表现为泛发性环状红斑的梅毒一例

患者,男,57岁.躯干、股部、双手掌见泛发性环状红斑,无脱屑,伴痒痛3个月.实验室检查梅毒非特异性抗体(TRUST)阳性1:128,梅毒特异性抗体(ELISA法)阳性.苄星青霉素240万U分两侧臀部肌注,每周1次,共3次病情好转.     

复发性疼痛性红斑1例

患者女,67岁,胸前、腹部反复红斑伴疼痛4年.皮损组织病理示:表皮轻度萎缩变薄,灶状基底细胞液化变性,真皮少量单一核细胞浸润.诊断:复发性疼痛性红斑.     

330例慢性光化性皮炎患者紫外线最小红斑量测定

目的:分析慢性光化性皮炎(CAD)患者与长波紫外线(UVA)、中波紫外线(UVB)的关系,以及最小红斑量(MED)的影响因素.方法:以SUV1000型日光紫外线模拟器作为照射光源,比较330例CAD患者不同性别、年龄、病程及不同季节受试者UVA-MED值及UVB-MED值.结果:男性患者UVB-MED值明显低于女性ME...     

Erythema induratum of Bazin in a 10‐year‐old boy

Erythema induratum of Bazin (EIB) is a form of tuberculid resulting from hypersensitivity to tuberculosis antigen. EIB occurs most commonly in middle‐aged women and is not typically seen in children. Here, we present a rare case of EIB, presenting as a chronic nodular panniculitis, in a 10‐year‐old Korean boy.     

A preliminary investigation into the effect of exposure of photosensitive individuals to light from compact fluorescent lamps

Summary Background  Compact fluorescent lamps (CFLs) are due to replace common incandescent lamps over the next few years. There has been no investigation of the possible effect of this on patients with photosensitive disorders. Objectives  To determine the effect of exposure of photosensitive individuals to light from CFLs. Methods  The spectral emission from a sample of CFLs was measured using a calibrated spectroradiometer. The erythemal response was determined in one normal individual and four photosensitive individuals by direct exposure of the skin to light from a CFL. The susceptibility of a wider group of photosensitive individuals was predicted based on the light dose known to elicit a reaction during phototesting at discrete ultraviolet (UV) wavelengths. Results  CFLs emit UV radiation at wavelengths down to 254 nm. Prolonged exposure of a normal individual’s skin produced erythema. However, an exposure of only 2·5 min at 5 cm elicited marked erythema in one of the abnormally photosensitive patients. Conclusions  CFLs could be a source of harmful UV radiation to photosensitive individuals. Patients with chronic actinic dermatitis are thought to be at greatest risk. The use of a protective envelope is recommended.     

A study of a method for distribution analysis of skin color

Background/aims: The objective and quantitative assessment of the skin is important in medical and cosmeceutical research. Assessment of color is an important element for analyzing the surface of the skin, which is usually determined subjectively by a doctor or using color analysis devices. These devices, however, cannot provide correct color information because color is construed from the mean value of the observation region, and analysis of color distribution is impossible. The purpose of this paper is to develop an objective analysis method to permit skin color measurement of each pixel unit of an image and analyze the distribution of skin surface color. Methods: The Skin Color Distribution Analyzer (SCDA) is an analysis method newly developed at the Research Institute for Skin Image at Korea University. The SCDA system presented in this paper performed a novel form of quantitative and objective analysis of skin color distribution using each pixel color model parameter found in image wavelength information. In this paper, distribution analysis was conducted on normal skin and skin lesions and skin affected by artificially induced irritant contact dermatitis and pigmented nevous. The method selected a grade using a color model parameter. Twenty healthy Korean males participated in this study. A comparative study of the eight anatomical areas was performed, including the exposure and non‐exposure parts and the medial aspect and the lateral aspect of the forearm. A reliability test for the SCDA system was also conducted with a spectrometer (SPEC) using the color analysis method. Results: Each skin lesion was precisely segmented by grade and each parameter hada different statistical significance for results of analysis of distribution in pigmented nevous and the artificially induced irritant contact dermatitis. Parameters L^*, b^*, a^*, and EI showed salient traits. Showed resemble measured result in the SCDA system and the SPEC of normal skin. The exposed site, in comparison with the non‐exposed site, showed a notable difference in the L^* parameter and a significant statistical difference in the x and z parameters, except b^*. The comparison of the medial and lateral aspects of the forearm showed a notable difference in the L^* parameter and a significant statistical difference in the parameters except y and b^*. In the reliability test result using the SCDA system and the SPEC, the SCDA system was highly reliabile in terms of the CV value in all color model parameters. Conclusions: The color distribution analysis method using the SCDA system has revealed an aspect that the existent method of medical research has not shown, and is considered to be more reliable than other methods. This method can provide better study findings because it can be applied to other fields in addition to the medical science field and the ripple effect is thought to be bigger in other science field too.     

An innovative method to measure skin pigmentation

Background/purpose: It is crucial to establish an accurate method for measuring skin pigmentation in cosmetic science and clinical dermatology. Here, we report a non-invasive precise method for measuring skin melanin content.
Methods: In order to determine the concentrations of melanin and hemoglobin in skin, we used the spectrum resolution (SR) method. In brief, the absorption spectrum of the skin was calculated from the reflection spectrum using a spectrophotometer. The concentrations of melanin and hemoglobin were then determined using a multiple regression analysis, assuming that the absorption spectrum of the skin is expressed as a linear summation of the absorptions of melanin and hemoglobin according to the Lambert–Beer law. The skin changes in the volar forearm, which had been irradiated by ultraviolet rays (UV), were observed daily by the SR method.
Results: A multiple regression analysis with an absorption spectrum of 500–700 nm was performed. The multiple correlation coefficient was 0.993, resulting in a satisfactory precise estimate of the concentrations of melanin. After UV irradiation, the concentration of melanin monitored by the SR method increased until 8 days and decreased gradually afterwards.
Conclusions: The SR method allows the evaluation of the changes of epidermal melanin induced by UV irradiation.     

Lichtschutz durch Rotwein?

Background: There is increasing evidence that polyphenols, antioxidants from plants such as green tea or grapes, may impair the UV‐induced erythema reaction as well as carcinogenesis and metastasis of melanoma and epithelial skin cancer. The UVB‐protective potential of wine polyphenols has not been studied so far in humans. Patients and Methods: We tested the influence of local and systemic application of three red wines on the minimal erythema dose (MED) after UVB exposure in 15 healthy male physicians. Baseline MED were determined in all subjects. Irradiation was carried out prior to and immediately following 20 minutes of occlusive application of red wine as well as 12 % alcohol to the back. The systemic effect was tested by ultraviolet irradiation immediately prior to oral intake, Results: There were no topical effects. Wine A also provided no protection sys‐temically. Drinking wine B has led to an almost significant rise of MED, while wine C, which had the highest polyphenol content, produced a statistically significant higher MED (p = 0.031). Conclusions: “Wine baths” will not have sun protective properties. A significant rise of the MED following oral intake of the wine with the highest polyphenol content might be due to these substances. Further research is needed to clarify the role of polyphenol content, dose and duration of wine consumption.     

Population‐based study on the seroprevalence of parvovirus B19 in Amsterdam

A study was undertaken to estimate the seroprevalence of parvovirus B19 infection in the general adult population of Amsterdam, The Netherlands. To our knowledge this is the first study testing parvovirus B19 in a random sample of the Dutch adult population. The study was a cross‐sectional survey, and the study sample was stratified by age and ethnicity, with deliberate oversampling of minority ethnic groups. Serum samples obtained from 1,323 residents in 2004 were tested for antibodies to parvovirus B19. Basic demographic data (gender, age, country of birth, and number of children) were also available. Sixty‐two percent of the participants were seropositive; corrected for the oversampling the estimated prevalence in the Amsterdam adult population was 61%. No specific predictors or risk groups for seropositivity were identified. In our urban adult study population no positive correlation with increasing neither age, nor significant differences between age groups were found. These results imply that almost 40% of the adult Amsterdam population is susceptible to infection. J. Med. Virol. 81:1305–1309, 2009. © 2009 Wiley‐Liss, Inc.