Reproducibility of Computerized Measurements of QT Interval from Multiple Leads at Rest and During Exercise

Background: Accurate measurement of the QT interval is important for diagnosing long QT syndrome (LQTS), and in research on determinants of ventricular repolarization time. We tested automatic analysis of QT intervals from multiple ECG leads on chest. Methods: Eleven healthy volunteers and 10 genotyped LQTS patients were tested at rest and during exercise with a bicycle ergometer twice 1–31 months apart. Electrocardiograms were recorded with the body surface potential mapping system, and 12 precordial channels were selected for analysis. Averaged QT peak and QT end intervals were determined with an automated algorithm, and the difference QT end minus QT peak (Tp‐e) was calculated. Repeatability was assessed by coefficient of variation (CV) between measurements. Results: Within one test at rest the QT end intervals were highly repeatable with CV 0.6%. In repeated tests CV was 4.4% for QT end interval and 3.5% when the QT interval was corrected for heart rate. In exercise test at specified heart rates, mean CV was 3.0% for QT end and 2.9% for QT peak interval. The CV of Tp‐e interval was 10.2% at rest, and 9.3% in exercise test. Reproducibility was comparable between healthy subjects and LQTS patients. Conclusions: The BSPM system with automated analysis produced accurate and highly repeatable QT interval measurements. Reproducibility was adequate also over prolonged time periods both at rest and in exercise stress test. The method can be applied in studying duration of ventricular repolarization time in different physiologic and pharmacologic interventions.     

Clinical Study on Long-Term Treatment of Ankylosing Spondylitis with Integrative Medicine

Ａｎｋｙｌｏｓｉｎｇｓｐｏｎｄｙｌｉｔｉｓ（ＡＳ）ｉｓａｒｈｅｕｍａｔｉｃｄｉｓｅａｓｅｗｉｔｈｈｉｇｈｉｎｃｉｄｅｎｃｅ，ｉｎｄｕｃ ｉｎｇｄｉｓａｂｉｌｉｔｙａｎｄｉｎｖａｄｉｎｇｔｈｅｓｐｉｎａｌａｘｉａｌｊｏｉｎｔａｓｉｔｓｃｈｉｅｆｃｈａｒａｃｔ     

根管治疗术远期疗效的影响因素

根管治疗术（root canal therapy,RCT）是治疗牙髓病、根尖周病的主要方法.影响根管治疗术远期疗效的因素较多,而RCT前根尖周状态和根充位置是两大主要因素.     

谷参肠安胶囊长期毒性试验

本文报告谷参肠安胶囊大鼠长期毒性试验,结果表明,谷参肠安胶囊对动物的一般状况,体重增长、外周血象、肝肾功能及病理组织学检查等未见明显毒性。     

胎儿脐带缠绕253例分析

目的　探讨胎儿脐带缠绕的临床意义及处理。方法　分析 2 5 3例有脐带缠绕的孕妇的脐带长度、剖宫产率、脐动脉血流S/D的值及对围产儿的影响 ,并与 2 6 9例无脐带缠绕者作比较。结果　 2 5 3例脐带缠绕组中脐带过长者明显高于无脐带缠绕组 (P <0 .0 1)。因脐带缠绕组中脐动脉血流S/D值≥ 3.0的百分率、胎儿宫内窘迫的发生率及新生儿窒息率明显高于对照组 (P <0 .0 1) ,故临床剖宫产率也高于对照组。结论　脐带缠绕可对围产儿造成不良影响 ,临床应提高孕期监测、产程监护 ,从而减少对围产儿的影响 ,降低不必要的剖宫产     

中长跑和芭蕾舞运动中胫骨应力骨折的比较

胫骨应力骨折（ＳＦ）在芭蕾舞和中长跑运动员中均有一定发病率，作者调查某部新兵２６５人每日５０００米跑步，其胫骨应力骨折病发率为１１．６８％（３１／２６５人），骨折部位多在胫骨中段中后侧。芭蕾舞演员胫骨应力骨折病发率为８％（１５／６０人），骨折部位在胫骨下段前侧。应用新鲜尸体标本作负荷下胫骨多处的应变测定模拟跑步和足跟垫高模仿芭蕾舞时下肢负重位置的应变变化，分别于胫骨中段后侧测得有高压应力和胫骨下段前方有高张应力，此结果与调查中Ｘ线片病变部位相符。作者认为不同的运动使负重时胫骨所处姿势各不相同，而造成胫骨最大应力集中点位置各异，是造成芭蕾舞运动和中长跑运动中应力骨折部位不同的主要原因，预防和治疗工作应根据各自的应力性质和集中点部位来进行防治。     

Long QT interval syndrome with increased QT dispersion

This case report describes the anaesthetic management of a patient with sporadic-type long QT interval syndrome (LQTS), and increased QT dispersion, who presented for removal of an ovarian cyst. Beta adrenergic blockade and adequate depth of anaesthesia for successful management is emphasized. The Successful use of epidural administration of lignocaine and opioids in addition to general anaesthesia is described.