An update on atypical large glandular proliferations of the prostate

The differential diagnosis of prostatic atypical large gland proliferations includes several benign and malignant entities. This review focusses on issues relevant to the practising pathologist, particularly around areas of controversy such as high-grade prostatic intraepithelial neoplasia (HGPIN) and intraductal carcinoma of the prostate (IDCP). HGPIN is a putative precursor of prostate cancer, but its clinical relevance is as a surrogate marker of unsampled prostate cancer, thereby identifying patients who would benefit from a prompt repeat biopsy. The incidence of missed prostate cancer is much lower in contemporary practice due to pre-biopsy MRI and extended sampling protocols so HGPIN is currently less important. It is however important to distinguish HGPIN from PIN-like carcinoma and IDCP. PIN-like carcinoma is considered a histological subtype/variant of acinar prostate carcinoma and should be graded as Gleason pattern 3. A diagnosis of cribriform HGPIN should not be made in needle biopsies as such a proliferation may represent IDCP. This review discusses controversies related to the diagnosis, reporting and management of IDCP. A personalized approach to management of patients with isolated IDCP in needle biopsies that is based on the histological and radiological features of an individual case is outlined.     

基于点云数据的髋臼置钉通道全局优化

针对髋臼前后柱置钉通道多截面调控规划法的不足,该研究提出了基于大密度点云数据、相关理论、软件内置功能及自编程序的规划方法,实现了对置钉通道总长的全局优化,同时进行了基于7截面、11截面调控规划法以及点云数据的前柱最大内接圆柱体虚拟置钉实验,分析了实验结果及形成机理,验证了基于点云数据规划法的全局优化效果,但对多截面调控规划法的调控有效性表示还存有疑问,此外,还对基于点云数据的髋臼置钉通道规划方法应用的相关原理和操作技巧作了简略介绍。     

3D打印导板辅助上颈椎椎弓根置钉与徒手置钉的比较

目的 比较个体化3D打印导板辅助上颈椎椎弓根置钉与徒手置钉的精准性。方法 选择2019年6月至2022年6月在蚌埠医学院第二附属医院就诊的上颈椎疾患患者20例,获取每位患者颈椎三维CT数据,根据置钉方式不同分为导板组和对照组,分别制作20例等比例3D打印上颈椎模型,导板组使用3D打印导板辅助上颈椎模型椎弓根螺钉置入,对照组在透视辅助下徒手置钉。根据椎体是否存在骨折,将导板组内20例模型分为钉道损伤组10例（寰椎骨折与枢椎骨折病例）和钉道完整组10例（畸形与关节脱位病例）。比较导板组和对照组螺钉可接受率、单枚螺钉置入时间差异;比较导板组术前理想钉道与术后实际钉道内倾角差异,对比钉道损伤组和钉道完整组置钉结果差异。结果 导板组螺钉可接受率为93.55%,高于对照组的79.03%(P<0.05);导板组单枚螺钉置入时间短于对照组（P<0.05）;导板组术前理想螺钉内倾角与术后实际螺钉内倾角之间差异无统计学意义（P>0.05）;钉道损伤组螺钉突破椎弓根率26.7%高于钉道完整组3.1%(P<0.05)。结论 个体化3D打印导板辅助上颈椎椎弓根置钉在置钉精准度、安全性和置...     

国人牙直丝托槽定位值的测量研究

为建立适合国人牙直丝托槽定位值,选择符合Ａｎｄｒｅｗ ｓ 正常牙合成年人６０ 例,男女各３０ 例,１８～２１ 岁,平均１９．２ 岁,均具有协调的面部比例,未接受正畸治疗。弓丝平面定义为大多数牙临床牙冠中点所在的平面,用游标卡尺测量每一牙齿切缘（或牙合缘）,至弓丝平面的距离,为直丝托槽应就位的位置。结果显示,托槽并非全部位于每个牙的临床牙冠中点,在上颌双尖牙区,托槽位于临床牙冠中点龈方０．５ｍ ｍ 处,第二磨牙托槽位于临床牙冠中点偏牙合方０．５ｍ ｍ ～１．０ｍ ｍ 处,在下颌尖牙及第一、二磨牙处,托槽位于临床牙冠中点偏牙合方０．５ｍ ｍ 处。表明本研究建立的托槽定位值适合于国人,且可明显提高直丝托槽垂直置入精确度     

Variability in the stereotaxic position of cerebral points in the albino rat

An analysis of variability in the stereotaxic position of five cerebral points in rats revealed:

1. (1) that variability was less from the bregma skull point than from ear-bar-zero or the lambda skull point,

2. (2) that high correlations exist between the position of skull points and cerebral structures, and

3. (3) that the use of two external landmarks for predicting the position of cerebral targets produces a greater than 40% reduction in errors over that resulting from the use of single (ear-bar-zero or skull landmark) predictors.

乳腺导管内乳头状瘤的导管造影诊断

目的 评价导管造影检查对导管内乳头状瘤的诊断价值.方法 观察51例经手术病理证实的导管内乳头状瘤的临床特征及导管造影钼靶照片表现.结果 导管内乳头状瘤在导管造影钼靶照片上表现为典型的充盈缺损、局部导管扩张;导管造影对乳腺导管内乳头状瘤的敏感性为74.5%（38/51）,定位准确率为98%（50/51）.结论 导管造影是目前导管内乳头状瘤较可靠的诊断方法,结合临床特征及触诊检查,仔细操作,可提高诊断率与定位的准确性.     

Monitoring the development of clinical skills during training in a clinical placement

Background The education and training of health care practitioners has undergone recent reform, and indicate that curricula should place emphasis on the development of clinical skills and attitude. The purpose of this study was two‐fold: to define the key skills necessary for a competent dietetic student practitioner and to devise a reliable assessment tool to measure and track performance in these key skill areas throughout the period of clinical placement. Methods Key clinical skills were identified by a concensus group of experienced dietitians and academic practitioners. An assessment tool was then developed to measure these attributes in 43 students undertaking clinical placement at a number of training centres in Scotland. Development of skills was tracked for the entire duration of placements using the novel assessment tool. The assessment tool used a visual analogue scale (VAS) as the measuring score. Results A high level of skill attainment was equated with high VAS scores. Performance in three of the four key skills (written skills: r = 0.762, P ≤ 0.001; interviewing skills: r = 0.697, P < 0.001; and dietary assessment technique: r = 0.697, P ≤ 0.001) showed impressive correlation co‐efficients, indicating a striking and significant positive correlation with the length of training. A high skill performance level attainment was achieved by week 16/17 of training. Conclusion The authors are confident that the assessment tool is valid and reliable and measures skill performance objectively. A high level of skill attainment was observed in most students by about the mid‐point in training: this allows the student to consolidate these skills in the latter stages of training which is in keeping with educational and practice philosophy of placement learning outcomes.     

The testing of clinical skills in dietetic students prior to entering clinical placement

Background One of the most important requirements for contemporary education of a health care professional is to develop a framework for theory and practise which results in attainment of professional competencies suitably robust for a lifetime of practise ( Howe, 2002 ). In the context of those educating preregistration dietitians, this offers the challenge of presenting the student with innovative curricula designed to deliver the appropriate level of knowledge and understanding together with emphasis on skill and attitude development. The purpose of this study was to allow preregistration students the opportunity to practise key clinical skills prior to clinical placement and test skills acquisition using the model of an objective structured clinical examination (OSCE). Methods The learning experience of the student was altered to accommodate a more conceptually‐driven, problem‐centred, case‐based approach. The curriculum was adjusted to incorporate a short clinical skills programme where emphasis was deliberately placed on skill acquisition. At the conclusion of this clinical skills programme, and prior to the students entering clinical placement, skill performance by students was tested using the OSCE. The method of testing was also evaluated by students. Results The OSCE was delivered to 37 preclinical students. Four of the test candidates (11%) failed in at least one of the skill areas: these students performed similarly during clinical placement. Twenty‐one (57%) students returned the post‐OSCE questionnaire. Twenty (95%) students reported a positive experience; 20 (95%) students reported initial anxiety that diminished as the test progressed. Conclusion The Project Team was confident with the novel approach taken in re‐designing the curriculum: to include a dedicated clinical skills programme, together with addition of the testing of clinical skills using the OSCE model. These curriculum changes were deemed to be highly appropriate additions to the student experience in determination of skill performance of students prior to clinical placement.