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31.
32.
Virulence of Candida albicans mutants 总被引:5,自引:0,他引:5
Annemarie Polak 《Mycoses》1992,35(1-2):9-16
Mutant strains of the fungal pathogen Candida albicans blocked in pyrimidine transport and salvage metabolism were tested for virulence in various animal models. The growth rate, germination and proteolytic enzyme production did not correlate with the virulence of the strains. However, a defect in the uridine transport system significantly decreased virulence in murine candidosis, although it had no effect in vaginal candidosis or in a Candida cyst model. It remains unclear whether this is due to the differing host defence mechanisms involved in systemic and superficial mycoses, or to the different requirements of the fungal systems for adherence and tissue invasion in the two types of infection. 相似文献
33.
刺梨汁对慢性氟中毒的影响及机理研究 总被引:1,自引:0,他引:1
用高氟饲料喂养大鼠6个月,复制出慢性氟中毒模型,再自由饮用刺梨汁3个月,探讨刺梨汁对慢性氟中毒的影响及机理。结果表明:刺梨汁可明显改善氟中毒的一般状况,对已形成的氟斑牙影响不大,但可促进尿氟排泄,降低血清和骨氟含量及尿羟脯氦酸含量,提高血清中维生素C、维生素E和血清、肝、肾GSH含量,增强血、肝、肾GSH-Px和SOD活性,降低血清、肝和肾LPO含量,降低尿γ-GT和血清GPT活性及肝TG含量,提示:刺梨汁具有明显桔抗慢性氟中毒作用,其机理可能是通过促进尿氟排泄和抗氧化作用。 相似文献
34.
Abstract The study of animal lectins and glycoconjugates has become an important area of research in biomedical sciences, as these molecules are believed to play important roles in a variety of biological processes. This report describes a study of the expression of an animal lectin, IgE-binding protein (?BP), also known as Mac-2 and CBP35, in human skin. We have analyzed cultured human keratinocytes as well as normal human skin and a number of epidermal neoplasms, by immunoblotting. immuno-fluorescence and immunohistochemistry. We showed that ?BP is expressed in human keratinocytes, hair follicles, sebaceous and sweat glands. We found that cBP expression retains in various epidermal neoplasms, including basal cell carcinoma, squamous cell carcinoma and keratoacan-thoma, although the level of expression appears to be reduced as compared to normal epidermis. The immunohistochemical analysis also suggests that the level of ?BP expression appears to be dependent on the degree of cellular differentiation of keratinocytes. 相似文献
35.
患实验性牙龈炎的大鼠牙龈(6例)经脉冲掺钕钇铝柘榴石激光(Nd:YAG激光)照射后进行光镜及超微结构观察。目的在于了解低能量Nd:YAG激光照射对牙龈炎症的治疗作用。炎症牙龈经输出能量为1.5W,脉冲数为20PPS的激光照射后与对照组相比较,形态学上有如下变化:上皮细胞无变性;牙龈上皮层数较炎症时减少;上皮下炎细胞浸润明显减少;上皮细胞间隙变小;上皮下结缔组织内产生大量的排列致密的胶原纤维。结果提 相似文献
36.
Ni Yan-xia 《中国结合医学杂志》1995,(1)
TherapeuticEffectofBerberineon60PatientswithNon-InsulinDependentDiabetesMellitusandExperimentalResearchNiYan-xia(倪艳霞);LiuAn-q... 相似文献
37.
完全胸腔镜下心内直视手术的实验研究 总被引:1,自引:0,他引:1
目的 探索完全胸腔镜下心内直视手术可行性手术过程中的可能风险。方法 选取 6 0支杂种成年狗 ,雌雄不拘 ,按手术前后顺序分为A、B、C三组 ,每组 2 0例 ,行完全胸腔镜下心内直视手术。记录每例手术时间、术中出现的意外损伤 ,对各组结果进行比较。结果 手术平均时间分别为 :A组 (5 6± 1 2 )h ,B组 (3 4± 0 8)h ,C组 (2 1± 0 3)h ;手术失败三组分别为 3、0、0例 ;三组实验动物意外损伤发生率 ,A组明显高于B、C组 (P <0 0 5和 0 0 1) ,分别为 2 4、8、1处。结论 经过一定时间技能训练 ,行完全胸腔镜下心内直视手术是可行的 相似文献
38.
39.
S. Irani C. Mahler L. Goetzmann E.W. Russi A. Boehler 《American journal of transplantation》2006,6(2):404-411
Since lung transplant recipients are susceptible to infections and inhaled pollution, many centers warn against pets. However, data supporting this recommendation are lacking. Our program is less restrictive regarding pets. This study, for the first time, investigates the association of pets with physiological and psychological parameters in these patients. A questionnaire concerning pets was sent to 104 lung transplant recipients. Lung function tests, levels of exhaled nitric oxide (FE(NO)), need for antibiotic treatments and hospitalizations, creatinine clearance, body mass index (BMI) and demographic data were assessed. Additionally, the questionnaire of life satisfaction (FLZ), a question on summarized life satisfaction (LS), the life orientation test (LOT), the hospital anxiety depression scale (HADS) and the social support questionnaire (F-SozU) were assessed. Response rate was 86%. Fifty-two percent defined themselves as pet owners, whereas 48% did not. The two groups did not differ in demographic or physiological data. Significant differences in FLZ (79/65, p = 0.04), in LS (4.3/3.9, p = 0.01), LOT (32/29, p = 0.006) and F-SozU (4.5/4.2, p = 0.04) were found in favor of pet owners. In lung transplant recipients keeping pets the frequency of somatic complications is not higher compared to lung transplant recipients without pets. After lung transplantation, pets are associated with a better quality of life. 相似文献
40.