2013—2020年辽宁红沿河核电站周围地区的食品放射性水平及公众内照射剂量研究

目的 评价辽宁红沿河核电站运行后对周边地区食品放射性水平的影响。方法 通过对2013年至2020年核电站运行期间周边30 km范围内食品放射性水平的分析,对比核电站运行前后及对照点的放射性水平,评估核电站的运行对当地食品放射性水平的影响。结果 当地食品中未发现¹³¹I、¹³⁴Cs、⁶⁰Co、⁵⁸Co、¹¹⁰Ag^m等人工放射性核素,天然放射性核素²³⁸U、²²⁶Ra、²³²Th、⁴⁰K均在正常本底水平,平均值分别为（0.088±0.053）、（0.155±0.178）、（0.314±0.388）和（81.3±18.1） Bq/kg （鲜重）。食品样品中人工放射性¹³⁷Cs活度浓度平均值为（0.013±0.010） Bq/kg （鲜重）。与对照点及运行前水平比较,放射性核素水平未见增加。结论 红沿河核电站的运行未对周边食品放射性水平带来影响。     

子宫内膜异位症患者行随访性护理对其术后激素水平的影响

目的探究子宫内膜异位症患者行随访性护理干预对其术后激素水平的影响。方法择取2018年6月至2019年11月本院妇科收治的100例子宫内膜异位症手术患者,根据抽签法进行随机分组,其中对照组50例,观察组50例。对照组行常规护理,观察组行随访性护理,比较两组患者激素水平和总护理满意度。结果观察组患者激素水平低于对照组,经统计学比较组间差异有意义(P<0.05);观察组患者总护理满意度高于对照组,经统计学比较组间差异有意义(P<0.05)。结论随访性护理干预的应用可以降低子宫内膜异位症患者术后激素水平,有利于促进其康复,并提升对护理服务的满意度。     

Non-enzymatic glycosylation of serum proteins as an indicator of diabetic control

Summary In 44 diabetic patients treated either with insulin or with oral antidiabetic agents, non-enzymatic glycosylation of serum proteins (GSP), expressed as nmol of 5-hydroxymethylfurfural/mg protein, showed higher values than those found in control subjects. In the diabetics GSP was more closely correlated to the degree of glycometabolic control during the 15 days preceding the assay, than to the glycosylated hemoglobin (HbAl). However, GSP values did not correlate significantly with fasting blood glucose levels. It may be concluded that GSP can be used as an index of the medium-term control of diabetes mellitus.     

早产SGA产后24 h内血清Ghrelin、IGF－1、INS水平与胎龄及体格发育指标相关性分析

目的：研究早产小于胎龄儿（SGA）产后24 h血清中Ghrelin、胰岛素样生长因子（IGF－1）、胰岛素（INS）水平与胎龄以及发育指标的相关性。方法收集我院产科2006－10～2013－10间的出生的早产SGA500例,按照出生体重将病例分为三组：1000～1500 g的为A组（121例）,1500～2000 g的为B组（245例）,2000～2500 g的为C组（134例）,所有的患者分别于开奶前抽取静脉血2～3 mL,离心去血清后分别测定Ghrelin、IGF－1、INS水平,研究与胎龄以及体格发育的相关性。结果早产SGA产后24 h内血清Ghrelin随着体重的增加而逐渐降低,并且经过统计学检验三组之间的差异具有统计学意义（ P＜0．05）, IGF－1、INS水平随着体重的增加逐渐升高,并且两种因素在三组之间的差异均具有统计学意义（ P＜0．05）;利用Pearson相关性分析显示,早产SGA产后24 h内血清Ghrelin水平与胎龄、出生体质量、身长、BMI呈负相关,而与出生头围相关性不明显;IGF－1水平与胎龄、出生体质量、身长、头围、BMI 呈正相关;INS水平与胎龄、出生体质量、身长、头围、BMI呈正相关。结论早产SGA产后24 h内血清Ghrelin、IGF－1、INS水平与胎龄及体格发育指标之间具有明显的相关性,同时可以将Ghrelin、IGF－1、INS水平作为婴儿体格发育的有效的指标。     

Relationship between lipids levels and right ventricular volume overload in congestive heart failure

BackgroundThe relationship between lipids and coronary artery disease has been well established. However, this is not the case between lipids and heart failure. Ironically, high lipid levels are associated with better outcomes in heart failure, but the mechan-isms underlying the phenomenon are not fully understood. This study was performed to test the hypothesis that reduced intestinal lipid absorption due to venous congestion may lead to low lipid levels.MethodsWe collected data of clinical characteristics, echocardio-graph, and lipid profile in 442 unselected patients with congestive heart failure. Correlations between lipid levels[including total cho-lesterol（TCL）, high-density lipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol（LDL-C）, and triglycerides（TG）]and right ventricle end diastolic diameter （RVEDD）, left ventricle end diastolic diameter （LVEDD）, right atrium diameter （RA）, left atrium diameter （LA）, or left ventricle ejection fraction （LVEF） were analyzed using Pearson correlation and partial correlation. RVEDD, LVEDD, RA, and LA were indexed to the body surface area.ResultsThere was a significantly inverse correlation between TCL le-vels and RVEDD （r=-0.34,P〈0.001） and RA （r=-0.36,P〈0.001）. Other lipids such as LDL-C, HDL-C, and TG had asimilar inverse correlation with RVEDD and RA. All these correlations remained unchanged after adjusting for age, gender, smoking status, physical activity levels, comorbidities, and medication use.ConclusionsLipid levels were inversely correlated to RVEDD in patients with congestive heart failure; however, because this was an observational study, further investigation is needed to verify our results as wellas identify a causal relationship, if any.     

Upregulated Expression of AQP 7 in the Skeletal Muscles of Obese ob/ob Mice

Aquaporin (AQP) is suggested to be regulated by leptin through the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway. AQP7 and AQP9 are membrane proteins with water and glycerol channels, the latter of which is essential for triglyceride synthesis. We conjectured that the expression of AQP7 and AQP9 would be altered in the skeletal myofibers in obese leptin deficient ob/ob mice as compared with that of wild mice. RNA and protein levels were studied in the quadriceps femoris muscles of ob/ob and wild mice. Real time quantitative RT-PCR analysis showed that mouse AQP7 mRNA levels in skeletal muscles were significantly higher in ob/ob mice than in wild mice (P<0.01), whereas mouse AQP9 mRNA level was not different between the two groups (P>0.05). Histologically the type 1 myofibers of ob/ob mice contained numerous lipid droplets in oil red O stain samples. Immunohistochemical staining of ob/ob mouse muscles revealed enhanced expression of AQP7 at myofiber surface membranes, while AQP9 expression appeared to be similar to that of wild mice. The findings suggest that the upregulated expression of AQP7 in ob/ob mouse muscles facilitates the secretion of glycerol from myocytes.     

中年男性Ⅱ型糖尿病患者基线血尿酸水平与冠状动脉病变的比较

目的:探讨中年男性Ⅱ型糖尿病患者基线血清尿酸(SUA)水平与冠状动脉病变程度的关系。方法:192例疑诊为急性冠状动脉综合征,并冠状动脉造影检查病变为阴性的中年男性患者,根据血糖分为糖尿病组及血糖正常组。5年后,再次发生急性冠状动脉综合征为终点事件并复查冠状动脉造影。应用冠状动脉狭窄指数(CSI)评价冠状动脉病变程度。结果:①糖尿病组与血糖正常组比较基线,SUA水平明显升高(P=0.028)、脂代谢紊乱尤以TC(P=0.012)、LDL-C(P=0.003)升高明显;CSI(P=0.001)、冠状动脉病变支数(P=0.000)及冠状动脉病变的确诊率(χ2=5.650,P=0.017)也明显增高。②经Spearman相关分析显示糖尿病组患者基线SUA水平与CSI、冠状动脉病变支数及冠状动脉病变患病率存在明显的相关性,相关系数分别为:r=0.474(P=0.001)、r=0.325(P=0.026)及r=0.301(P=0.040)。结论:中年男性Ⅱ型糖尿病患者基线SUA水平,与冠状动脉病变的发生发展存在着明显的相关性。