Projections of Temperature-related Non-accidental Mortality in Nanjing,China

<正>The health effects of climatic changes constitute an important research area, yet few researchers have reported city-or region-specific projections of temperature-related deaths based on assumptions about mitigation and adaptation. Herein, we provide quantitative projections for the number of additional deaths expected in the future, owing to the cold and heat in the city of Nanjing, China, based on 31 global circulation models(GCMs), two representative     

妊娠妇女血清辅酶Q10水平与其新生儿出生体质量的关联性分析

目的：探讨妊娠妇女血清辅酶Q10（CoQ10）水平与新生儿体质量的关联性,阐明CoQ10对新生儿体质量的影响。方法：选取240例孕妇,应用酶联免疫吸附（ELISA）法测定孕妇血清CoQ10水平。根据新生儿体质量分为低体质量组、正常体质量组和巨大儿组,记录新生儿母亲血清CoQ10水平。根据产检妇女血清CoQ10第75百分位数分为CoQ10 ≥ 0.85μmol·L^-1组和CoQ10<0.85μmol·L^-1组,记录2组新生儿体质量。采用Spearman相关分析法分析孕妇血清CoQ10与新生儿体质量的相关性。结果：正常体质量组（0.91μmol·L^-1±0.41μmol·L^-1）和低体质量组（0.88μmol·L^-1±0.38μmol·L^-1）孕妇血清CoQ10水平高于巨大儿组（0.64μmol·^-1±0.23μmol·L^-1）,差异有统计学意义（t=7.04,P<0.05;t=7.25,P<0.05）;孕妇血清CoQ10水平与新生儿体质量呈负相关关系（r=-0.17,P=0.00）。CoQ10 ≥ 0.85μmol·L^-1组新生儿出生体质量（3209.08g±320.15g）低于CoQ10<0.85μmol·L^-1组（3823.81g±189.04g）,差异有统计学意义（P<0.05）。孕早期、孕晚期CoQ10水平和平均孕期CoQ10水平是影响新生儿体质量的因素（P<0.05或P<0.01）;孕早期、孕晚期CoQ10水平和平均孕期CoQ10水平是影响新生儿体质量的保护性因素（P<0.05）。结论：妊娠妇女血清CoQ10水平对其新生儿体质量有一定的影响。     

CXCL12/CXCR4在乳腺癌中的研究进展

CXCL 12与其受体CXCR 4通过信号转导机制介导乳腺癌的转移,并在乳腺癌的生长、增殖中发挥作用。阻断CXCR 4/CXCL 12可抑制乳腺癌的生长、进展及趋化性转移,CXCR 4/CXCL 12可望成为乳腺癌靶向治疗的新途径。     

Pulmonary nodules 10 mm or less in diameter with ground-glass opacity component detected by high-resolution computed tomography have a high possibility of malignancy

OBJECTIVES: For the histological diagnosis of small lung cancers of 10 mm or less in diameter (< or =10), resection by video-assisted thoracic surgery (VATS) with computed tomography (CT)-guided marking is feasible. One problem is that a small number of these pulmonary nodules are malignant. We retrospectively analyzed CT images of pulmonary nodules to find better criteria to select candidates for resection among patients with small pulmonary nodules. METHODS: Ninety-four patients with indeterminate peripheral pulmonary nodules underwent wedge resection by VATS. High-resolution CT using a 1.25 mm slice included the area of lesions. Nodules were classified by size (< or =10, 11 to 20, >20 mm) and whether they had a ground-glass opacity (GGO) component. RESULTS: The histology of all 94 nodules showed 52 primary lung cancers, 6 metastatic tumors, 5 benign tumors, 8 intrapulmonary lymph nodes, and 23 inflammatory nodules. Ninety-three percent of nodules larger than 20 mm, 75% of nodules 10 to 20 mm, and 43% of nodules < or =10 mm were malignant. Introducing a classification according to GGO component to nodules, malignancy was detected in 88% of nodules with a GGO component and in 30% of nodules without a GGO component among nodules < or =10 mm. Nodules < or =10 mm with a GGO component showed a statistically significant (p < 0.01) correlation with malignancy. CONCLUSIONS: Pulmonary nodules < or =10 mm with GGO should be considered to have a high possibility of malignancy and to be candidates for resection by VATS.     

The Influence of Recombinant Human Erythropoietin on Tumor Necrosis Factor α and Interleukin-10 Production by Whole Blood Cell Cultures in Hemodialysis Patients

Abstract: Impaired immunological response in hemodialysis (HD) patients, which leads to inappropriate cytokine production, is partially caused by the hyperstimulation of both T lymphocytes and monocytes/macrophages. Recent data suggest that human recombinant erythropoietin (rhEPO) may have an immunological action. The goal of our study was to estimate the influence of rhEPO treatment on the production of the inflammatory cytokine tumor necrosis factor α (TNFα) and antiinflammatory cytokin interleukin-10 (IL-10) in 10 HD patients receiving rhEPO for 6 months. The levels of cytokines were measured in the in vitro cultures of whole blood. The level of IL-10 increased in all treated patients during the therapy, and it was accompanied by a transitory decrease of TNFα. The results of our studies suggest that rhEPO may reduce the inflammatory process by decreasing production of TNF α and increasing production of IL-10.     

Intra-articular tibial plateau fracture characteristics according to the “Ten segment classification”

BackgroundCurrently existing classifications of tibial plateau fractures do not help to guide surgical strategy. Recently, a segment-based mapping of the tibial plateau has been introduced in order to address fractures with a fracture-specific surgical approach. The goal of the present study was to analyze incidence and fracture specifics according to a new 10-segment classification of the tibial plateau.MethodsA total of 242 patients with 246 affected knees were included (124 females, 118 males, mean age 51.9 ± 16.1 years). Fractures were classified according to the OTA/AO classification. Fracture pattern was analyzed with respect to a 10-segment classification based on CT imaging of the proximal tibial plateau 3 cm below the articular surface.Results161 Patients suffered an OTA/AO type 41-B and 85 patients an OTA/AO type 41-C tibial plateau fracture. Females had an almost seven times higher risk to suffer a fracture due to low-energy trauma (OR 6.91, 95% CI (3.52, 13.54), p < 0.001) than males. In 34% of the patients with affection of the medial tibial plateau, a fracture comminution, primarily due to low-energy trauma (p < 0.001), was observed. In type B fractures, the postero-latero-lateral (65.2%), the antero-latero-lateral (64.6%) and the antero-latero-central (60.9%) segment were most frequently affected. Every second type C fracture showed an unique fracture line and zone of comminution. The tibial spine was typically involved (89.4%). A typical fracture pattern of high-energy trauma demonstrated a zone of comminution of the lateral plateau and a split fracture in the medial plateau. The most frequently affected segments were the postero-latero-central (85.9%), postero-central (84.7%), and antero-latero-central (78.8%) segment.ConclusionPosterior segments were the most frequently affected in OTA/AO type B and C fractures. Acknowledging the restricted visibility of posterior segments, whose reduction and fixation is crucial for long-term success, our findings implicate the use of posterior approaches more often in the treatment of tibial plateau fractures. Also, low-energy trauma was identified as an important cause for tibial plateau fractures.     

Successful treatment for lung cancer associated with pulmonary sequestration

We encountered a 69-year-old man with lung adenocarcinoma and pulmonary sequestration. The cancer lesion was located in the left upper lobe, with sequestration of the left lower lobe. Left upper lobectomy was performed after induction chemoradiotherapy, but the sequestered lung lobe was preserved because the preoperative respiratory function was poor. Preservation of the sequestered lung during surgery for lung cancer should be considered in patients who have poor respiratory function and no signs of respiratory infection.