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Systemic sarcoidosis revealed by ventricular tachycardia: electrocardiography and MRI correspondence
Latcu DG Duparc A Chabbert V Labarre D Mondoly P Maury P Delay M 《Pacing and clinical electrophysiology : PACE》2007,30(12):1566-1570
We describe a case presenting with ventricular tachycardia as the manifestation leading to the diagnosis of sarcoidosis. The ventricular tachyacardia's origin is correlated with granuloma localization on magnetic resonance imaging. 相似文献
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Pérez-Grueso MJ Repiso A Gómez R Gonzalez C de Artaza T Valle J García A Carrobles JM 《Journal of clinical ultrasound : JCU》2007,35(7):405-408
We report the case of a 74-year-old woman with elevated liver enzyme levels in whom abdominal sonographic examination revealed a diffusely heterogeneous liver parenchyma and multiple hypoechoic subcentimetric splenic nodules. Contrast-enhanced sonography (CEUS) revealed that the splenic focal lesions did not enhance. CT examination revealed a low-density, multinodular pattern both in the liver and in the spleen. Core biopsy of 1 hepatic nodule revealed noncaseating epithelioid cell granuloma, and the patient was diagnosed with systemic sarcoidosis. CEUS has shown to be useful in the diagnosis of focal hepatic lesions, but studies referring to splenic lesions are lacking. 相似文献
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OBJECTIVES: The balance between Th1 and Th2 T cells, classified by virtue of their cytokine production can in an immune response influence the phenotype and progression of several clinical diseases. In this study, we examined the expression of Th1 associated chemokine and cytokine receptors CXCR3, CCR5, and interleukin (IL)-12R, IL-18R, respectively, as well as of the Th2 associated chemokine receptors CCR4 and CXCR4 on CD4+ and CD8+ T cells. SUBJECTS: Eighteen patients with untreated pulmonary sarcoidosis. MATERIALS AND METHODS: We used monoclonal antibodies and flow cytometry to analyse the expression of chemokine receptors CXCR3, CXCR4, CCR4 CCR5 and cytokine receptors IL-12R, IL-18R in combination with anti-CD4 and anti-CD8 mAbs in bronchoalveolar lavage fluid (BAL) and peripheral blood lymphocytes (PBL) from sarcoidosis patients. RESULTS: There were significantly more BAL CD4+ T cells expressing CXCR3, CCR5, IL-12R and IL-18R compared with paired PBL CD4+ T cells. In contrast, the Th2 associated chemokine receptors CXCR4 and CCR4 were expressed by a fewer percentage of BAL CD4+ compared with PBL CD4+ T cells. There was a positive correlation between the percentage of BAL lymphocytes and the number of CXCR3 and CCR5 expressing CD4+ BAL T cells. Also, the number of CD4+ IL-18R+ BAL fluid cells correlated negatively with disease duration. CONCLUSIONS: The lung accumulation of CXCR3, CCR5, IL-12R and IL-18R expressing T cells is in line with previous reports showing elevated levels in the lung of the corresponding ligands in sarcodosis. Blocking such ligands and/or receptors may develop into a future immunomodulatory therapy. 相似文献
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Edgar V. Lerma 《Clinical reviews in bone and mineral metabolism》2004,2(3):209-216
Stones in the genitourinary tract commonly present with abdominal pain, hematuria, and dysuria. In certain cases, however,
the diagnosis is not straightforward because of either the absence of the aforementioned symptoms or the various diseases
that can present in a similar fashion. In those situations, the laboratory tests and ancillary procedures available, in addition
to the actual clinical history and physical examination, are used in combination to establish the appropriate diagnosis. It
must be pointed out that a great deal of knowledge of anatomy, particularly the genitourinary tract, is essential in understanding
such varied clinical presentations.
In this article, various disease entities, such as, polycystic kidney disease, medullary sponge kidney, and situations such
as pregnancy, which are characterized by predispositions to formation of various types stones in the genitourinary tract,
are also presented. 相似文献
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A granulomatous conundrum: Concurrent necrobiosis lipoidica,cutaneous sarcoidosis and erythema nodosum in a nondiabetic patient
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Nishant Valecha Genevieve Bennett Leona Yip 《The Australasian journal of dermatology》2017,58(4):e232-e235
Necrobiosis lipoidica (NL) and cutaneous sarcoidosis are granulomatous disorders with a largely unknown aetiopathogenesis. Evidence of co‐existing NL and sarcoidosis in the same patient may suggest a degree of overlap between these entities through shared granulomatous inflammatory pathways. Occasionally, one condition can mimic the other, making their distinction difficult. We report a novel case of a non‐diabetic woman who presented with concurrent NL, cutaneous sarcoidosis and erythema nodosum. We discuss some of the complexities distinguishing these entities and propose that they may represent different stages of the same granulomatous process linked through yet unknown pathomechanisms. 相似文献