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991.
电针对脑出血大鼠脑组织病理形态学及脑组织含水量和神经损伤积分值的影响 总被引：3，自引：0，他引：3
目的 :观察电针对大鼠脑出血模型的疗效。方法 :选择胶原酶加肝素联合注射法诱导脑出血大鼠模型 ,观察电针不同穴位对其脑组织病理形态学、脑含水量和神经损伤积分值的影响。结果 :电针水沟组 (取水沟、上星穴 )、电针风府组 (取风府、哑门穴 )均可明显改善胶原酶加肝素联合注射法诱导大鼠脑出血模型的脑组织形态学损害和神经行为功能的缺损 ,降低因出血导致的血肿周围组织的水肿 ;且电针水沟组在改善大鼠脑出血模型的脑组织形态学损害和神经行为功能的缺损方面 (72h姿势反射和平衡反射积分值 )优于电针风府组。结论 :电针水沟、上星和电针风府、哑门对大鼠脑出血损伤均有一定程度的保护作用 ,且前者的保护作用优于后者 相似文献
992.
Victoria E. Rey Caballero Manuel Urbaneja LópezJosé L. García Benítez Dahlia Quijada To Ong 《Progresos de Obstetricia y Ginecología》2008
Cerebral venous sinus thrombosis is uncommon. Pregnancy is a major risk factor for the development of this entity. We report the case of a patient with Job’s syndrome and protein C and S deficiency who developed cerebral venous sinus thrombosis and dural fistula at 36 weeks’ gestation. After heparinization, the treatment of choice, pregnancy termination to eliminate the prothrombotic status and embolization of the dural fistula were required to obtain complete remission of the neurological symptoms. 相似文献
993.
994.
995.
Whole-genome analysis of human astrocytic tumors by comparative genomic hybridization 总被引：1，自引：0，他引：1
Maruno M Ninomiya H Ghulam Muhammad AK Hirata M Kato A Yoshimine T 《Brain tumor pathology》2000,17(1):21-27
Frozen sections of 35 astrocytic tumors of various histologic malignancies were analyzed by comparative genomic hybridization
in an attempt to characterize the profile of genetic aberrations. Over 94% of the samples revealed DNA copy number aberrations,
which increased with higher histological malignancy grades, and also involvement of more than one chromosome was seen in 85%
of instances. The aberrations observed were mainly deletions and most frequently incorporated chromosomes 1p, 10, 19q, and
22q. On the other hand, gains or amplifications were detected only in glioblastomas. Additionally, such gains or amplifications
were present in all tumor samples where the initial histopathological diagnosis was glioblastoma and immunohistochemical study
disclosed p53 tumor suppressor protein negative and epidermal growth factor receptor positive immunoreactivity; such glioblastomas
possessing p53 tumor suppressor protein positive and epidermal growth factor receptor negative immunoreactivity seldom displayed
any gain. Thus, glioblastomas exhibiting two different profiles of genetic aberrations were recognized—one with and the other
without any gains/amplifications. We speculate that the former variety is de novo glioblastoma. 相似文献
996.
Camila W. Schaan Felipe V. Cureau Mariana Sbaraini Karen Sparrenberger Harold W. Kohl III Beatriz D. Schaan 《Jornal de pediatria》2019,95(2):155-165
Purpose
To evaluate the prevalence of excessive screen-based behaviors among Brazilian adolescents through a systematic review with meta-analysis.Data source
Systematic review and meta-analysis were recorded in the International Prospective Register of Ongoing Systematic Reviews (PROSPERO-CRD 2017 CRD42017074432). This review included observational studies (cohort or cross-sectional) that evaluated the prevalence of excessive screen time (i.e. combinations involving different screen-based behaviors) or TV viewing (≥2 h/day or >2 h/day in front of screen) through indirect or direct methods in adolescents aged between 10 and 19 years. The research strategy included the following databases: MEDLINE, LILACS, SciELO and ADOLEC. The search strategy included terms for “screen time”, “Brazil”, and “prevalence”. Random effect models were used to estimate the prevalence of excessive screen time in different categories.Data summary
Twenty-eight out of 775 studies identified in the search met the inclusion criteria. The prevalence of excessive screen time and TV viewing was 70.9% (95% CI: 65.5–76.1) and 58.8% (95% CI: 49.4–68.0), respectively. There was no difference between sexes in both analyses. The majority of studies included showed a low risk of bias.Conclusions
The prevalence of excessive screen time and TV viewing was high among Brazilian adolescents. Intervention are needed to reduce the excessive screen time among adolescents. 相似文献997.
Fermín García-Muñoz Rodrigo Loida García Cruz Gloria Galán Henríquez Lourdes Urquía Martí Sonia Rivero Rodríguez Alfredo García-Alix Josep Figueras Aloy 《Jornal de pediatria》2019,95(1):41-47
Objective
To know the distribution of births of very low birth weight infants by day of the week, and whether this distribution affects the morbidity and mortality in this group of patients.Methods
This was a retrospective analysis of data collected prospectively in the Spanish SEN1500 network (2002–2011). Outborn infants, patients with major congenital anomalies, and those who died in the delivery room were excluded. Births were grouped into “weekdays” and “weekends.” A multivariate logistic regression analysis was conducted to evaluate the independent effect of the birth moment on outcomes, and Cox regression for survival.Results
Out of a total of 27,205 very low birth weight infants born at and/or admitted to the participating centers, 22,961 (84.4%) met inclusion criteria. A reduction of 24% in the number of births was observed during the “weekends” compared with “weekdays”. In the raw analysis, patients born on weekends exhibited higher morbidity and mortality (mortality rate: 14.2% vs. 16.5%, p < 0.001), but differences were no longer significant after adjusting for confounding factors.Conclusions
The present results suggest that current care practices reduce the proportion of births during the weekends and tend to cluster some high-risk births during this period, increasing crude morbidity and mortality. However, after adjusting for confounding factors, the differences disappear, suggesting that overall care coverage in these centers is appropriate. 相似文献998.
999.
M. Diéguez Felechosa C. Sánchez Ragnarsson M. Riestra Fernández P. Suárez Gil E. Delgado Alvarez E. Menéndez Torre 《Clínica e investigación en ginecología y obstetricia》2019,46(1):9-14
Objective
To estimate the effectiveness of selective versus universal screening for thyroid dysfunction (TD) during pregnancy.Material and methods
Cross-sectional study applying a selective screening protocol, based on the presence of TD risk factors (RF), in a cohort of pregnant women with a positive universal screening result in the Oviedo Healthcare District. Two hundred and twenty pregnant women with TD were studied between April 2010 and March 2011.Results
Selective screening identified 83.6% of pregnant women with TD. The most prevalent RF were maternal age ≥ 30 years (70.5%), history of miscarriage (21.8%) and family history of thyroid disease (20.9%). Excluding the age factor, only 51.8% of the pregnant women included in the group had risk factors.Conclusions
Selective screening identifies a high proportion of pregnant women with TD but at the expense of screening a large number of women, so it does not appear to be an effective strategy. 相似文献1000.
Ana Rita Lameiras Hugo Estibeiro Pedro Montalvão Miguel Magalhães 《Acta otorrinolaringologica espanola》2019,70(2):74-79