不同消毒方法对胃肠镜的消毒效果比较

目的观察不同消毒方法对胃肠镜的清洗消毒效果,确保内镜清洗消毒质量。方法采用冲洗法采样和细菌定量检验方法,对两种清洗消毒方法对胃肠镜清洗消毒效果进行了比较检测。结果在清洗干净的基础上,将1条胃镜浸泡于20 g/L戊二醛消毒液内消毒10 min,消毒效果合格率为97.14%;将2条胃镜同时浸泡于20 g/L戊二醛消毒液内消毒10 min,消毒效果合格率为84.38%。将1条肠镜浸泡于20 g/L戊二醛消毒液内消毒15 min,消毒效果合格率为100%;将2条肠镜同时浸泡于20 g/L戊二醛消毒液内消毒15 min,消毒效果合格率为66.67%。结论用戊二醛消毒液浸泡消毒胃肠镜,最好每次浸泡消毒1条胃镜或肠镜,能够确保消毒质量。     

Comprehensive gastroenterology endoscopy unit workflow and infection prevention during the COVID‐19 Pandemic: Experience with 159 cases in Wuhan,China

During the outbreak of the novel coronavirus disease (COVID‐19) in Wuhan, the gastroenterology department of our hospital performed gastrointestinal endoscopy procedures using strict infection control measures. Thorough screening of incoming patients, separation of diagnostic and treatment areas, regional management, hierarchical protection, disinfection protocols, and other measures were enforced to prevent virus transmission during endoscopic treatments. During the COVID‐19 pandemic, between February and March 2020, 159 endoscopic examinations and treatments were performed, including emergency endoscopy for 17 patients. Among these, seven patients were either previously infected with or were suspected carriers of the virus. Using the aforementioned control measures, we did not encounter a single case of cross‐infection or infection among the patients or staff. The presented protocols may provide valuable insight regarding how to protect gastroenterology endoscopy units during the novel coronavirus disease pandemic.     

蛋白质组学技术用于功能性胃肠病研究

目的:探讨将蛋白质组学方法用于功能性胃肠病发病机制研究的可行性。方法:选择发病率较高的肠易激综合征(irritable bowel syndrome,IBS)亚型患者作为研究对象,运用蛋白质组学方法,双向凝胶电泳后应用不同染色方法进行染色,Image Master 2D Elite分析软件对图像进行分析。结果:考马斯亮蓝法染色用于腹泻型IBS患者,平均得到蛋白质点426个;硝酸银染色法用于便秘型IBS患者,平均得到蛋白点581个。结论:双向凝胶电泳法可得到IBS患者结肠黏膜组织的蛋白质组图谱;硝酸银染色法的分辨率明显高于考马斯亮蓝法。     

消化内科老年患者医院感染病原菌分布、危险因素分析及对策研究

目的：探讨消化内科老年患者医院感染病原菌分布、危险因素分析及对策研究。方法：选取2019年5月至2022年10月收治的265例消化内科老年患者作为研究对象,根据患者住院期间是否发生感染分为感染组（n=87）与非感染组（n=178）,观察消化内科并发医院感染老年患者的感染部位及经菌株分离培养后的病原菌分布情况;采用二元logistic回归模型分析影响消化内科老年患者并发医院感染的危险因素。结果：265例消化内科老年患者发生感染共87例,其中呼吸道感染33例、泌尿系统感染15例、消化系统感染20例、皮肤软组织感染13例、导管相关血流感染6例。87例消化内科并发医院感染老年患者经细菌培养分离出87株病原菌,其中革兰阳性菌共28株（32.18%）,革兰阴性菌共52株（59.77%）,真菌共7株（8.05%）。感染组与非感染组在性别、病程、高血压史、吸烟史、饮酒史、体质指数等基线资料比较中,差异无统计学意义（P>0.05）;而在年龄、抗生素使用时间、住院时间、机械通气、糖尿病、留置导尿管、血红蛋白、白蛋白、留置胃管等基线资料比较中,差异具有统计学意义（P<0.05）。logistic...     

Hypertriglyceridemia‐induced pancreatitis after egg retrieval for in vitro fertilization and fenofibrate cessation

A 36‐year‐old woman with prior hypertriglyceridemia‐induced pancreatitis presented with a recurrence of pancreatitis after beginning in vitro fertilization (IVF). Her primary care physician had discontinued fenofibrate due to concerns for teratogenicity. This case illustrates the importance of fibrate therapy for high‐risk women undergoing IVF, despite limited evidence regarding its teratogenicity.     

Cow's milk allergy non‐responsive to amino acid‐based formula? A successful transplanted patient with immune dysregulation,polyendocrinopathy, enteropathy,and X‐linked syndrome

The wide variety of IPEX symptoms leads to diagnosis and treatment delay with fatal outcomes if left untreated before two first years of life. Cow''s milk allergy non‐responsive to amino acid‐based formula must raise suspicion of this syndrome.