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931.
Eighteen infants were entered into a randomized, placebo-controlled trial of dexamethasone therapy for chronic lung disease. Initial ventilation requirements were similar in the two groups, although all infants were in headbox oxygen on entry to the trial. The dexamethasone-treated infants showed a significantly more rapid improvement during the 1st week of treatment, although the overall duration of oxygen therapy was similar in both groups. Cranial ultrasound examination revealed new periventricular abnormalities in three out of the five dexamethasone-treated infants who had previously normal scans, compared with none of four similar placebotreated infants. A large trial, focussing on potential complications, is now needed. 相似文献
932.
K. Kozlowski 《Pediatric radiology》1974,2(1):61-64
A 4 8/12 years old girl with micromelic type of spondylo-meta-epiphyseal dysplasia is described. The spondylo-meta-epiphyseal dysplasias of micromelic type present a group of diseases with versatile clinical and radiographic findings. Marked shortening of stature with generalised spondylo-meta-epiphyseal changes in radiographic examination are a constant finding. No biochemical changes were yet reported. The difficulties of early recognition and classification of these cases are stressed. 相似文献
933.
Fibrous dysplasia is a benign disorder of bone, consisting of one or more foci of fibro osseous tissue within the matrix of the affected bone. Fibrous dysplasia usually effects the femur, tibia, ribs, and facial bones and is rarely seen in feet. An unusual case of fibrous dysplasia involving the third toe is presented. 相似文献
934.
Joyce Schwartz Victor Saldivar Fermin Tio Colette Kohler 《Fetal and pediatric pathology》1984,2(2):187-195
A newborn twin presented with a cardiac tumor; at autopsy microcystic dysplasia was found in the kidneys. The histology of the renal cysts were not unlike those found in many multisystem syndromes (e.g., Schwartz-Jampel, Ehlers-Danlos, and Jeune's asphyxiating thoracic dystrophy). No evidence of tuberous sclerosis or other phakomatoses were found. This case may alert other observers to carefully look for cystic dysplasia of the kidneys or other organs in association with cardiac tumors. 相似文献
935.
Ultrastructural findings supporting the angioblastic nature of the so-called adamantinoma of the tibia 总被引:1,自引:0,他引:1
Electron microscopy of a case of adamantinoma of the tibia shows features which support a mesenchymal angioblastic origin rather than epithelial. Comparison is made between tissue from this tumour and a squamous cell carcinoma of the femur arising in chronic osteomyelitis. In adamantinoma no desmosomes are found between tumour cells and their cytoplasmic ultrastructure shows features of mesenchymal cell type including evidence of pinocytic activity and bundles of filaments resembling hyperplastic endothelial cells. The stroma shows features similar to fibrous dysplasia of bone with fibroblasts, histiocytes and fibrolipoblastic lipid-laden mesenchymal cells. It is condluded that adamantinoma of the tibia should be considered to be an angioblastic tumour of bone. 相似文献
936.
Mary Webb Ambler 《Acta neuropathologica》1977,40(3):269-271
Summary Non-neoplastic foci of skeletal muscle cells are rarely noted within human central nervous system. This report describes two children with developmental anomalies and striated muscle in the leptomeninges. Embryological displacement of notochordal or prechordal mesoderm in certain types of craniovertebral-cerebral dysplasia may account for the origin, the restricted sites and the infrequent observation of leptomeningeal striated muscle cells. 相似文献
937.
H Obara C T Pappas W H Northway K G Bensch 《International journal of radiation oncology, biology, physics》1985,11(2):285-298
Prolonged inhalation of 80% oxygen, in contrast to 100% oxygen, has generally been assumed not to lead to significant pulmonary impairment. Two and six week old C57BL mice were systematically assessed by transmission and scanning electron microscopy for structural changes in the lung caused by inhalation of 80% and 100% oxygen from the first day of life, and the injury was quantitated morphometrically. Six weeks of continuous inhalation of 80% oxygen resulted in diffuse fibrosis of the gas exchanging parts of the lung superimposed on which were, in the 100% oxygen exposed mice, foci of coarse scarring. Lowering the inspired oxygen concentration from 100% to 80% appeared to reduce the mucosal injury more than the interstitial fibrotic response. This suggests that the most persistent alteration caused by chronic supplemental oxygen exposure below 80% will be interstitial fibrosis. 相似文献
938.
Intestinal neuronal dysplasia and its morphometric evidences 总被引:2,自引:0,他引:2
William A. Meier-Ruge Patrick C. Schmidt Franz Stoss 《Pediatric surgery international》1995,10(7):447-453
The aim of this study was to morphometrically objectify the characteristics of intestinal neuronal dysplasia (IND) B by optic electronic image analysis. Biopsies of 60 children divided into two age groups (8 ± 4 months and 4 years ± 20 months) were examined. Three groups (n = 20) were studied: (1) isolated IND B; (2) Hirschsprung-associated IND B (NAIND), and (3) normal controls. A histotopochemical lactic dehydrogenase (LDH) reaction was used for the morphometric measurement of ganglion size, nerve cell size, and number of nerve cells per ganglion. The submucous neural density was measured with an acetylcholinesterase reaction. The results showed no significant morphometric differences between isolated IND and HAIND. Aging caused an increase in ganglion and nerve cell size. The density of the submucous plexus decreased with age. All parameters measured were significantly different from normal controls. Giant ganglia with a high number of LDH-positive nerve cells (IND: > 7, controls: 4 ± 1 nerve cells/ganglion) were the most relevant diagnostic parameter of IND. The pathogenesis of a dysganglionosis is dominated by abnormal early, genetically caused laminin expression during embryonic life, blocking neuroblast migration (aganglionosis) and prematurely differentiating neuroblasts into myenteric (hypoganglionosis) and submucous plexus (IND). IND B, hypoganglionosis, and aganglionosis are different manifestations of an identical developmental abnormality in which IND is the weakest form. 相似文献
939.
J-S Schlenzig K Bervoets V von Loewenich H Böhles 《Acta paediatrica (Oslo, Norway : 1992)》1993,82(2):202-205
In a retrospective study, urinary malondialdehyde concentration in 45 preterm neonates (25–35 weeks' gestation) during their first month of life was measured by HPLC. Urine was collected on different days of life as a 3-h sample. The frequency of urine collection and measurement varied between one (n = 22) and seven times (n = 8) per child. The study group was divided into three categories according to birth weight: low-birth-weight infants (LBW) (n= 16), very low-birth-weight infants (VLBW) (n = 17) and extremely low-birth-weight infants (ELBW) (n=12). Urinary malondialdehyde concentration was highest in the ELBW group: 1.15 (0.66, 2.12) μmol/l (median and quartiles) versus 0.58 (0.34, 1.18) μmol/l in the VLBW and 0.60 (0.40, 1.06) μmol/l in the LBW groups (ELBW versus VLBW, p < 0.005; ELBW versus LBW, p<0.02). In oxygen-treated neonates, significantly higher malondialdehyde values were found compared to those without supplementary oxygen (0.89 (0.48, 1.74) versus 0.58 (0.32, 0.89) μmol/l; p < 0.005). Likewise, a higher malondialdehyde concentration was found in infants requiring mechanical ventilation (intermittent mandatory IMV or high frequency ventilation) compared to those breathing spontaneously (intermittent mandatory ventilation: 0.80 (0.42, 1.66); p < 0.05 and high frequency ventilation: 1.20 (0.83, 2.13); p < 0.001 versus 0.57 (0.33, 0.88) μmol/l). Malondialdehyde concentrations correlated significantly with FiO2 yalues of the individual patients (r = 0.22; p<0.02). Comparing urinary malondialdehyde concentrations in infants with and without bronchopulmonary dysplasia, a significantly higher malondialdehyde concentration was found in the former group (0.96 (0.51, 2.07) versus 0.60 (0.32, 0.98) μmol/l;p<0.005)). Infants with patent ductus arteriosus had a higher urinary malondialdehyde concentration than those without patent ductus arteriosus (1.04 (0.58, 3.78) versus 0.64 (0.36,1.20) μmol/l;p 0.05)). Malondialdehyde concentrations were also higher in infants with intracranial bleeding compared to those without (0.83 (0.46, 1.42) versus 0.56 (0.33, 1.10) μmol/l; p<0.02)). No significant differences in urinary malondialdehyde concentration were seen, either in relation to i v feeding with or without lipid emulsion or to medication administered. Native malondialdehyde concentration in seven commercial preparations of lipid emulsion after various periods of storage was fairly constant (12.3 ± 0.4 μmol/l) (mean ± SD). 相似文献
940.
Tribhuvan P. Yadav Smita Mishra Vijay K. Gupta Ram K. Gautam Hemanta K. Kar Minakshi Bhardwaj 《The Journal of dermatology》1995,22(8):606-610
We report a 5-year-old girl with partial anodontia, hypotrichosis, hyperpigmentation of the skin, absence of pilosebaceous structures, and long thin fingers. There has as yet been, to the best of our knowledge, no report of such a combination of features. A review of conditions combining ectodermal dysplasia (subgroup 1–2) with skin manifestations is presented. 相似文献