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1.
Influence of acetylcholine on neuronal activity of monkey amygdala during bar press feeding behavior
L zl L n rd Yutaka Oomura Yasuhiko Nakano Shuji Aou Hitoo Nishino 《Brain research》1989,500(1-2):359-368
Single neuron activity in the monkey amygdala was investigated during cue signalled conditioned bar press feeding behavior and the effects of electrophoretically applied acetylcholine (ACh) and atropine were analyzed. ACh increased the firing rate of one third of the neurons tested; these excitatory responses were inhibited by the muscarinic receptor antagonist atropine. No characteristic location of ACh-sensitive neurons was found, cells were diffusely distributed throughout the amygdala. Activity of ACh-sensitive neurons did not correlate with any particular event during the bar press feeding task. However, continuous application of ACh at low current intensity during the task significantly enhanced the task-related excitatory firing patterns, or markedly attenuated the inhibitory responses. Continuous application of atropine elicited or enhanced inhibitory response patterns. These results suggest that the cholinergic system of the monkey amygdala facilitates neuronal excitation but attenuates inhibition related to various phases of feeding behavior, such as to cue recognition, food aquisition and rewarding process. 相似文献
2.
An electron microscopic study of local anesthetic-induced skeletal muscle fiber degeneration and regeneration in the monkey 总被引:1,自引:0,他引:1
An electron microscopic study was done on abductor pollicis brevis muscles of 18 Rhesus monkeys after intramuscular injections of 0.75% bupivacaine, 2% mepivacaine, or 2% lidocaine + epinephrine. The muscles were examined for from 2 h to 28 days. Severe muscle fiber damage, consisting of breakdown of sarcolemma and myofibrils, was seen as early as 2 h. Phagocyte mediated fragmentation of the degenerating muscle fibers was at its peak during the third and fourth days. Myoblasts were abundant during the fourth day. Early myotubes appeared on the fifth and sixth days, and they matured during the second week. Satellite cells appeared alongside mature myotubes. Overall, the local anesthetic-induced breakdown and regeneration of skeletal muscle fibers in the monkey followed a course quite similar to that seen in the rat. 相似文献
3.
本实验表明,猕猴高脂造型22—28个月,其大脑中动脉(Middle Cerebral Artery:MCA)内皮发生水肿、细胞间隙变宽,局部破裂等改变,中膜平滑肌细胞增生、迁移。老年高脂组病损程度较重,且中央支也表现出类似改变。结果提示,高血脂可以引起脑动脉硬化性改变,且病损程度与年龄因素密切相关。 相似文献
4.
T. D. Aumann J. A. Rawson M. K. Horne 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1998,119(2):179-190
Extracellular single-unit recordings were made from cerebellar dentate neurones in two conscious monkeys trained to perform
wrist flexion and extension movement tasks that produced a range of static joint positions and dynamic velocities. The experiment
was designed to establish whether there is a relationship between the discharge of dentate neurones and movement kinematics.
The discharge patterns of 58 “wrist-related” neurones were correlated with joint position, duration of unidirectional movement
(referred to as duration of velocity) and amplitude of velocity (peak velocity). Significant (P<0.05) correlations were found between the level of tonic discharge and static joint position in 21 of 58 (36%) neurones.
Correlations between phasic discharge and at least one of the velocity variables were found in 17 of 43 (40%) neurones [7
of 43 (16%) showed a correlation between the duration of phasic excitation associated with movement and duration of velocity,
5 of 43 (12%) between the peak rate of phasic excitation and peak velocity and 10 of 43 (23%) between the number of discharges
in the period of phasic excitation and peak velocity]. We conclude (for reasons outlined in the Discussion) that there is
not a strong relationship between neuronal discharge and kinematic parameters of wrist movement in the dentate nucleus.
Received: 21 October 1996 / Accepted: 14 August 1997 相似文献
5.
H. Nishino Y. Oomura Z. Kardi S. Aou L. Lnrd Y. Kai A. Fukuda C. Ito B.I. Min C.P. Salamant 《Brain research bulletin》1988,20(6):839-845
Single neuron activities in the lateral hypothalamic area (LHA) were recorded during bar press feeding task in the monkey. First registered neurons were sorted into 2 groups, glucose-sensitive (GS) and glucose-insensitive (GIS) neurons, depending on their glucose sensitivity. Then firing variations to feeding, electrophoretically applied catecholamines and opiate, and to odor and taste stimuli were investigated. GS neurons responded to dopamine, noradrenaline and morphine more often than GIS neurons. In feeding task GS neurons responded during bar press (BP) and reward (RW) periods with long-lasting inhibition of firing and at cue tone (CT) with transient inhibition, while GIS neurons responded during BP and RW periods mainly with excitation and at cue light (CL) with excitation. A majority of GS neurons responded to both odor and taste stimuli more often than GIS neurons. Data suggest that these two kinds of neurons in the LHA may be involved in different functional aspects of feeding: GS neurons, mainly in internal information processing and reward mechanism, and GIS neurons, in external information processing and motor aspects. 相似文献
6.
The distribution patterns of choline acetyltransferase (CAT), as a marker for cholinergic neurons, and Calbindin-D28k (CaBP) immunoreactivities in the forebrain basal ganglia of the Japanese monkeyMacaca fuscata were compared. Similar distribution patterns of CAT and CaBP immunoreactivities were found in the medial septal nucleus (MS) and the nucleus of the diagonal band of Broca (DBB). Double-labeling fluorescence immunocytochemistry revealed that most, but not all, cholinergic neurons were CaBP-immunoreactive in the MS and DBB. The results suggest that CaBP may play a role in the septohippocampal cholinergic neuron system of the monkey. 相似文献
7.
Yamamoto T. Hassler R. Huber C. Wagner A. Sasaki K. 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1983,51(1):77-87
Summary Thalamic projections of the pallidum and the deep cerebellar nuclei were studied by unitary recordings as well as field potential analysis in the thalamus of squirrel monkeys (Saimiri sciureus) under sodium pentobarbital anesthesia.Stimulation of the pallidum produced a positive field potential preceded by incoming afferent fiber volleys in the thalamus. Spontaneous discharges of thalamic neurons were suppressed during this positive potential, and intracellular recordings from the thalamic neurons revealed that the time course of this field potential corresponded to that of the hyperpolarizing potential. The hyperpolarization was presumed to be a monosynaptic inhibitory postsynaptic potential by the short synaptic delay (about 0.5–0.7 ms) and responsiveness to high frequency stimulation (over 150 Hz). The positive field potential on stimulation of the external pallidal segment was distributed in L.po (VA) and the reticular thalamic nucleus around L.po, whereas that on stimulation of the internal segment was in V.o.a (the anterior basal part of VL) and in Z.o (upper part of VL). The projection of the external segment appeared to be less dense than that of the internal segment.The projection of deep cerebellar nuclei was situated in V.o.a, V.o.p (posterior part of basal part of VL), V.o.i (VLm), the intralaminar nucleus (CL), and some part of V. im (the rostral part of VPLo). Projections of the interpositus and dentate nuclei were distributed in a more anterior part than those of the fastigial nucleus. A certain topographical arrangement of the projections of these three nuclei was found in V.o.p, V.o.i and V.im. No significant overlap was detected between projections of the pallidum and the deep cerebellar nuclei within the thalamus. 相似文献
8.
W. R. Webster J. Servière D. Crewther S. Crewther 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1984,56(3):425-437
Summary Tone bursts produced bands of selective 2-[14C]-deoxyglucose labelling in the inferior colliculus (IC) of the awake monkey. Low tone frequencies produced labelling in dorsal regions and high tone frequencies produced labelling in ventral regions. The position of the bands coincided with the position of a single unit with a characteristic frequency, which was the same as the frequency producing the labelling. These findings indicate that the bands of labelling represent iso-frequency contours in IC. The iso-frequency contours extended across most of the nucleus and were oriented from dorsomedially to ventro-laterally at 20–30° from the horizontal and became more vertical anteriorly. The width of the contours was as narrow as 200 m, suggesting that the contours might represent 2 or 3 overlapping cellular laminae.Supported by research grants from the National Health and Medical Research Council of Australia and the Australian Research Grants Scheme 相似文献
9.
K. Sasaki H. Gemba 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1986,64(3):603-606
Summary Monkeys were trained to perform hand movements in a reaction time task with discrimination between positive (go) and negative
(no-go) light signals, and field potentials in various cortical areas were recorded and analysed with chronically implanted
cortical electrodes. As previously reported, areas such as the prefrontal, premotor and motor cortices were active in association
with simple visually-initiated, reaction-time hand movements. The caudal part of the dorsal bank of the principal sulcus was
found to be activated specifically on no-go trials during discrimination, and revealed a relatively sharp surface-negative,
depth-positive potential. The potential appeared at a latency of 110–150 ms, which was 150–210 ms earlier than the movement
onset on go trials. With reversal of the go and no-go signals, this potential was found to be recorded only on no-go trials,
irrespective of the colour used for the stimulus. It is suggested that the activity in the dorsal bank of the principal sulcus
is related to the judgement not to execute the movement and/or the suppression of motor execution. 相似文献
10.
Dr. H. Gemba K. Sasaki 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1984,55(1):26-32
Summary A monkey was trained to lift a lever by wrist extension in response to a light stimulus. During the learning process of the task over several months, field potentials related not only to the task performance but also to substitution and stimulation experiments were recorded with chronically implanted electrodes on the surface and at a depth of 2.5–3.0 mm in the prefrontal, premotor, motor and prestriate cortices. In the substitution experiment, an examiner lifted a lever for the monkey so that it was watching the light and rewarded without the hand movement. In the stimulation experiment, the same light stimulus was simply delivered to the monkey. In a naive monkey which lifted the lever independently of the stimulus, stimulus-locked potentials were evoked by the task experiment in those cortices except the motor cortex, but none was elicited by the substitution or stimulation experiment. In a welltrained monkey, the substitution and stimulation experiments induced almost the same potentials as those prior to the task movement in respective cortices except the motor cortex, in which the component of cerebellar-induced premovement potential was not observed during the substitution and stimulation experiments. At an intermediate stage of learning, the situation was intermediate between the naive and well-trained stages and most premovement potentials except those in the motor cortex were elicited by the substitution experiment in reduced sizes, but nothing by the stimulation experiment.The present study suggests that the neuronal circuits for the operantly conditioned movement are functionally organized and gradually consolidated in the learning process, and that the consolidation is made earlier for the circuit involving association and premotor cortices than the circuit including the motor cortex in the process. The circuit to the motor cortex via the cerebro-cerebellar interconnection is recruited only on the execution of movement. 相似文献