全文获取类型
收费全文 | 10036篇 |
免费 | 1268篇 |
国内免费 | 176篇 |
专业分类
耳鼻咽喉 | 65篇 |
儿科学 | 471篇 |
妇产科学 | 68篇 |
基础医学 | 638篇 |
口腔科学 | 84篇 |
临床医学 | 718篇 |
内科学 | 1550篇 |
皮肤病学 | 176篇 |
神经病学 | 428篇 |
特种医学 | 122篇 |
外科学 | 785篇 |
综合类 | 839篇 |
现状与发展 | 2篇 |
预防医学 | 216篇 |
眼科学 | 4489篇 |
药学 | 483篇 |
1篇 | |
中国医学 | 289篇 |
肿瘤学 | 56篇 |
出版年
2024年 | 71篇 |
2023年 | 318篇 |
2022年 | 488篇 |
2021年 | 652篇 |
2020年 | 555篇 |
2019年 | 492篇 |
2018年 | 597篇 |
2017年 | 550篇 |
2016年 | 454篇 |
2015年 | 445篇 |
2014年 | 603篇 |
2013年 | 845篇 |
2012年 | 495篇 |
2011年 | 517篇 |
2010年 | 411篇 |
2009年 | 452篇 |
2008年 | 469篇 |
2007年 | 483篇 |
2006年 | 388篇 |
2005年 | 343篇 |
2004年 | 229篇 |
2003年 | 208篇 |
2002年 | 177篇 |
2001年 | 146篇 |
2000年 | 113篇 |
1999年 | 100篇 |
1998年 | 114篇 |
1997年 | 69篇 |
1996年 | 74篇 |
1995年 | 73篇 |
1994年 | 58篇 |
1993年 | 42篇 |
1992年 | 39篇 |
1991年 | 31篇 |
1990年 | 35篇 |
1989年 | 32篇 |
1988年 | 25篇 |
1987年 | 26篇 |
1986年 | 23篇 |
1985年 | 40篇 |
1984年 | 33篇 |
1983年 | 29篇 |
1982年 | 34篇 |
1981年 | 34篇 |
1980年 | 23篇 |
1979年 | 11篇 |
1978年 | 14篇 |
1977年 | 4篇 |
1976年 | 9篇 |
1975年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
Debbie Ehrmann Feldman Mirella de Civita Patricia L. Dobkin Pete Malleson Garbis Meshefedjian CiarÁn M. Duffy 《Arthritis care & research》2007,57(2):226-233
Objective
To document perceived adherence to treatment (taking medications and performing exercises) in patients with juvenile idiopathic arthritis (JIA) over a 1‐year period and to identify related factors.Methods
We surveyed parents of patients with JIA at the Montreal Children's Hospital and British Columbia's Children's Hospital in Vancouver. Parents were asked to respond to a series of questionnaires every 3 months over a 12‐month period. Perceived adherence was evaluated on a 100‐mm visual analog scale (VAS) in the Parent Adherence Report Questionnaire (PARQ). Parental coping, distress, child function, disease severity and duration, perceived helpfulness of treatment, problems encountered, and sociodemographic data were also assessed.Results
The mean age of our sample of 175 children was 10.2 years; mean age at diagnosis was 6.1 years and mean disease duration was 4.1 years. Perceived adherence to medications was consistently high, with average adherence at baseline, 3, 6, 9, and 12 months being 86.1, 91.7, 90.4, 92.0, and 88.8, respectively, on the PARQ VAS. Perceived adherence to exercise was lower but remained steady, with corresponding means of 54.5, 64.1, 61.2, 63.0, and 54.3, respectively. Using generalized estimating equation analysis, factors associated with higher perceived adherence to medications included perceived helpfulness of medications and lower disease severity; those associated with higher perceived adherence to exercise were younger age of the child, child involvement in responsibility for treatment, and higher perceived helpfulness of the treatment.Conclusion
Belief in helpfulness of treatment is associated with higher parental perceived adherence to treatment. 相似文献22.
Transient Macular Edema after Laser In-Situ Keratomileusis 总被引:8,自引:0,他引:8
Bin Yang Zheng Wang Guofu Huang Xing Liu Yunlan Ling Xiaoping ZhengZhongshan Ophthalmic Center Sun Yat-sen University Guangzhou China 《眼科学报》2003,19(1):20-24
Purpose: To investigate the macular changes induced by laser in situ keratomileusisc(LASIK) procedure.Methods: Optical Coherence Tomography (OCT) was used to examine 27 eyes of 15LASIK patients before surgery, and 1 day, 1 week, 1 month after surgery.Results: The mean thick iness of neuroepithelial layer of macula was (195 ±24)microns, (178± 16) microns 1 day and 1 month after surgery, respectively, while thebaseline was (174 ± 12) microns. The increase in macular neuroepithelial thickness wascorrelated with the degree of myopia, but not with the duration of suction or thepostoperative BCVA.Conclusion: Mild macular edema is common in the first month following LASIK,especially in high myopia. However, no association with loss of BCVA has beenestablished. Eye Science 2003; 19: 20 - 24. 相似文献
23.
B. Bagolini V. Porciatti B. Falsini G. Scalia M. Neroni G. Moretti 《Documenta ophthalmologica. Advances in ophthalmology》1988,70(1):37-43
Macular and paramacular electroretinograms in response to two adjacent checks (6 deg/side), alternating at constant mean luminance, were recorded in 34 normal subjects ranging in age from 16 to 74 years. The macular electroretinogram declines progressively in amplitude with age (R = –0.42; P = 0.013). The amplitude ratio between macular and paramacular responses tends to be independent of age (R = -0.21; P = 0.22).Age-related changes in the macular electroretinogram shown in our study are consistent with previous anatomical and functional studies, which indicate a deterioration of photoreceptors beyond 20 years of age. These results suggest a possible use of this technique for future studies on macular degeneration. 相似文献
24.
Interleukin-5 has a specific role in various eosinophilic activities. It is the predominant cytokine produces by activated T-lymphocytes isolated from patients with idiopathic hypereosinophilic syndrome. We studied a young patient suffering from idiopathic hypereosinophilic syndrome who presented with Horner's syndrome, peripheral neuropathy and skin ulcers. The IL-5 gene expression by CD4+ T-lymphocytes and the peripheral eosinophil count were raised. The skin ulcers continued to deteriorate despite a swift reduction of the IL-5 gene expression and peripheral eosinophil count following systemic corticosteroid treatment. We suggest that peripheral eosinophilia may not be responsible for the damage in skin lesions and more aggressive treatment may be required. 相似文献
25.
Antonio Fea Andrea Grosso Marilena Rabbione Federico Grignolo 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2007,245(2):315-317
Background Optic disc anomalies are frequently associated with Alagille syndrome. We report here the first case of a patient with Alagille
syndrome combined with optic pit and serous macular detachment.
Methods A male patient with Alagille syndrome was referred from the pediatric hepatology department for investigation of visual loss
in the right eye. Anterior segment examination showed evidence of posterior embryotoxon, confirmed by gonioscopic evaluation.
Dilated fundus examination revealed serous macular detachment and optic pit.
Results OCT 3 scans confirmed the clinical findings.
Conclusions Optic pit is uncommon and should prompt a search for genetic disorders or development abnormalities. The association between
the two syndromes in this patient might be due to failure of correct neuroectodermal development, for which a common genetic
pathway is likely. 相似文献
26.
Mario Casmiro MD 《Neurosurgical review》1998,21(1):43-47
A 70-year-old female presented with the clinical triad of normal pressure hydrocephalus (NPH) and senile tremor. Neuroimaging disclosed findings of both NPH and empty sella (ES). A ventriculoperitoneal shunt did not modify the clinical course except for a mild and transient improvement, and shunt malfunction occured later on. The association of NPH and ES may result from a common underlying mechanism such as transient increases in intracranial pressure. 相似文献
27.
Seiji Kinugasa Shuichi Tachibana Manpei Kawakami Tatsuhiko Orino Ryuichi Yamamoto Shinjiro Sasaki 《Surgery today》1998,28(3):335-338
(Received for publication on Nov. 14, 1996; accepted on May 12, 1997) 相似文献
28.
W. W. Dawson R. J. Ulshafer H. M. Engel G. M. Hope M. J. Kessler 《Documenta ophthalmologica. Advances in ophthalmology》1989,71(3):253-263
During (January) 1986–(May) 1988, we examined 272 eyes in 136 rhesus monkeys in the closed Cayo Santiago colony of the Caribbean Primate Research Center of the University of Puerto Rico. Seventy-eight eyes were less than 10 years of age. One hundred and ninety-four were aged 10–28 years. The fundi were examined and photographed. Fluorescein angiography was performed in some eyes. Selected cases were evaluated for acuity loss by recording of pattern-evoked retinal and cortical signals. Light and electron microscopy were used to evaluate the pigment epithelium of some animals. Thirty-eight percent of all eyes had posterior pole drusen. Incidence was highly age-related. When late-stage lesions were found, we did not see neovascularization, but late hyperfluorescence was consistent with degenerative scarring and atrophy. Electrophysiology demonstrated moderately reduced acuity in the presence of numerous macular drusen. Electrooculograms were low normal. Histopathology showed changes identical to those reported in human age-related macular degeneration. No eyes less than 10 years of age had confluent drusen or disciform-like lesions. The incidence of drusen in samples of some social groups was much higher than others. 相似文献
29.
Tokuhiro Ishihara Yoshimi Yamashita Yoshiko Okuzono Tadaaki Yokota Mutsuo Takahashi Toshiaki Kamei Fumiya Uchino Noboru Matsumoto Shiro Miwa Hisaichi Fuji Takeshi Kozaki 《Ultrastructural pathology》1985,8(1):13-23
By light and electron microscopy, we observed foamy cells in the spleens from a patient with hemolytic anemia due to red cell adenosine deaminase (ADA) overproduction, a patient with rheumatoid arthritis (RA) treated with gold, and patients with idiopathic thrombocytopenic purpura (ITP)
The foamy cells associated with red cell ADA overproduction were essentially similar to Gaucher-like cells described in patients with thalassemia, and it was suggested that the accelerated destruction of red cells was one of the factors responsible for the development of foamy cells. Foamy cells in ITP and RA were closely associated with an increased destruction of platelets in the spleen. Morphologic transitions between phagocytosed platelets and myelinlike materials were traced in these disorders. In RA, however, foamy cells were heterogeneous from an ultrastructural standpoint, with different cytoplasmic inclusions. In addition to myelinlike materials, dense bodies, vacuoles with flocculent materials, and gold were noted in most of foamy cells. As gold compounds are known to inhibit lysosomal enzymes, we surmise that an acquired disturbance in lysosomal digestion is partially responsible for the accumulation of intermediate metabolites.
In the pathogenesis of foamy cells associated with blood cell dyscrasia, the accelerated destruction of blood cells and/or acquired disorders in catabolic pathways within the macrophages are suggested to be the underlying mechanism of an intralysosomal accumulation of incompletely degraded cellular debris. 相似文献
The foamy cells associated with red cell ADA overproduction were essentially similar to Gaucher-like cells described in patients with thalassemia, and it was suggested that the accelerated destruction of red cells was one of the factors responsible for the development of foamy cells. Foamy cells in ITP and RA were closely associated with an increased destruction of platelets in the spleen. Morphologic transitions between phagocytosed platelets and myelinlike materials were traced in these disorders. In RA, however, foamy cells were heterogeneous from an ultrastructural standpoint, with different cytoplasmic inclusions. In addition to myelinlike materials, dense bodies, vacuoles with flocculent materials, and gold were noted in most of foamy cells. As gold compounds are known to inhibit lysosomal enzymes, we surmise that an acquired disturbance in lysosomal digestion is partially responsible for the accumulation of intermediate metabolites.
In the pathogenesis of foamy cells associated with blood cell dyscrasia, the accelerated destruction of blood cells and/or acquired disorders in catabolic pathways within the macrophages are suggested to be the underlying mechanism of an intralysosomal accumulation of incompletely degraded cellular debris. 相似文献
30.
A series of cards each containing a two dimensional array of identical Snellen "E's" was used to determine best eccentric visual acuity in patients with macular disease having Snellen visual acuity of 20/70 or worse. Each "full field E" card simultaneously presents the same letter to foveal and parafoveal areas. This test can therefore determine quickly if potentially useful vision is present in any area of the central visual field. In our study of 37 eyes, 70% demonstrated potential visual acuity at least two times better than visual acuity measured by conventional methods, and 20% demonstrated at least a fourfold improvement. This suggests that most patients with macular disease do not spontaneously employ their best remaining area of retina for fixation. 相似文献