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61.
Toshiko Miyata Mika Yashiro Miyuki Hayashi Kouju Kamata Kensei Katsuoka 《The Journal of dermatology》2012,39(12):1006-1009
Pyoderma gangrenosum (PG) shows characteristic non‐infectious ulcers that are commonly associated with systemic diseases such as inflammatory bowel diseases, myeloproliferative disorders or aortitis syndrome. The typical clinical appearance is undermining ulcers with reddish and irregular borders on the legs. As PG has these notable signs, the diagnosis is relatively easy and its treatment depends on the severity of underlying complications. We report a case of a 60‐year‐old Japanese man, diagnosed with bullous PG, who also had been suffering from myeloperoxidase antineutrophil cytoplasmic antibody‐positive microscopic polyangiitis and pulmonary aspergillosis. This case displayed soft whitish ulcers that existed on the rough ulcer base, with irregular borders, on his bilateral dorsal hands. Initially, it seemed to be cutaneous secondary aspergillosis because the host was already infected with pulmonary aspergillosis in both lungs. The differential diagnosis of PG from aspergillosis was from the sterile bullae or neutrophilic bullae on his right forearm, which evolved into ulcers in a few days. This case was finally diagnosed as bullous PG and a topical glucocorticoid was very effective to epithelize the ulcers in 2–3 weeks. 相似文献
62.
Masayuki Sakiyama Takashi Kobayashi Yuiko Nagata Norihiro Fujimoto Takahiro Satoh Shingo Tajima 《The Journal of dermatology》2012,39(12):1010-1015
Pyoderma gangrenosum (PG) is an ulcerative skin disorder characterized by neutrophilic infiltrations. PG is generally classified into four types: (i) ulcerative; (ii) pustular; (iii) bullous; and (iv) vegetative. Among them, bullous PG is known as a rare type. Herein, we report a case of bullous PG together with a summary of the 12 PG cases treated in our department over the previous 15 years, and we review 38 well‐documented bullous PG cases (65.8% female; aged 18–80 years [mean ± standard deviation, 51.6 ± 16.8]) in the published work, including the present case, from 1972–2011. Although the disease most frequently associated with PG is inflammatory bowel disease, bullous PG is most commonly associated with hematological disorders (25/38, 65.8%), which indicates the characteristic pathophysiology specific to bullous PG. 相似文献
63.
Phillip J. Eichhorn 《Dermatologic therapy》2001,14(2):102-110
ABSTRACT: Pyoderma gangrenosum (PG) is a chronic ulcerative skin disease with striking clinical features that may rarely involve internal organs, particularly the lung, liver, and spleen. Approximately 50% of PG patients have associated inflammatory, immune dysfunction, or neoplastic diseases. The various topical, systemic, and surgical treatment options for PG are reviewed here. Systemic corticosteroids plus immunosuppressive therapy are often required to successfully manage severe cases of PG. Practical treatment strategies are discussed along with their proper monitoring and potential adverse effects. Current treatment methods are empiric, and the optimum treatment regimen for this disorder requires future controlled clinical trials. 相似文献
64.
Uwe Wollina Theodor Karamfilov 《Journal of the European Academy of Dermatology and Venereology》2000,14(3):187-190
Pyoderma gangrenosum sometimes takes a recalcitrant course that is unresponsive to standard immuno-suppression with corticosteroids and/or cyclosporin A. In these cases improvement of painful ulcerations is a therapeutic challenge. We report a 17-year-old boy with severe pyoderma gangrenosum treated successfully with mycophenolate mofetil and autologous keratinocyte transplantation using an esterified hyluronic acid delivery system. 相似文献
65.
66.
We present here a case of pyoderma gangrenosum (PG) on the stump of an amputated leg. The patient was a 69-year-old woman who had both of her legs amputated due to acute arterial occlusion. An ulcer first appeared nine years later, after which point it continued to fluctuate in size. Complications included regional blood flow disorder at the amputated stump, diabetes, and secondary infection. Despite various therapies, the ulcer exacerbated, and hypoproteinemia, increased CRP, and fever were confirmed. The patient was diagnosed as having PG based on her clinical symptoms and because the ulcer did not respond to various therapies. The ulcer improved significantly in response to administration of 40 mg/day of prednisolone, and complete epithelialization was later achieved. Given the presence of multiple complications, it was extremely difficult to confirm PG. Therefore, it is important for physicians to consider PG as one of the causes of intractable ulcers. 相似文献
67.
骨髓增生异常综合征是一组起源于造血干细胞,以血细胞病态造血,高风险向急性髓系白血病转化为特征的异质性髓系肿瘤,其合并坏疽性脓皮病是一种罕见的情况,多意味着预后不良。现将天津中医药大学第一附属医院血液科收治的1例骨髓增生异常综合征合并坏疽性脓皮病诊疗进行整理,希冀能为临床的诊治提供新的治疗依据及理论思路。 相似文献
68.
Wildfeuer T Albrecht G 《Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete》1999,50(3):217-220
Vegetative pyoderma gangrenosum is a nonaggressive, chronic, superficial variant of pyoderma gangrenosum. Unlike classic ulcerative pyoderma gangrenosum, the lesions are less deep and not painful, and the borders are not undermined. The base of ulcers usually shows granulation tissue. The histopathologic findings are characterized by superficial granulomas. Cultures for fungal or bacterial infections normally are negative. Vegetative pyoderma gangrenosum is seldom associated with systemic diseases and often responds to simple modes of therapy. Our patient had a 10 years history of superficial ulcers on face, trunk and upper arms, whose general health was not impaired. A broad diagnostical evaluation showed no systemic diseases. The histologic pattern demonstrated a granulomatous dermatitis. After exclusion of other causes, we believe the patient has the vegetative form of pyoderma gangraenosum. There was no improvement with local treatment. Only systemic therapy with corticosteroids and later on cyclosporine led to healing. 相似文献
69.
S. SEEBERG B. BRINKHOFF E. JOHN I. KJELLMER 《Acta paediatrica (Oslo, Norway : 1992)》1984,73(4):498-504
The extent of staphylococcal colonisation and neonatal pyoderma was studied in 5 220 infants in two large Swedish hospitals in 1979–1982. A method for routine cord care with 4 % chlorhexidine detergent solution was evaluated in one hospital. Nursery colonisation with Staph, aureus and streptococci decreased significantly. The method proved to be clinically efficient for prevention of pyoderma in the nursery as well as for controlling staphylococcal infection after discharge from hospital. The combined use of a quantitative sampling method and phage-typing showed that most post-discharge lesions were nursery-derived. In one of the hospitals, daily cord care with 70 % ethanol failed to prevent streptococcal and staphylococcal omphalitis in the nursery whereas daily cord care with chlorhexidine reduced the incidence of omphalitis from 21 to 1 %. 相似文献
70.
Pyoderma gangrenosum,acne, suppurative hidradenitis (PASH) and polycystic ovary syndrome: Coincidentally or aetiologically connected? 下载免费PDF全文
Dubravka Zivanovic Iva Masirevic Thomas Ruzicka Markus Braun‐Falco Milos Nikolic 《The Australasian journal of dermatology》2017,58(2):e54-e59
The clinical triad of pyoderma gangrenosum, acne conglobata and hidradenitis suppurativa has been named PASH syndrome. Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism and inflammation. Hidradenitis suppurativa, like acne vulgaris, may be a feature of hyperandrogenism. Obesity may be associated with both hidradenitis suppurativa and PCOS. We describe a possible association between PASH syndrome and PCOS. 相似文献