睾丸病变的CT诊断

目的：评价ＣＴ对睾丸病变的诊断和鉴别诊断价值。方法：ＣＴ机为ＳＣＴ－４８００ＴＦ及部份ＧＥ８８００机，对１４例睾丸病变行ＣＴ扫描，层厚、层距各２ｍｍ，平扫加６０％泛影葡胺５０ｍｌ静脉团注、快扫。结果：１４例都经手术病理证实、其中４例外伤、３例肉芽肿性炎症、３例精原细胞瘤、２例睾丸结核、２例隐睾（１例并发精原细胞瘤），ＣＴ都存在具有诊断价值的征象。结论：通过仔细观察ＣＴ上睾丸包膜、实质及阴囊隔的形态改变、以及与周围组织结构关系，并密切结合临床综合分析，有助于提高睾丸病变的诊断和鉴别诊断的准确性，同时技术上要求薄层加快速增强扫描     

Derivation of the Genital Injury Severity Scale (GISS): A concise instrument for description and measurement of external female genital injury after sexual intercourse

IntroductionInconsistencies abound in the current forensic literature regarding the definition, and as a result, the significance of female genital injury after sexual intercourse. These definitions are based on variables related to the anatomic locations that are examined, the actual physical findings types, and the methods used to detect the findings.PurposeTo derive and perform initial clinimetric analyses on a simple instrument that defines, and based on severity, quantifies external genital injury after sexual intercourse. The scale utilizes standard injury definitions and a standardized examination method.MethodsAfter empirical investigation, it was determined that the application of the tool would require the use of magnification and toluidine blue in order to have the sensitivity to detect the majority of injuries that occur after sexual intercourse. Separate matrices were constructed based on anatomic locations and injury types from data collected from sexual assault genital injury examination forms. Principal Components Analyses were applied. A clinical model was constructed from the resultant variables, utilizing operational definitions and forming a template for the instrument.ResultsA twelve-factor instrument measuring five variables along five “types” of severity and two “classes” of severity ensued. The resultant instrument was tested for internal consistency and differential validity. Very good internal consistency was attained (Cronbach's Coefficient α = 0.8). In a pilot study, the scale was able to distinguish a cohort of sexual assault patients from one of consensual intercourse subjects based on type and class of injury (p < 0.0001).ConclusionThe findings presented demonstrate that while employing a standardized examination method, the Genital Injury Severity Scale has utility in defining and measuring external genital injury after sexual intercourse.     

电针夹脊穴配合放血拔罐治疗带状疱疹疗效观察

目的:比较电针夹脊穴配合放血拔罐法与西药治疗带状疱疹的疗效差异.方法:将53例患者随机分为观察组(31例)、对照组(22例).观察组采用电针夹脊穴配合疱疹局部梅花针刺血加拔火罐治疗,每天1次;对照组采用口服盐酸伐昔洛韦、吲哚美辛、维生素B1、维生素B_(12).结果:观察组显愈率为96.8%,优于对照组的81.8%(P<0.05);在疼痛、瘙痒、烧灼感及睡眠临床症状改善方面,观察组优于对照组(均P<0.01).结论:电针夹脊穴配合放血拔罐是治疗带状疱疹的有效方法,疗效优于常规西药治疗.     

播散性带状疱疹后肉芽肿性炎型Wolf同位反应一例

【摘要】 患者男,65岁,因右面部红肿20 d,背部、双上肢散在丘疹10 d入院。发病前20 d曾因播散性带状疱疹住院治疗。确诊慢性淋巴细胞白血病3年。皮肤科检查：右面部眼睑以下区域、耳廓及外耳道弥漫性暗红色肿胀性斑块,触之有浸润感,原带状疱疹愈合后遗留散在褐色结痂,其间可见散在凹陷性瘢痕;颈后、背部及双上肢可见散在浸润性淡红色丘疹,绿豆至黄豆大小,表面较光滑。面部皮损组织病理检查：真皮全层及皮下脂肪层可见上皮样细胞和淋巴细胞呈结节状浸润,并含较多多核巨细胞;免疫组化：CD68、CD20、CD79a、CD3、CD2、CD10、CD5、Bcl-2阳性、Ki-67散在阳性,CD23、细胞周期蛋白D1、Bcl-6、多发性骨髓瘤癌基因1、CD21、CD35、髓过氧化物酶均阴性。诊断：播散性带状疱疹后肉芽肿性炎型Wolf同位反应。治疗：静脉滴注甲泼尼龙40 mg/d,皮损逐渐好转消退,随访4年未复发。     

阿昔洛韦联合阴道用乳杆菌胶囊治疗女性复发性生殖器疱疹的疗效分析

目的 探讨阿昔洛韦联合阴道用乳杆菌胶囊治疗单纯疱疹病毒(HSV)感染引起的女性复发性生殖器疱疹患者的疗效和安全性.方法 选取2016年10月至2018年10月四川省广安市人民医院诊治的220例复发性生殖器疱疹女性患者作为研究对象.按照随机数字表法分为观察组(n=110)和对照组(n=110).观察组口服阿昔洛韦片联合阴...     

肺癌术后放化疗并发泛发性带状疱疹1例

报告１例６０岁男性患者,３周前右季肋区出现疼痛性水疱,２周前皮损全身泛发,伴高热。患者１年前行右肺癌根治术,术后一直接受Ｘ线放射治疗和化疗,此次皮损播散发生于例行化疗的第２ｄ,提示发病与肿瘤放化疗造成的免疫抑制相关。治疗应及时给予大剂量无环鸟苷和支持疗法。     

The role of polymorphonuclear leukocyte infiltration in herpes simplex virus infection of murine skin

Abstract We undertook the present study to investigate the role of polymorphonuclear leukocytes (PMN) in defending skin against herpes simplex virus (HSV) infection. For this purpose, we established a mouse model of cutaneous HSV infection. The hind limb footpad skin of 4-week-old ICR mice was abraded linearly once with a feather edge file and infected with various strains of HSV with different virulence. In uninfected control mice, PMN appeared at the abraded skin lesion within 24 h, and were eliminated from the epidermis after 3 days. Mice inducted with a highly virulent strain of HSV demonstrated wide and severe erythematous lesions of the footpad skin and histologically, virus antigen-positive ballooning degenerated keratinocytes were observed. However, in infections with attenuated strains of HSV, the epidermis was regenerated and a viral antigen was discharged within 5 days, together with any infiltrated PMN. Macrophages and NK cells numbered less than PMN. In mice treated with anti-PMN antiserum before HSV infection, PMN infiltration was significantly suppressed 1 day after infection, and these animals developed a severe cutaneous disease even if infected with an attenuated virus. These results indicate the importance of PMN in the control of HSV cutaneous infections, especially in the primary infectious phase. Received: 17 April 1998 / Received after revision: 3 September 1998 / Accepted: 11 September 1998     

In vitro studies on the human cellular immune response to commercially available herpes simplex antigens

Summary Patients with recurrent herpes labialis and genitalis as well as normal controls were tested for the in vitro responsiveness of their lymphocytes to mitogens, to several herpes antigens and to carrier medium alone (containing chorioallantois membrane antigens). No statistically significant differences were found in the results with the direct and indirect migration inhibitory test (MIF) and in studies of the blastogenic response of lymphocytes (LTT) among the three groups. These findings held up when correlations were drawn to severity or course of the disease and suggest that immunological modulation can play at most a minor role in inducing recurrent herpes simplex infections.     

多重PCR检测性传播生殖器溃疡性疾病病原体方法的研究

目的建立多重PCR用于快速检测引起性传播生殖器溃疡性疾病(GUD)常见病原体。方法根据各病原体特异性基因序列,即单纯疱疹病毒I和II型(HSV1和HSV2)的DNA聚合酶基因、梅毒螺旋体47KD膜蛋白基因、沙眼衣原体的主要外膜蛋白基因(omp1/ompb)及杜克雷嗜血杆菌16SrRNA基因序列,自行设计4对特异寡核苷酸引物,建立同时检测4种病原体DNA的多重PCR。结果各特异性引物仅扩增相应的病原体DNA。其他几种生殖道常见菌及人基因组DNA不被上述引物扩增。检测了51例临床标本,多重PCR检查结果与暗视野显微镜检查梅毒螺旋体和培养法检查HSV结果进行比较,均有较好的一致性。结论多重PCR检测4种引起GUD常见病原体DNA具有较好的特异性,可为GUD患者提供敏感、快速和准确的诊断手段。