中西医结合治疗髌骨骨折115例

我院自2000～2006年共收治髌骨骨折患者115例,取得了较好的疗效. 1 一般资料 本组115例,因摔倒、膝跪地32例,车祸外伤者59例,工地损伤24例.男71例,女44例,年龄最小的20岁,最大78岁.诊断标准:有明显的外伤史,局部肿胀、疼痛,膝关节不能自主伸直,不能站立.皮下瘀血,关节内可有瘀血,膝关节前面及两侧明显肿胀.不能直腿抬高或抬腿时剧痛.有错位时可以摸到和看到骨折裂隙,并有明显压痛.不可作被动屈膝检查,以免加重骨折移位.X线检查,确诊为髌骨骨折.保守治疗30例,手术治疗85例.     

甲巯咪唑乳膏透皮吸收的体内动力学

目的:研究甲巯咪唑乳膏经皮给药体内动力学及血清药物含量测定。方法:兔颈前甲状腺局部经皮给药,以高效液相色谱法测定血清中甲巯咪唑浓度,以3P87药动学软件计算药物体内动力学参数。结果:药时曲线符合一室模型,药物吸收速率常数(Ka)为2.590h-1;消除半衰期(T1/2β)为2.258h;峰浓度(Cmax)为1.480μg·ml-1;达峰时间(Tmax)为0.934h;曲线下积分面积(AUC)为6.230μg·ml-1·h。结论:甲巯咪唑乳膏局部给药有良好的透皮吸收性。     

退翳眼膏治疗角膜瘢痕的实验研究

角膜炎,角膜溃疡或角膜外伤愈合后的瘢痕,影响视力,甚至致盲。笔者采用退翳眼膏治疗角膜瘢痕,有效率８８．４１％,并进行动物实验,结果显示：不同浓度的退翳眼膏和消朦眼膏１,对角膜瘢痕的消退均有明显的疗效。２０％退翳眼膏优于消朦眼膏１,并与临床观察一致     

钙泊三醇倍他米松乳膏、卡泊三醇软膏序贯治疗银屑病的效果

探讨予以银屑病患者钙泊三醇倍他米松乳膏以及卡泊三醇软膏序贯治疗的效果。方法 选 取2022年4月-2023年4月容城县人民医院收治的80例银屑病患者为研究对象，将其随机分为对照组和研究 组，每组40例。对照组使用卡泊三醇软膏治疗，研究组使用钙泊三醇倍他米松乳膏联合卡泊三醇软膏序贯 治疗，比较两组临床疗效、皮损程度和不良反应发生情况。结果 研究组总有效率为92.50%，高于对照组 的72.50%（P ＜0.05）；两组治疗后银屑病面积和严重程度指数（PASI）评分低于治疗前，且研究组低于对 照组（P ＜0.05）；研究组不良反应发生率为5.00%，低于对照组的25.00%（P ＜0.05）。结论 银屑病患者 治疗过程中，联合应用钙泊三醇倍他米松乳膏与卡泊三醇软膏序贯治疗，可减轻患者皮损程度，促进临床 疗效提升，安全性高。     

泪道探通术联合四环素眼膏填充治疗泪道阻塞的疗效观察

目的观察泪道探通术联合四环素眼膏填充治疗泪道阻塞的临床疗效。方法选取门诊110例泪道阻塞患者作为治疗组,用泪道探通术联合四环素眼膏填充术治疗;90例泪道阻塞门诊病人作为对照组,采用传统泪道探通术后常规冲洗。结果治疗组治愈率达81.8%,总有效率为93.2%,与对照组相比,差异均具有显著性(P<0.05),且在治疗过程中没有出现明显的不良反应。结论采用泪道探通术联合四环素眼膏填充术治疗泪道阻塞操作简单、效果良好、并发症少,医疗费用低廉,不失为一种简便易行,经济实用的方法,值得基层医院临床推广。     

中药烧伤膏I号联合削痂治疗小面积Ⅲ度烧伤的疗效观察

目的　探讨中药烧伤膏1号联合削痂治疗小面积Ⅲ度烧的疗效。方法　常规清创和削、切痂后,局部贴敷中药烧伤膏Ⅰ号,创面溶脱,液化前隔日换药,以后每日换药直至创面愈合。结果　全部病例均未植皮,创面愈合良好,愈合时间25-48d,82％(59/72)病例在5周内治愈。结论　该法不需植皮,愈合快,瘢痕轻,不失为是治疗小面积深度烧伤的有效方法之一。     

Topical calcitriol – studies on local tolerance and systemic safety

Calcitriol 3 μg g⁻¹ ointment (Silkis ointment®, Galderma Laboratories) is a new treatment for psoriasis. Calcitriol is the biologically active metabolite of vitamin D₃. It induces keratinocyte differentiation, inhibits keratinocyte, T-cell and fibroblast proliferation, and inhibits the production of some inflammatory mediators, all contributors to the pathogenesis of psoriasis. Preclinical studies have shown an effect of topical calcitriol on calcium homeostasis at doses higher than those in clinical use. No adverse local events were observed when calcitriol was applied to animal skin. Phase I clinical studies confirmed that calcitriol 3 μg g⁻¹ ointment is well tolerated in humans. These studies have demonstrated that at the minimal effective concentration of 3 μg g⁻¹, calcitriol ointment has no discernible photosensitizing or phototoxic potential and no skin irritant or allergic potential in healthy volunteers. Its low systemic absorption through human skin is unlikely to significantly affect calcium homeostasis. This paper summarizes the findings of the preclinical and early clinical studies that provided the foundation of the later Phase II and III clinical trials on efficacy and safety with topical calcitriol 3 μg g⁻¹ ointment for the treatment of plaque psoriasis.     

中药穴位贴敷抗小鼠艾氏腹水癌作用的实验研究

进行中药抗癌腹水膏穴位贴敷抗小鼠艾氏腹水癌作用的实验研究，结果显示：该疗法能明显改善荷瘤小鼠的一般状况，抑制荷瘤小鼠的腹水量，不同程度地延长荷瘤小鼠的生存期，并使荷瘤小鼠腹水癌细胞数量减少，免疫功能增强。     

Evaluation of the healing activity of hydrocotyle tincture in the treatment of wounds

The object of this study was to evaluate the healing activity of Cothyline^TM, a new formulation comprising asiaticoside as the main ingredient in combination with antiseptic adjuvants. The study has two parts: (1) a clinical phase involving the observation of patients afflicted with soiled wounds and chronic or recurrent atony which was resistant to the usual treatment, and (2) an experimental phase in which the healing action of Cothyline was evaluated by light and electron microscopic observation of the morphological changes that occurred in scarified guinea pig skin. Treatment of patients with Cothyline completely healed (64%) or improved (16%) the lesions under study. In the animal study, it was shown that changes occurred in the shape and size of the keratohyaline granules, a phenomenon observed during accelerated healing. To the best of our knowledge, this is the first time that the healing action of Cothyline has been demonstrated in an objective and controlled manner. Cothyline has the unique advantage of simultaneously acting as an antiseptic and a cicatrizant; moreover, it affects all four phases of healing. This drug constitutes a new and advantageous approach in the treatment of wounds.