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Natalia Rompoti Pelagia Katsimbri Georgios Kokkalis Dimitrios Boumpas Ignatios Ikonomidis Konstantinos Theodoropoulos Dimitris Rigopoulos Evangelia Papadavid 《Dermatologic therapy》2019,32(5)
Several clinical studies demonstrated the safety and efficacy of the interleukin‐17 inhibitor secukinumab in the systemic treatment of moderate‐to‐severe psoriasis, as well as psoriatic arthritis (PsA) in adults, whereas real‐world data is limited. A single‐center clinical study was performed to evaluate in real‐world practice the efficacy of secukinumab up to Week 104 of treatment in moderate‐to‐severe chronic plaque psoriasis, including scalp and palmoplantar involvement, according to Physician Global Assessment (PGA), PASI75/90/100 and scalp, and palmoplantar PGA. Drug survival, the safety profile of secukinumab, and patient's quality of life were also assessed during a 2‐year observation period. Out of 83 patients included, 56.3% were biologic‐naïve, and 94% had scalp, 25.3% palmoplantar, and 43.9% joint involvement. At Week 16, PASI75/PASI90/PASI100 were observed in 83.8/70.0/46.3%, respectively. Scalp and palmoplantar PGA were rapidly improved, with 98.7 and 95.5%, respectively, reaching clear/almost clear skin at Week 16. After 104 weeks, drug survival was 74.5%. A significant improvement of the quality of life was observed. Biologic‐naïve patients without coexisting PsA benefited the most. Real‐world data demonstrated secukinumab efficacious in chronic plaque psoriasis, including specific locations such as scalp and palmoplantar psoriasis with a safety profile similar to that in clinical trials. 相似文献
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目的 对白介素17A抑制剂相关炎症性肠病(inflammatory bowel disease,IBD)不良事件的情况进行数据挖掘与分析,为临床安全应用提供参考。方法 收集2004年第一季度—2021年第四季度美国FDA不良事件报告系统(FDA Adverse Event Reporting System,FAERS)以司库奇尤单抗、依奇珠单抗和布罗利尤单抗为首要怀疑药物,不良事件为IBD、克罗恩病(Crohn’s disease,CD)和溃疡性结肠炎(ulcerative colitis,UC)的报告,采用报告比值比法(reported odds ratio,ROR)和比例报告比值比法(proportional reported odds ratio,PRR)对信号进行检测分析。结果 共收集到IBD相关报告2 578份,其中司库奇尤单抗2 286份(88%),依奇珠单抗289份(11%),布罗利尤单抗3份(1%),涉及银屑病患者810例。3种药物严重不良事件的发生率分别为32.47%,33.11%和33.33%,均以“住院/住院时间延长”为主。司库奇尤单抗[ROR=4.123,95%... 相似文献
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Effectiveness and safety of secukinumab in 69 patients with moderate to severe plaque psoriasis: A retrospective multicenter study
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J. F. Schwensen A. Clemmensen C. Sand R. Gniadecki L. Skov C. Zachariae L. Iversen M. Rasmussen S. F. Thomsen 《Dermatologic therapy》2017,30(6)
Secukinumab (anti‐IL17A) is effective as treatment for moderate to severe plaque psoriasis, but real‐life data on effectiveness and safety lack. We aimed to present real‐life data of all Danish patients treated with secukinumab (n = 69). At baseline, before initiation of treatment with secukinumab 300 mg (47.8%) or off‐label treatment with secukinumab 150 mg (52.2%), the median PASI score was 7.1. A total of 66.7% (34/51) and 52.9% (27/51) of patients still on secukinumab at week 12 achieved a PASI (Psoriasis Area and Severity Index)‐50 and PASI‐75 of 66.7% and 52.9%, respectively. A total of 83.0% (44/53) and 60.4% (32/53) of the patients had a PASI‐score < 5 and PASI‐score < 2, respectively, after 12 weeks on treatment with secukinumab. A third of the patients had secukinumab discontinued due to limited clinical improvement or adverse events (n = 23) within a median of 92 days (interquartile range 51–212 days). Notably, the majority of the patients may represent a particularly difficult‐to‐treat group of patients, as 92.8% had been refractory to other biologic treatment. A total of 26.1% (n = 18) experienced adverse events. Secukinumab appears to be an effective treatment option with a favorable side effect profile in patients with plaque psoriasis who are refractory to or have side effects of traditional biologic drugs. 相似文献
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《Expert Review of Clinical Immunology》2013,9(6):709-720
The treatment of psoriasis in pregnant women can be challenging. Psoriasis generally improves during pregnancy; however, many pregnant patients still require treatment. In treating pregnant patients, the benefits of treatment and risks to the mother and the fetus must be considered. For localized psoriasis, topical corticosteroids are the treatment of choice. Other topical agents that are approved for the treatment of psoriasis, such as topical tar products and topical tazarotene, should be avoided during pregnancy because of unclear risks of teratogenicity. For moderate-to-severe psoriasis, ultraviolet B phototherapy is preferred. Despite limited safety data, biologics are favored over other systemic medications when needed. While there are new treatment options for psoriasis, there is limited information on the safety of medications during pregnancy. 相似文献