Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls

Introduction

Serotonin has been extensively studied in relation to both personality features and suicidal behaviours.

Objective

In this study, we considered the association between the serotonin receptor 1A (HTR1A) and 2C (HTR2C) SNPs and personality traits, as measured by the Temperament and Character Inventory (TCI), in a sample of suicide patients and healthy volunteers.

Methods

The SNPs considered were, for HTR1A rs1423691, rs878567 and rs6295, and for HTR2C rs547536, rs2192372, rs6318, rs2428707, rs4272555 and rs1801412. The sample was composed of three groups: two German samples, consisting of a healthy control group of 289 subjects (42.6% males, mean age: 45.2 ± 14.9) and a psychiatric patient group of 111 suicide attempters (38.7% males, mean age: 39.2 ± 13.6), and an Italian sample, composed of 64 mood disorder patients (35.9% males, mean age: 43.0 ± 14.8). In the German samples all the SNPs were investigated, while in the Italian sample only the HTR1A rs6295 and the HTR2C rs6318 SNPs were considered.

Results

Controlling for sex, age and educational level, single markers and haplotypes were not or only marginally associated with personality dimensions.

Conclusions

Our study does not support the role of HTR1A and HTR2C gene variants on personality traits in both healthy volunteers and mood disorder patients.     

Do anorectic men share personality traits with opiate dependent men? A case-control study

BACKGROUND: Eating disorders (ED) and substance use disorders (SUD) display clinical and psychodynamic analogies. The co-diagnosis of a substance use disorder in male ED patients is frequent. Nevertheless, knowledge about the mutual predisposing factors or personality analogies is currently scarce and hypotheses are controversial. METHODS: The Temperament and Character Inventory (TCI) was used to assess 21 anorectic men, 79 heroin-dependent men, and 75 control men matched for age and education. RESULTS: Anorectic and opiate-addicted patients displayed higher Harm Avoidance and lower Self-directedness and Cooperativeness. Anorectic men displayed lower Reward Dependence and higher Persistence. Opiate addicts had higher Novelty Seeking and Self-transcendence. DISCUSSION: Anorectic and heroine-dependent subjects share personality traits related to anxiety, fearfulness and antisocial features. Nevertheless, the personality profile does not completely overlap and this could influence the choice of the "substance" of abuse and the related clinical differences between anorexia and heroin dependence.     

An interaction between the norepinephrine transporter and monoamine oxidase A polymorphisms, and novelty-seeking personality traits in Korean females

The personality traits associated with the noradrenergic system have not yet been clearly established. In the present study, we investigated the variable number of tandem repeats (VNTR) polymorphism of the norepinephrine transporter (NET) and monoamine oxidase A (MAOA), which are major components of the adrenergic system, to elucidate their relationship with personality. A total of 245 normal female Koreans (age 23.05+/-3.07 years, mean+/-SD) volunteered to take part in this study. They filled out a Korean version of the Temperament and Character Inventory (TCI) and were genotyped for the NET and MAOA-VNTR; the NET T-182C and MAOA-uVNTR polymorphisms were checked. We found significant main effect of NET genotype on novelty seeking (NS) score (F=5.43, p=0.021) and significant interaction between the NET and MAOA-uVNTR polymorphisms on NS score (F=11.06, p=0.001). However, there were no relationship between MAOA-uVNTR polymorphisms and NS score, and no association with other temperamental dimensions and these two polymorphisms. Our findings suggest that this functional polymorphism in the noradrenergic gene is associated with novelty seeking in Korean females.     

基于模糊识别理论的针电极肌电信号的辨识

针对针电极肌电信号的不确定性，提出了一种利用模糊识别理论辨识针电极肌电信号的方法，对前臂异常募集时的针电极肌电信号进行辨识，给出了模糊识别所需的特征量，隶属度函数和特征关系矩阵。与选取相同特征值和样本数量的贝叶斯分类器的对比实验表明，这种方法所需样本少，识别准确率高。     

飞行员妻子性格相容性与多项心理社会因素的关系

目的 研究妻子性格相容性 (charactercompatibility, CC)的影响因素,为开展飞行职业家庭有关婚姻的心理咨询和治疗工作提供依据。方法 飞行员夫妻同时进行有关心理健康水平、生活事件、社会支持、个性的心理学量表测评,同时也给予妻子性格相容性测评。结果 妻子的CC与自身个性中的神经质相关系数为 -0. 127;与自身SCL 90总分的相关系数为 -0. 156,与飞行员的为 -0. 176;与自身SLERS负性环境问题相关系数为-0. 158,与飞行员的为 -0. 189;与自身SSRS的总分相关系数为 0. 180、与飞行员的为 0. 136;多元逐步回归分析,前 5个变量的标准回归系数排序:妻子的躯体化症状 ( -0. 271)>飞行员的正性家庭问题( -0. 265) >妻子的正性学习问题( -0. 237) >妻子的负性家庭问题 (0. 225) >飞行员的正性学习问题( -0. 224)。结论 多项心理社会因素都会影响妻子的CC,提高妻子躯体健康水平,防止紧张性生活事件的发生则是最重要的。     

美容医学的术语学、元医学及分类学研究

根据医学术语学、元医学及医学分类的原理，概括论述了美容医学的名称、性质以及分类。认为“美容医学”应成为该学科的术语；美容医学的性质是科学、技术与艺术三者的统一，特别是美容医学的艺术性是由于其目的、手段、基础所决定的；从分类学上说，美容医学是按目的命名的，是临床医学扩展的产物。     

波特鸭茅在云南省的引种研究

波特鸭茅具有耐寒，耐贫瘠，瘠，耐牧，适口性好，持久性强等优点，云南省不同气候种栽培结果表明，该品种在云南省北亚热带至中亚热带生长表现优二多年生黑麦草和苇状羊茅，在温带地区与多年和黑麦草和苇状羊茅相近，但持久性和耐盆瘠能力更强，在高寒地区生长和如猫尾草。适宜的推广种植范围为暖温带至中亚热带。     

浅谈我院医学影像学专业特色的建设和发展

本文对医学影像学专业特色及其建设与发展进行了讨论。文中指出,医学影像学专业特色的建设与发展将根据其主要特色和培养目标,建立为此服务的课程体系,提供完善的培养条件,并以建设省级品牌专业为动力,进一步做好学科建设工作,使医学影像学专业的特色更加鲜明、更加突出。     

No association between 5-HTTLPR and harm avoidance in Korean college students

There have been numerous studies on the association between 5-HTTLPR (polymorphisms in the promoter region of the serotonin transporter gene) and anxiety-related personality traits, with conflicting results. In this study, we administered Korean version of the Temperament and Character Inventory (K-TCI) to a sample of 158 Korean college students and genotyped for the 5-HTTLPR in order to compare the TCI dimensional scores including harm avoidance according to the 5-HTTLPR genotype and sex. We could not find the association between 5-HTTLPR and harm avoidance and other TCI measures. Considering known allele frequencies differences of 5-HTTLPR among different ethnic groups, further cross-cultural studies with a larger sample would be needed.     

Character reflects one＇s marriage or attitude towards love-four different marriages in austen＇s ＂pride and prejudice＂

Marriage is a very important part in everybody＇s life. Different attitudes towards marriage and different concepts of marriage result in different marriages. Thus, some marriages are happy, some are sweet, some are bitter and some are despicable. This paper aims to give an account that character reflects one＇s marriage or attitude towards love, by making a comparison of the four different marriages in ＂Pride and Prejudice＂ .