中下面部线雕联合局部注射填充对皮肤状态及不良反应的影响

目的 探究在面部年轻化治疗中采用中下面部线雕联合局部注射填充的效果及对皮肤状态的影响。 方法 选取2021年1月-2024年1月于观山湖科珑小可美容诊所美容皮肤科行面部年轻化治疗的60例患者, 随机分为对照组和观察组,每组30例。对照组采用局部注射填充治疗,观察组采用中下面部线雕联合局 部注射填充治疗,比较两组皮肤状态、心理状态、生活质量及不良反应发生情况。结果 观察组术后皮 肤水分、弹性评分高于对照组,油脂、暗斑评分低于对照组（P ＜0.05）;观察组术后SAS、SDS评分均 低于对照组（P ＜0.05）;观察组术后生活质量各维度评分均高于对照组（P ＜0.05）;观察组不良反应发 生率为6.67%,低于对照组的30.00%（P＜0.05）。结论 中下面部线雕联合局部注射填充在面部年轻化中的 应用效果确切,抗衰效果及美学效果良好,可有效改善皮肤质地,减少皱纹,且治疗后不良反应较少,安 全性较高,有利于改善患者的心理状态及生活质量,值得临床应用。     

应用梯形皮瓣松解烧伤后疤痕挛缩

应用梯形皮瓣松解烧伤后疤痕挛缩是一种新手术方法,本手术方法也可应用在外伤后疤痕挛缩。适宜于身体多个部位。     

106例老年皮肤病变活检分析

本文报告106例老年皮肤病患者皮肤活检结果,发现皮肤肿瘤的患病率居首位,占41.56%,良、恶性肿瘤各占一半。结果提示:凡老年皮肤病患者均应警惕癌肿的发生。     

维持性血液透析患者皮肤并发症的临床特点和护理对策

目的分析维持性血液透析患者皮肤并发症的临床特点,研究对应的护理方法。方法将该研究中的维持性血液透析且并发皮肤病的100例患者随机均分为护理组和对照组,对照组患者维持常规血液透析,护理组患者采用血液灌流联合血液透析法,同时,加强对患者的护理和健康指导,以2个月为一个观察期,对护理结果进行评判、统计疗效。结果护理组患者的皮肤病症状得到有效缓解,对照组患者的皮肤并发症情况没有明显改善。结论恰当的治疗护理、心理护理和健康教育等措施,对缓解维持性血液透析患者的皮肤并发症有显著功效。     

硬膜外麻醉时皮肤电传导变化的临床观察

目的探讨硬膜外麻醉时皮肤电传导(SC)基态值和反应波的变化。方法选择25例ASAⅠ或Ⅱ级下肢手术患者。记录硬膜外给药前(T0)、给予1%利多卡因5ml后5min(T1)、给予0.75%罗哌卡因10ml后5、10、15、25和45min(T2～T6)时的SC基态值(SC0)、针刺非阻滞区SC反应波的振幅差值(SC1)和痛觉阻滞区的SC反应波的振幅差值(SC2)。使用ROC曲线、逻辑回归分析评价SC反应波的振幅差值区分痛觉阻滞区和非阻滞区的准确性。结果与T0时比较,T3～T6时的SC0及SC1的均值明显降低(P<0.05),T1～T6时SC2明显低于SC1(P<0.05)。SC反应波的振幅差值ROC曲线下面积为0.928±0.017(P<0.01),特异性与敏感性分别为78%和88%,预测整体准确率84%。结论 SC基态值及反应波振幅差值的变化对定位硬膜外麻醉平面有一定指导作用。     

A case of cutaneous polyarteritis nodosa with elevated serum interleukin-6 levels complicated by leg arterial stenosis and destructive arthropathy of the left ankle

Abstract

We report a case of a 60-year-old female with cutaneous polyarteritis nodosa (CPN) of the left ankle, accompanied by elevated serum interleukin (IL)-6 levels. Computed tomographic angiography revealed severe narrowing of medium-sized arteries in her left leg. Destructive arthropathy in the left ankle was identified by X-ray and magnetic resonance imaging. This is the first Japanese case of severe CPN complicated by destructive arthropathy. Quantification of serum IL-6 might be useful in diagnosis and evaluation of CPN.     

Skin tumorigenic potential of benzanthrone: Prevention by ascorbic acid

Benzanthrone (BA) exposed occupational workers have been found to exhibit toxicological manifestations in the skin, thus it is quite likely that long term exposure may lead to skin tumorigenicity. Thus, attempts were made to elucidate the tumor initiating and promoting potentials of pure (PBA) and commercial benzanthrone (CBA). Additionally, the preventive role of ascorbic acid (AsA) was also assessed. PBA showed tumor initiating activity while CBA demonstrated tumor initiating as well as promoting activities in two-stage mouse skin tumor protocol. Further, prior treatment of AsA to PBA and CBA followed by twice weekly application of 12-o-tetradecanoyl phorbal myristate acetate (TPA) resulted into delayed onset of tumor formation and similarly single application of 7,12-dimethylbenz [α] anthracene (DMBA) followed by twice weekly application of AsA and CBA showed an increase in the latency period. Thus, AsA showed a protective effect against CBA promoted skin tumor. Furthermore, the topical application of CBA significantly increased the levels of xenobiotic enzymes. The animals topically treated with AsA along with topical application of CBA, restored all the impairment observed in enzyme activities. Thus, this study suggested that AsA can be useful in preventing PBA and CBA induced skin tumorigenicity.     

Cultured composite autografts as coverage for an extensive body surface area burn: case report and review of the technology

Cultured epithelial autografts (CEA) have been used as an adjunct in the surgical management of extensive thermal burns. Unfortunately, the lack of a dermal matrix makes CEA susceptible to infection, shearing forces and limits their incorporation into the burn wound. A cultured composite autograft (CCA) has been developed in which autologous keratinocytes and fibroblasts are surgically harvested from the burn patient's normal skin. These components are proliferated and then combined to form an epidermal and dermal matrix, grown to confluence then applied.

Standard wound coverage techniques as well as CCA technology were utilized for successful wound closure in a 12 yr-old female with an 81% third degree burn. After fascial excision and allograft coverage, autografts were placed on her posterior burns and then 7500 cm² of CCA was placed onto her anterior thorax, abdomen and lower extremities. Sixty percent of the burn was covered with CCA resulting in a success rate of 40%. No evidence of infection was noted, even in areas where CCA failed, although in those areas random epithelialization appeared to occur which then seemed to facilitate autograft placement. Early debridement and allografting followed by conventional autografts and CCA placement may provide an effective skin coverage strategy in patients with extensive deep burns.     

皮肤伸展术在创伤修复重建外科中的应用

目的观察验证皮肤伸展器的可行性及临床应用效果。方法采用周黎安自行设计的针爪结合的皮肤伸展器,在皮肤缺损创缘行皮肤伸展术,治疗烧（创）伤肉芽创面、供皮瓣创面及肿瘤切除后的缺损共３４例。结果该装置使用时间为１５～７２０分钟,可分别在术前、术中及术后三个不同阶段使用。随访１６例,时间为６～１２个月,效果均满意。结论此种针爪结合的皮肤伸展器对创伤及其它原因造成的皮肤软组织缺损的创面闭合有积极意义,是一种行之有效的治疗方法。     

皮肤与骨骼复合缺损的修复

目的 探讨显微外科修复肢体骨与皮肤复合缺损的技术和效果。方法 39例肢体骨与皮肤复合缺损患者接受显微外科手术修复:游离移植背阔肌肌皮瓣,而后髂骨植骨4例,移植髂骨皮瓣7例,移植腓骨皮瓣6例,组合移植背阔肌肌皮瓣与游离腓骨20例,组合移植双侧背阔肌肌皮瓣与游离腓骨2例。结果 移植组织完全成活30例,9例移植的(肌)皮瓣远端皮肤发生局部浅表坏死,经换药后愈合。移植骨术后12～18周与宿主骨牢固连接。平均随访3年6个月,修复肢体均恢复有用功能。14例12岁以下儿童,修复后下肢生长正常,未发生肢体不等长现象。结论 严格手术指征,准确操作,酌情选择不同皮瓣与骨复合组织移植的显微外科修复是治疗骨与皮肤缺损的有效手段。