It's a word: early electrophysiological response to the character likeness of pictographs

Using unfamiliar and meaningless pictographs that varied in their degree of similarity to Chinese characters, the current study tested whether the early electrophysiological response was modulated by character likeness. We measured P100 and N170 while 20 native Chinese speakers were viewing Chinese characters, drawings of objects, and pictographs. Comparisons across the three categories of stimuli showed that pictographs elicited a smaller N170 amplitude than did Chinese characters and a stronger N170 amplitude than did objects, but did not differ in the P100 amplitude from the other two categories. Within the category of pictographs, stimuli with a higher degree of character likeness elicited larger N170 amplitudes and shorter N170 peak latencies, and this effect was again not observed in P100. These results suggest that N170 is sensitive to visual stimuli's character likeness even though they are unfamiliar pictographs with no meanings or sounds.     

Temporal sequence of comorbid alcohol use disorder and anorexia nervosa

Women with eating disorders have a significantly higher prevalence of substance use disorders than the general population. The goal of the current study was to assess the temporal pattern of comorbid anorexia nervosa (AN) and alcohol use disorder (AUD) and the impact this ordering has on symptomatology and associated features. Women were placed into one of three groups based on the presence or absence of comorbid AUD and the order of AN and AUD onset in those with both disorders: (1) AN Only, (2) AN First, and (3) AUD First. The groups were compared on psychological symptoms and personality characteristics often associated with AN, AUD, or both using general linear models. Twenty-one percent of women (n = 161) with AN reported a history of AUD with 115 reporting AN onset first and 35 reporting AUD onset first. Women with binge-eating and/or purging type AN were significantly more likely to have AUD. In general, differences were found only between women with AN Only and women with AN and AUD regardless of order of emergence. Women with AN and AUD had higher impulsivity scores and higher prevalence of depression and borderline personality disorder than women with AN Only. Women with AN First scored higher on traits commonly associated with AN, whereas women with comorbid AN and AUD displayed elevations in traits more commonly associated with AUD. Results do not indicate a distinct pattern of symptomatology in comorbid AN and AUD based on the temporal sequence of the disorders.     

42例系统性红斑狼疮超声心动图特征分析

目的:分析系统性红斑狼疮(SLE)患者超声心动图特征.方法:用超声心动图检查42例SLE患者及42例正常人.测量包括收缩末期左心房前后径(LA)、舒张末期左心室内径(LV)、舒张末期右室内径(RV)、室间隔厚度(IVST)及左室后壁厚度(LVPWT).结果:SLE患者左房室及右室长大,瓣膜形态及功能损害,并常伴有心包积液,上述各项两组间相比均有极显著性差异(P<0.01).结论:超声心动图可作为评价狼疮性心肌受损程度及监测病情变化的重要手段.     

金元四大家论治消渴病思想浅析

金元四大家在继承前人学术思想的基础上,分别在论治消渴方面提出了各自的见解。刘完素从"三焦燥热怫郁结滞"论治,张从正遵"三消当从火断"论治,李杲从"血中伏火,津血不足"论治,朱丹溪从"阳实阴亏,气实血虚"论治,在对消渴病病机认识上各具特点,丰富完善了中医论治消渴病的理论体系。     

羚羊感冒胶囊的质量标准研究

目的:建立羚羊感冒胶囊的质量标准。方法:考察羚羊感冒胶囊的性状、显微特征,用薄层色谱(TLC)法对方中牛蒡子、桔梗、甘草、金银花进行定性鉴别,用高效液相色谱法对金银花中绿原酸进行含量测定。结果:显微特征明显;TLC斑点清晰、分离度好;绿原酸进样量在0.07952～0.99400μg范围内与峰面积积分值呈良好线性关系(r=0.9999),平均加样回收率为100.6%,RSD=1.41%(n=6)。结论:所用方法操作简便、专属性强,所建标准可用于羚羊感冒胶囊的质量控制。     

员工主观幸福感与性格优势及归属感的关系

目的探讨员工主观幸福感与性格优势及归属感的关系。方法采用发放问卷法对245名在职员工进行调查。结果①24个性格优势中的绝大多数人与主观幸福感呈正相关,归属感与幸福感及总性格优势均显著相关。r值分别为0.385和0.578。②归属感在性格优势与主观幸福感的关系中起着部分中介作用。结论那些有助于营造和谐人际关系、提升归属感的性格优势,更有助于提高幸福感的程度。     

首发与复发老年抑郁症患者的临床特征分析

目的 分析首发与复发老年抑郁症患者的临床特征异同点.方法 应用自制量表调查109例老年期首发抑郁症患者(老年首发组)与89例老年期复发抑郁症患者(老年复发组)的临床特征并进行比较.结果 老年首发组患者的激越、疑病症状、躯体症状和记忆减退,均显著高于复发组,差异均有统计学意义(P<0.05);老年首发组躯体症状中的心血管系统症状显著高于对照组,差异有统计学意义(P<0.05).结论 老年首发抑郁症不同于老年复发抑郁症,激越、疑病、躯体症状和记忆障碍等较为突出.     

河南省B群与D群志贺菌感染的流行病学与病原学特征对比研究

作为菌痢的病原体,B群和D群点贺菌仍然占有绝对优势,河南省自2003年就未再监测到A群或C群志贺菌株.     

Combination of the serotonin transporter and norepinephrine transporter gene promoter polymorphisms might influence harm avoidance and novelty seeking in healthy females

It has been demonstrated that the interaction between serotonin transporter (5HTT) and norepinephrine transporter (NET) functions affects each transporter function and behavior in studies using knockout mice model. In the present study, we examined the effects of the 5HTT and NET gene promoter polymorphisms on personality traits in 575 Japanese healthy subjects. The 5HTT (long/short, L/S) and NET (-3081 A/T) genotypes were identified by PCR methods, and personality traits were assessed by the Temperament and Character Inventory (TCI). Neither of the two polymorphisms affected any TCI dimension, but the interaction between them had significant effects on harm avoidance and novelty seeking in females. Subsequent analyses showed that the females with the combination of the SS genotype reducing 5HTT function and the TT genotype reducing NET function had higher harm avoidance and lower novelty seeking. The present study suggests that the combination of 5HTT and NET polymorphisms influences harm avoidance and novelty seeking in females.     

胰腺癌神经转移原位移植瘤动物模型的构建及其生物学特性研究

目的建立人类胰腺癌细胞系MIA PaCa—Ⅱ裸鼠胰腺原位移植瘤模型,观察神经侵袭情况,并研究其生物学特性。方法将MIA PaCa—Ⅱ细胞接种于裸鼠背部皮下和胰腺被膜下,建立皮下和原位移植瘤模型,分别于4、6、8周处死裸鼠行原位移植瘤病理学检查,HE和银染观察神经侵袭情况,对K—ras、C—erbB2、环氧合酶-2（COX-2）、前列腺干细胞抗原（PSCA）、p53、DPC4行SABC免疫组织化学染色。结果皮下移植瘤接种成瘤率为100％（10／10）,呈局限性生长,无脏器和神经转移。原位移植4、6、8周时成瘤率均为100％（10／10）,神经转移率分别为50％（5／10）、80％（8／10）和60％（6／10）,并可见多个脏器转移。MIA PaCa—Ⅱ细胞、皮下及原位移植瘤细胞对K—ras、C—erbB2、COX-2、PSCA呈阳性表达,且高于裸鼠正常胰腺细胞,而p53、DPC4表达则低于正常胰腺组织细胞。结论成功建立神经侵袭原位移植瘤动物模型,研究嗜神经转移以6周为宜。K—ras、C—erbB2、COX-2、PSCA高表达与p53、DPC4低表达可能参与了胰腺癌的发生。