aims of this study were to determine the impact of PELD implementation for children with chronic liver disease and to assess whether PELD met its goal of standardization of liver allocation for children. This study used data reported to the United Network for Organ Sharing (UNOS) registry for children with chronic liver disease receiving primary cadaveric liver transplant between January 2000 and December 2001 (pre-PELD) and March 2002 and July 2003 (PELD). PELD reduced the percentage of children transplanted while in an intensive care unit and as status 1. A calculated PELD score was used for allocation in only 52% of recipients. Thirty percent were status 1 at transplant and PELD scores granted by exception were used for allocation in 18% of patients. There was regional variation in PELD score at allocation and use of exception scores with a significant relationship between PELD score and percentage of exception cases. Regional variation suggests that PELD has not resulted in standardization of listing practices in pediatric liver transplantation. 相似文献
93.
BACKGROUND: Seizure frequency is in abnormal distribution, and it is not enough to express the trend of concentration using means, and its median loses a lot of information, thus it lacks of a standard for evaluating the therapeutic effects based on seizure frequency.
OBJECTIVE: To establish a method for evaluating the therapeutic effects on anti-epileptic drugs using changes of interval and duration of seizure.
DESIGN: A prospective cohort study.
SETTING: Zhumadian Psychiatric Hospital.
PARTICIPANTS: Outpatients and inpatients suffering from epilepsy attending firstly visited Zhumadian Psychiatric Hospital from June 2001 to June 2002 were enrolled. They were diagnosed as epileptic according to the International Classification of Epileptic Seizure by International League Against Epilepsy (1981) based on the clinical history, physical examination, and investigations. The interval time was no more than 6 months. Informed consent was obtained from all the subjects, and the study was approved by the hospital ethical committee.
METHODS: ① For the first visit and each follow-up, the following data were recorded, including general demographic information, seizure type, the date and time of ictus, the duration of ictus, and inducement or situation related, according to which the following indexes could be calculated, including seizure styles, interval, duration, cluster frequency and cluster duration. The information from the first review was noted as annals A. The second interview was taken at the end of the evaluating period; the information from the second review was noted as annals B. The third interview was taken within two weeks after the second one; the information from the third review was noted as annals C. The annals B or the annals C were respectively compared with the annals A in the light of the same types or the same styles of the same patient. Summation of the scores of interval change and duration change of the same type or the same style and 5 of basic score was the score of a corresponding seizure type or a corresponding style of one patient. In order to test its reliability and validity, the score of change of frequency or duration plus 5 scores respectively was the score of frequency or duration. ② Reliability and validity were tested by calculating corresponding correlation coefficient with SPSS 11.0. ROC curve was used for developing diagnostic criterion of predicting therapeutic effects with SPSS 11.0.
MAIN OUTCOME MEASURES: ① Reliability and validity; ② Diagnostic criterion for predicting therapeutic effects one year later.
RESULTS: Totally 28 patients were involved in the final analysis of results. ① Reliability and validity were high: rinter-rater=0.98, rtest-retest=0.99, rconstruct validity=0.83. ② A total score > 6 was the optimal diagnostic criteria for predicting therapeutic effects one year later, in other words, a patient who scored more than 6 at the evaluating period may be seizure-free one year later.
CONCLUSION: It is a potential tool for evaluating epileptic therapeutic outcome, and it can be diffusely used in interrelated fields after being further validated. 相似文献
94.
Alexander Marcus Claudia Ammermann Marianne Klein Martin H. Schmidt 《European child & adolescent psychiatry》1995,4(1):46-54
Wilson's disease is a hereditary autosomal recessive disorder of copper metabolism. The corresponding gene locus has been localized on the long arm of chromosome 13. Three different clinical variants of the disease can be distinguished: hepato-cerebral, abdominal/hepatic, and central nervous type. The heterogeneity of symptoms can cause problems in differential diagnosis, especially when another concordant disorder can also explain the pathogenesis of symptoms. The case report of a young man who suffered from brainstem contusion demonstrates the possibilities of misinterpretation because presenting symptoms could be attributed either to traumatic brain injury followed by adjustment disorder or Wilson's disease. Clinical signs included leftsided hemiparesis, bilateral gaze direction nystagmus, marked dysarthria with consecutive pervasive mutism, choreo-athetoid movements, spasmodic torticollis and diplopia dependent on gaze direction. Slit lamp examination showed Kayser-Fleischer's corneal ring. EEG- and computer assisted tomography investigations revealed non-specific findings. The patient was treated with D-Penicillamine. Alternative treatment with oral zinc preparations is discussed.
Zusammenfassung Beim Morbus Wilson handelt es sich um eine autosomal rezessiv vererbte Störung des Kupferstoffwechsels. Der Genort konnte auf dem langen Arm des Chromosoms 13 lokalisiert werden. Klinisch können aufgrund ihrer Symptomatik drei Verlaufsformen (hepato-zerebraler, abdominalhepatischer und zerebraler Typ) unterschieden werden. Die Vielfalt der Symptome kann differentialdiagnostische Schwierigkeiten bereiten. Das Beispiel eines jungen Mannes mit einer traumatischen Hirnstammkontusion zeigt, wie die Diagnose der hepato-lentikulären Erkrankung dadurch erschwert wurde, daß die Pathogenese der Symptome durch die Hirnstammkontusion und darauf folgende Anpassungsstörungen erklärt worden war. Die Symptomatik bestand aus linksseitiger Hemiparese, lateralem Blickrichtungsnystagmus, Dysarthrie mit nachfolgendem universalem Mutismus, choreo-athetodischen Bewegungsstörungen, Torticollis spasmoidicus und blickrichtungsabhängigem Auftreten von Doppelbildern. Bei der Spaltlampenuntersuchung stellte sich der Kayser-Fleischer Ring dar. EEG- und computertomographische Untersuchungen erbrachten nur unspezifische Befunde. Die Behandlung erfolgte mit D-Penicillamin. Die alternative Behandlung mit oraler Gabe von Zinksalzen wird diskutiert.
Résumé La maladie de Wilson est une affection héréditaire autosomale recessive concernant le métabolisme cuivré. Le locus du gène a été situé sur le bras long du chromosome 13. Du point de vue clinique on distingue trois formes symptomatologiques: le type hepato-cérébral, hepato-abdominal et cérébral. La diversité des signes cliniques peut poser des problèmes de diagnostic différentiel, car d'autres affections peuvent se présenter avec cette même Symptomatologie. Nous rapportons ici l'exemple d'un homme jeune, porteur d'une maladie de Wilson et victime d'une contusion traumatique du tronc cérébral, dont les signes cliniques ainsi que les troubles du comportement pouvaient été autant rapportés à la contusion du tronc cérébral qu'à l'affection métabolique.La Symptomatologie comprenait une hemiparesie gauche, un nystagmus lateralisé, une dysarthrie avec mutisme secondaire universel, des mouvements choréo-athétosiques, un torticolis spasmodique et une diplopie dépendante de la direction du regard. L'examen à la lampe à fente permettait à mettre en evidence un anneau de Kayser Fleischer. L'EEG et le scanner cérébral ne montraient pas d'anomalies specifique.Le traitement a consisté en l'administration de D-Penicillamine. Traitment alternative avec les sels de zinc est discuté.相似文献
95.
某部队急性腹泻病监测报告 Ⅰ.流行病学部分 总被引:1,自引:0,他引:1
1991年6月~1992年5月在驻粤某部队进行了急性腹泻病的主动监测。年发病率为0.64~1.0次/人/年。发病率与相对湿度(X2)、气温(X3),特别是雨量(X1)的关系经多元回归分析表明呈正相关。y=1.98+0.02x1+0.02x2+0.07x3,r=0.8727,P<0.01。病例-对照研究结果提示,饭前、便后不洗手等生活习惯用腹泻发病有密切关系。26.3%的患者有淋雨、腹部受凉或感冒等 相似文献
96.
某幼儿园1991~2005年儿童传染病发病趋势分析 总被引:3,自引:1,他引:2
[目的]了解幼儿园儿童传染病发病情况和流行趋势,为制定传染病防治策略提供依据.[方法]统计幼儿园内每年发病儿童人数与当年9月份在园儿童人数相比得出当年各种传染病发病率,对传染病进行特征性分析,用统计软件SPSS11.0作u检验.[结果]幼儿园是儿童传染病易感者集中的场所,1年12个月均有传染病发生.9种常见传染病中,腮腺炎、水痘、手足口病的发病率居顺构前3位.与计划免疫相关的“病”未见发病.乙肝自1994年以来未有检出.手足口病自2000年首次发病,发病率居近4年来各种传染病发病率之首.[结论]有必要将流腮疫苗和水痘疫苗纳入计划管理.重视对手足口病的监测,将手足口病纳入幼儿园常见传染病的管理之中. 相似文献
97.
M. NISKANEN A. KARI P. NIKKI E. IISALO L. KAUKINEN V. RAUHALA E. SAARELA 《Acta anaesthesiologica Scandinavica》1994,38(6):587-593
Prognostic factors determining the outcome from intensive care were studied in 952 patients admitted to 25 Finnish ICUs after gastroenterologic emergency. Logistic regression analysis was used to create predictive models based on the APACHE II–system. The models were constructed by using data from a random two–thirds of the study population and validated in the remaining independent one–third together with the original APACHE II–index. The Acute Physiology Score, age, and a pre–existing liver disease were the three most important determinants of outcome. The inclusion of the TISS score describing the intensity of treatment into a model did not enhance the accuracy of the prediction. Our models were better calibrated than the original APACHE II–equation when tested by the goodness–of–fit –statistics. These statistical models may help the clinicians to predict the outcome for an individual patient by providing them information about the relative impacts of predictive factors or about the probability of death. These probabilities should be interpreted cautiously, taking into acount the limitations of statistical methods. This is especially important when assessing the highrisk patients. Their number in our study was too low for accurate outcome prediction. 相似文献
98.
Fear of falling and postural control in Parkinson's disease. 总被引:4,自引:0,他引:4
This study investigated the relationship between fear of falling (FOF) and qualitative and quantitative postural control in Parkinson's disease (PD). Fifty-eight nondemented PD patients were studied along with age-matched healthy controls. The degree of FOF was estimated using the Activities-specific Balance Confidence scale. Qualitative postural control was evaluated using a component of the Unified Parkinson Disease Rating Scale. Postural control was quantified, using centre of pressure measures obtained from a force plate, for eight standing balance tests of different challenges. The results showed that FOF was more evident for PD patients when compared with healthy individuals of similar age. Furthermore, FOF was significantly associated with a qualitative estimate of postural control in PD; individuals with PD who had a greater degree of posture impairment reported greater FOF. The results also showed that an estimate of FOF may help to explain quantitative postural instability in PD. FOF, when coupled with a qualitative estimate of postural control, was able to explain a greater amount of variation in quantitative balance performance for five of the eight balance tests. When considered independently, the qualitative measure of postural control, in general, could not well predict quantitative balance performance. The greater degree of FOF and its possible association with altered postural control suggests that FOF should be considered as an important, independent risk factor in the assessment and treatment of postural instability in patients with PD. 相似文献
99.
100.
L. Mirone M.D. L. Altomonte E. M. Ferlisi A. Zoli M. Magaró 《Clinical rheumatology》1997,16(1):99-100
Summary Only few cases of cardiac conduction disturbances and arrhythmias have been reported in Behçet's disease. We recently observed the case of a 16-year-old woman with Behçet's disease in whom cardiac arrhythmia became the main clinical symptom. This observation and a review of the literature led us to the conclusion that arrhythmia could represent the clinical manifestation of an underlying myocarditis due to Behçet's disease and can be regarded as a feature of cardiac involvement of the disease. 相似文献