全文获取类型
收费全文 | 161211篇 |
免费 | 16555篇 |
国内免费 | 6858篇 |
专业分类
耳鼻咽喉 | 2683篇 |
儿科学 | 1965篇 |
妇产科学 | 2147篇 |
基础医学 | 16300篇 |
口腔科学 | 3784篇 |
临床医学 | 13250篇 |
内科学 | 22088篇 |
皮肤病学 | 2611篇 |
神经病学 | 891篇 |
特种医学 | 6870篇 |
外国民族医学 | 227篇 |
外科学 | 19168篇 |
综合类 | 29352篇 |
现状与发展 | 33篇 |
预防医学 | 5240篇 |
眼科学 | 1174篇 |
药学 | 10499篇 |
71篇 | |
中国医学 | 5114篇 |
肿瘤学 | 41157篇 |
出版年
2024年 | 464篇 |
2023年 | 2656篇 |
2022年 | 5275篇 |
2021年 | 7006篇 |
2020年 | 6181篇 |
2019年 | 5350篇 |
2018年 | 5155篇 |
2017年 | 5979篇 |
2016年 | 6618篇 |
2015年 | 7330篇 |
2014年 | 10707篇 |
2013年 | 9922篇 |
2012年 | 9681篇 |
2011年 | 10485篇 |
2010年 | 8334篇 |
2009年 | 8014篇 |
2008年 | 8205篇 |
2007年 | 8711篇 |
2006年 | 7909篇 |
2005年 | 7062篇 |
2004年 | 5700篇 |
2003年 | 4932篇 |
2002年 | 4135篇 |
2001年 | 3884篇 |
2000年 | 3255篇 |
1999年 | 2651篇 |
1998年 | 2352篇 |
1997年 | 2215篇 |
1996年 | 1912篇 |
1995年 | 1657篇 |
1994年 | 1576篇 |
1993年 | 1108篇 |
1992年 | 1050篇 |
1991年 | 920篇 |
1990年 | 774篇 |
1989年 | 692篇 |
1988年 | 626篇 |
1987年 | 539篇 |
1986年 | 430篇 |
1985年 | 467篇 |
1984年 | 453篇 |
1983年 | 306篇 |
1982年 | 334篇 |
1981年 | 271篇 |
1980年 | 290篇 |
1979年 | 203篇 |
1978年 | 148篇 |
1977年 | 115篇 |
1976年 | 97篇 |
1975年 | 61篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
《Neuro-Chirurgie》2022,68(2):196-201
BackgroundTumor-to-tumor metastases are extremely rarely reported lesions, which usually involve an indolent lesion hosting a more aggressive neoplasm. We present an unusual initial manifestation of a previously unknown clear cell renal cell carcinoma as a tumor-to-tumor metastasis in a typical meningothelial meningioma.Case reportA 73-year old patient with transient left slight monoparesis was addressed to our Neurosurgical Department after being evaluated by his general practitioner and passing a cerebral MRI which revealed a right frontotemporal mass attached to the meninge. At presentation, no deficits were identified; therefore an elective surgery was proposed. Histological analysis revealed a typical meningothelial meningioma containing a metastatic clear cell renal cell carcinoma. Additional thoraco-abdominal computer tomography identified a 6 cm diameter lesion within the right kidney with radiological features highly suggestive of a primary clear cell renal cell carcinoma.ConclusionOur case highlights the need for a specialized neuropathological approach to clinical and imagistic indolent meningiomas, as they may require important differential diagnosis that can highly impact the treatment and follow-up of brain tumor patients. 相似文献
62.
63.
I Ahmad 《Annals of the Royal College of Surgeons of England》2015,97(7):481-486
Urothelial cell carcinoma (UCC) of the bladder is one of the most common malignancies, causing considerable morbidity and mortality worldwide. It is unique among the epithelial carcinomas as two distinct pathways to tumourigenesis appear to exist: low grade, recurring papillary tumours usually contain oncogenic mutations in FGFR3 or HRAS whereas high grade, muscle invasive tumours with metastatic potential generally have defects in the pathways controlled by the tumour suppressors p53 and retinoblastoma. Over the last two decades, a number of transgenic mouse models of UCC, containing deletions or mutations of key tumour suppressor genes or oncogenes, have helped us understand the mechanisms behind tumour development. In this summary, I present my work investigating the role of the WNT signalling cascade in UCC. 相似文献
64.
65.
Taisuke Inada Satoshi Fukushima Masayuki Murai Masatoshi Jinnin Azusa Miyashita Satoshi Nakahara Junji Yamashita Jun Aoi Shinichi Masuguchi Hironobu Ihn 《The Journal of dermatology》2015,42(2):198-201
miRNA‐221 (miR‐221) is known to be abnormally expressed in many human cancers. The serum levels of miR‐221 have been reported as a tumor marker for malignant melanoma (MM). We hypothesized that the hair shaft miR‐221 levels may be increased in patients with MM. We therefore assessed the possibility that hair shaft miR‐221 levels could be a marker for MM. The hair shaft miR‐221 levels were significantly higher in patients with MM than controls. The rates of increased hair shaft miR‐221 levels above the cut‐off value were comparable to those of serum 5‐S‐CD, which is a tumor marker commonly used for MM. Measurements of the hair shaft miR‐221 levels could have potential clinical value in the detection of MM. This is the first report investigating the hair shaft levels of an miRNA in patients with MM. Our investigations offer new insight into the relationship between miR‐221 and MM, and may provide a new, non‐invasive way to screen for melanoma. 相似文献
66.
67.
《Cancer cell》2021,39(11):1497-1518.e11
- Download : Download high-res image (282KB)
- Download : Download full-size image
68.
69.
70.