活血化瘀强度与气血双亏型胃癌转移率相关性机理探讨

本文回顾研究了益气生血方剂中活血化瘀强度与气血双亏型胃癌转移率之间的相关性,显示两者有较强的正相关,提示气血双亏型胃癌转移率随活血化瘀作用加强而增高。推测可能与本型胃癌血小板数量及聚集性下降、血浆纤维蛋白含量低及凝血抑制、纤溶增强易于肿瘤转移有关,且大多数活血化瘀方药具有抑制血小板聚集,抗血凝和增加纤溶的现代药理机制。进而建议气血双亏型胃癌,在血小板数量及聚集率明显下降、凝血时间明显延长及FDP高时,尽量降低方剂中活血化瘀强度,以避免促进肿瘤转移。     

输尿管软镜碎石术联合叶金排石胶囊治疗直径小于2 cm肾结石临床疗效分析

目的探究输尿管软镜碎石术联合叶金排石胶囊对直径<2 cm肾结石患者的临床疗效。方法回顾性选取2017年6月—2019年12月医院收治的直径<2 cm肾结石患者700例,按照患者来医院采取的治疗方式分为观察组和对照组,每组350例,其中对照组采取输尿管软镜碎石术治疗,观察组在对照组患者的治疗基础上给予叶金排石胶囊,观察对比两组患者的治疗有效率、排石效果(以首次治疗结石排净率、首次排石时间、碎石次数、排石周期表示)、肾功能恢复情况(患侧肾脏GFR、血清NGAL、β2-MG)、术后并发症情况、炎性因子表达水平(血清hs-CRP、IL-6、IL-10)。结果对照组的治疗有效率为90.29%(316/350),观察组为98.29%(344/350);对照组首次治疗结石排净率、首次排石时间、碎石次数、排石周期分别为59.71%(209/350)、(2.03±0.27)d、(2.43±0.39)次、(19.72±2.97)d,观察组患者分别为72.57%(254/350)、(0.98±0.12)d、(1.62±0.33)次、(12.52±1.97)d;对照组患者患侧GFR、血清NGAL、...     

阴式子宫瘢痕妊娠病灶清除术的临床疗效评价

目的 观察阴式子宫瘢痕妊娠病灶清除术治疗剖宫产术后瘢痕妊娠的意义.方法 选取我院2018年10月—2019年10月收治的64例剖宫产术后瘢痕妊娠患者的临床资料,根据手术方案的不同,将实施阴式子宫瘢痕妊娠病灶清除术的病例作为观察组(n=33),将选择腹腔镜子宫瘢痕妊娠病灶消除术的病例作为对照组(n=31).比较两组手术疗...     

Enhanced Nitrate Ions Remediation Using Fe0 Nanoparticles from Underground Water: Synthesis,Characterizations, and Performance under Optimizing Conditions

The presence of nitrates in water in large amounts is one of the most dangerous health issues. The greatest risk posed by nitrates is hemoglobin oxidation, which results in Methemoglobin in the human body, resulting in Methemoglobinemia. There are many ways to eliminate nitrates from underground water. One of the most effective and selective methods is using zero-valent iron (ZVI) nanoparticles. ZVI nanoparticles can be easily synthesized by reducing ferric or ferrous ions using sodium borohydride. The prepared ZVI nanoparticles were examined by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), electron microscopy (TEM), X-ray diffraction (XRD), Brunauer–Emmett–Teller (BET) surface area, and zeta potential. We aim to eliminate or reduce the nitrates in water to be at the acceptable range, according to the world health organization (WHO), of 10.0 mg/L. Nitrate concentration in water after and before treatment is measured using the UV scanning method at 220 nm wavelength for the synthetic contaminated water and electrochemical method for the naturally contaminated water. The conditions were optimized for obtaining an efficient removing process. The removal efficiency reaches about 91% at the optimized conditions.     

早期拔除尿管对腹腔镜下结肠癌术后镇痛患者的影响

目的 探讨腹腔镜下结肠癌术后镇痛期间拔除尿管对患者尿潴留及相关并发症的影响.方法 分析本院2014年1月至2015年12月腹腔镜下结肠癌术后留置镇痛泵的患者46例,其中实验组23例(留置镇痛泵期内拔除尿管),对照组23例(停用镇痛泵后拔除尿管).两组术后尿潴留率、尿路感染率、肺部感染率、伤口感染率及满意率等指标比较.结果 两组患者的尿潴留率(8.7％比4.3％)、肺部感染率(4.3％比8.7％)、伤口感染率(4.3％比13.0％),差异均无统计学意义(均P＞0.05).两组患者均未出现导尿管相关性尿路感染.实验组满意率78.3％高于对照组47.8％,差异有统计学意义(P＜0.05).结论 腹腔镜下结肠癌术后留置镇痛泵的患者早期拔除尿管是安全可行的,且能减轻留置尿管引起的不适.     

甲状腺素对豚鼠耳蜗毛细胞的保护作用

应用耳蜗外淋巴灌流技术、微电极技术及扫描、透射电镜技术，观察先服甲状腺素（10mg)三次后行外淋巴灌流卡那霉素（10^-3g/ml)1小时的豚鼠实验组（T／K）蜗内电位（EP），耳蜗微音电位（CM）和毛细胞的亚微结构变化，并与单纯灌流卡那霉素（10^-3g/ml)的豚鼠对照组（KM）进行比较，发现3组动物EP无明显差异；实验组（T／K）的CM下降较对照组（KM）少，两者有显著差异；实验组动物外毛细胞损伤较对照组动物轻，提示甲状腺素可能直接作用于听毛细胞，减轻卡那霉素对内耳的毒副作用。     

Recent Advances in Adsorptive Nanocomposite Membranes for Heavy Metals Ion Removal from Contaminated Water: A Comprehensive Review

Water contamination is one of the most urgent concerns confronting the world today. Heavy metal poisoning of aquatic systems has piqued the interest of various researchers due to the high toxicity and carcinogenic consequences it has on living organisms. Due to their exceptional attributes such as strong reactivity, huge surface area, and outstanding mechanical properties, nanomaterials are being produced and employed in water treatment. In this review, recent advances in the use of nanomaterials in nanoadsorptive membrane systems for wastewater treatment and heavy metal removal are extensively discussed. These materials include carbon-based nanostructures, metal nanoparticles, metal oxide nanoparticles, nanocomposites, and layered double hydroxide-based compounds. Furthermore, the relevant properties of the nanostructures and the implications on their performance for water treatment and contamination removal are highlighted. The hydrophilicity, pore size, skin thickness, porosity, and surface roughness of these nanostructures can help the water permeability of the nanoadsorptive membrane. Other properties such as surface charge modification and mechanical strength can improve the metal adsorption effectiveness of nanoadsorptive membranes during wastewater treatment. Various nanocomposite membrane fabrication techniques are also reviewed. This study is important because it gives important information on the roles of nanomaterials and nanostructures in heavy metal removal and wastewater treatment.     

毛囊细胞混合物移植诱导裸鼠毛囊样结构形成

目的 观察毛囊细胞复合物移植诱导裸鼠毛发再生和毛囊重建情况.方法 采用裸鼠移植技术,将混合分离出来的毛囊细胞,包括毛囊毛乳头细胞、毛囊外根鞘细胞、毛囊真皮鞘细胞和毛囊真皮成纤维细胞等,移植到裸鼠皮下,观察毛囊形成情况.结果 在裸鼠的皮肤切片中可以看到较为完整的毛囊结构形成.结论 毛囊细胞混合物可以在体内诱导出毛囊样结构形成.     

对苯二胺氧化产物对小鼠经皮肤染毒的亚慢性毒性

[目的 ]研究氧化型染发剂主要成分对苯二胺 (PPD)氧化产物经皮吸收后对小鼠的亚慢性毒作用。 [方法 ]对苯二胺经双氧水氧化后的氧化产物为受试物 ,每隔 3d在小鼠背部皮肤染毒 1次 ,周期 1个月。整个过程中观察小鼠的一般生长情况 ,并于染毒 1个月后观察受试动物血生化指标、血常规、肝肾脾组织病理学改变和遗传毒性。 [结果 ]PPD氧化产物可影响小鼠的肝肾功能 ,随着PPD染毒剂量增加 ,ALT和BUN值逐渐增高 ,与对照组比较差异有显著性 (P<0 0 5或P <0 0 1)。PPD具有遗传毒性 ,能造成骨髓细胞染色体和DNA的损伤 ,并在受试剂量范围内存在剂量 效应关系。 [结论 ]频繁使用氧化型染发剂可能对机体具有潜在的危害     

锁定钢板螺钉取出困难原因及解决方法的探讨

目的探讨锁定钢板螺钉取出困难的原因和解决方法。方法回顾分析10例锁定钢板螺钉取出困难患者的临床资料。结果螺钉取出困难的原因：钢板应力变形,锁定螺丝孔道变形,旋入螺钉时未使用卸力限制工具,螺钉内六角打滑,取钉方法错误。结论锁定钢板螺钉内固定及取出时应严格规范操作,使用专用工具及方法,可顺利取出内固定,并避免医源性骨折。