Eosinophilic pustular folliculitis following autologous peripheral blood stem-cell transplantation

We describe a case of eosinophilic pustular folliculitis (EPF) occurring after autologous peripheral blood stem-cell transplantation for non-Hodgkin's lymphoma and successfully treated with oral and topical indomethacin. Including ours, the reported cases of EPF with HIV-negative hematological disease have shown clinical features similar to those of HIV-associated EPF, however the prognosis is better than that for HIV-associated EPF, which usually shows a persistent course. EPF with HIV-negative hematological disease can be classified as a unique group in EPF.     

Proctocolitis in breast fed infants: a contribution to differential diagnosis of haematochezia in early childhood

Dietary protein induced proctocolitis in exclusively breast fed infants is rarely taken into consideration as a cause of rectal bleeding or blood streaked stool in the neonatal period and early infancy. Eleven babies are presented in whom it is believed that bleeding through the rectum was due to proctocolitis as a result of allergy triggered by cows' milk protein transferred to the infants via the breast milk. Colonoscopy was performed in five infants, revealing benign eosinophilic proctocolitis. Standard treatment was the exclusion of the allergen from the mother's diet. Resolution of visible rectal bleeding took place within 72 to 96 hours after elimination of the offending protein from the mother's diet.     

HE和Giemsa染色在结膜刮片检测嗜酸粒细胞的染色比较

目的：通过HE和Giemsa对嗜酸粒细胞的染色效果比较，寻找最佳染色方法。方法：对春季结膜炎20例病人进行结膜刮片，并分别作HE和Giemsa染色，最后用光学普通显微镜观察。结果：在显微镜下，Giemsa染色的嗜酸粒细胞比HE染色的嗜酸粒细胞清晰。结论：实验表明，检测嗜酸粒细胞，采用Giemsa染色，可获得满意的染色效果。     

The usefulness of<Superscript>99m</Superscript>Tc-hexamethylpropyleneamineoxime white blood cell scintigraphy in a patient with eosinophilic gastroenteritis

White blood cell (WBC)^99mTc-hexamethylpropyleneamineoxime (HMPAO) scintigraphy was performed in a patient with eosinophilic gastroenteritis. WBC accumulation was detected in the terminal ileum to descending colon, and pathological studies demonstrated eosinophilic infiltration at the same region.^99mTc-HMPAO-WBC scintigraphy was proved to be a useful tool for the detection of eosinophilic infiltration in eosinophilic gastroenteritis.     

Pulmonary eosinophilic vasculitis in a neonate with congenital chylothorax

We report a case of congenital bilateral chylothorax, complicated by pulmonary eosinophilic vasculitis and transient eosinophilia. Excluding all known forms of eosinophilic pulmonary disease either histologically or clinically, possible mechanisms of its etiology are discussed. Treatment with corticosteroids was successful, and after a prolonged clinical course the patient recovered by age 2 years.     

Cutaneous larva migrans with folliculitis: report of seven cases and review of the literature

Seven patients (four men, three women, mean age 31 years), all returning from the tropics, presented with pruritic folliculitis and creeping eruption. The folliculitis consisted of 20-100 follicular papules and pustules confined to a particular area of the body, mainly the buttocks. The creeping eruption consisted of two to 10 serpiginous or linear burrows 1-5 cm long located either in the same area or in a different area from the folliculitis. Five patients were cured with one to three courses of ivermectin (one course in two cases, two courses in two cases and three courses in one case) and two patients were cured with a 3-day regimen of albendazole. Folliculitis should be added to the dermatological manifestations of cutaneous larva migrans. Treatment is more difficult than in classical forms of cutaneous larva migrans.     

Histopathological and clinical evaluation of chronic spontaneous urticaria patients with neutrophilic and non-neutrophilic cutaneous infiltrate

Background

Chronic urticaria has an expressive prevalence in general population, especially in adults, and is defined by the presence of intermittent hives for six weeks or longer. Our study aims to characterize the histological patterns of chronic spontaneous urticaria, based on the inflammatory cell infiltrate, and correlate them to laboratory exams.

嗜酸性肉芽肿性多血管炎患者的临床特征合并感染情况及预后

目的 分析嗜酸性肉芽肿性多血管炎（EGPA）患者的临床特征、治疗过程中合并感染情况及预后。方法 回顾性分析中南大学湘雅医院2010年1月—2019年4月新诊断为EGPA患者的基本资料、临床病理数据,实验室检查、治疗及预后。根据抗中性粒细胞胞质抗体（ANCA）分为阳性和阴性组,以及治疗过程中患者感染发生状况分为感染组和未感染组,比较两组之间的差异。对EGPA患者进行随访,评估患者治疗反应和生存状况。结果 25例患者中临床表现为过敏性鼻炎和哮喘共12例（48.0%）,发热和（或）肌肉痛15例（60.0%）,神经系统受累17例（68.0%）,肾脏受累17例（68.0%）。8例（32.0%）患者ANCA阳性,ANCA阳性组患者发热及肌痛受累率较高,但两组差异无统计学意义（P>0.05）。有15例患者发生感染,以肺部受累最为常见（11例）,其中5例肺部感染患者痰培养检出病原体,以细菌多见。与未感染组患者相比,感染组患者确诊EGPA时血浆球蛋白水平较高,差异有统计学意义（P<0.05）。25例EGPA患者中1例未接受免疫抑制剂治疗,1例患者接受单纯免疫抑制剂治疗,7例患者接受单纯糖皮质激素治疗,16例（64%）患者接受糖皮质激素联合免疫抑制剂治疗,其中3例患者同时行血浆置换治疗,1例患者同时予以丙种球蛋白冲击治疗。随访过程中10例失访,余15例患者中位随访时间为35（9~70.5）个月,截至最后一次随访时均存活,6例（24.0%）仍有哮喘症状,12例（48.0%）仍需口服糖皮质激素治疗。结论 EGPA临床表现复杂多样,可累及全身多个器官系统,治疗过程中感染发生率高,病变部位以肺部最为常见,病原体以细菌为主。