全文获取类型
收费全文 | 8504篇 |
免费 | 853篇 |
国内免费 | 1231篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 25篇 |
妇产科学 | 13篇 |
基础医学 | 371篇 |
口腔科学 | 124篇 |
临床医学 | 340篇 |
内科学 | 733篇 |
皮肤病学 | 291篇 |
神经病学 | 127篇 |
特种医学 | 475篇 |
外科学 | 166篇 |
综合类 | 1348篇 |
现状与发展 | 2篇 |
一般理论 | 1篇 |
预防医学 | 627篇 |
眼科学 | 101篇 |
药学 | 2852篇 |
3篇 | |
中国医学 | 2818篇 |
肿瘤学 | 157篇 |
出版年
2024年 | 68篇 |
2023年 | 161篇 |
2022年 | 357篇 |
2021年 | 409篇 |
2020年 | 295篇 |
2019年 | 232篇 |
2018年 | 230篇 |
2017年 | 326篇 |
2016年 | 346篇 |
2015年 | 378篇 |
2014年 | 581篇 |
2013年 | 732篇 |
2012年 | 604篇 |
2011年 | 703篇 |
2010年 | 547篇 |
2009年 | 495篇 |
2008年 | 511篇 |
2007年 | 413篇 |
2006年 | 460篇 |
2005年 | 377篇 |
2004年 | 291篇 |
2003年 | 267篇 |
2002年 | 222篇 |
2001年 | 218篇 |
2000年 | 127篇 |
1999年 | 127篇 |
1998年 | 130篇 |
1997年 | 101篇 |
1996年 | 102篇 |
1995年 | 86篇 |
1994年 | 89篇 |
1993年 | 76篇 |
1992年 | 89篇 |
1991年 | 61篇 |
1990年 | 51篇 |
1989年 | 40篇 |
1988年 | 45篇 |
1987年 | 44篇 |
1986年 | 31篇 |
1985年 | 32篇 |
1984年 | 16篇 |
1983年 | 25篇 |
1982年 | 15篇 |
1981年 | 14篇 |
1980年 | 17篇 |
1979年 | 15篇 |
1978年 | 9篇 |
1977年 | 6篇 |
1976年 | 8篇 |
1974年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
The problem of designing strategies for optimal feedback control of non‐linear processes, specially for regulation and set‐point changing, is attacked in this paper. A novel procedure based on the Hamiltonian equations associated to a bilinear approximation of the dynamics and a quadratic cost is presented. The usual boundary‐value situation for the coupled state–costate system is transformed into an initial‐value problem through the solution of a generalized algebraic Riccati equation. This allows to integrate the Hamiltonian equations on‐line, and to construct the feedback law by using the costate solution trajectory. Results are shown applied to a classical non‐linear chemical reactor model, and compared against suboptimal bilinear‐quadratic strategies based on power series expansions. Since state variables calculated from Hamiltonian equations may differ from the values of physical states, the proposed control strategy is suboptimal with respect to the original plant. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
32.
Thirty-six Australian Aboriginal children with urolithiasis were reviewed. Males dominated the series. The age distribution ranged from 8 months to 12 years and nearly 70% were 2 years or younger. Thirty-five patients had upper tract stones. Ultrasound was diagnostic in 35 patients and was falsely negative in one. Dietary factors, dehydration and recurrent diarrhoea are incriminated in the aetiology, because ammonium urate and oxalate were the main constituents of the stones. Malformations of the urinary tract were rare and known metabolic disorders were not seen. Chemical dissolution of the stones was found to be a safe and effective adjuvant in the management of urate stones. 相似文献
33.
A membrane-coated fiber (MCF) array approach was developed for quantitative assessment of skin absorption from chemical mixtures, which was based on the similarity in the absorption mechanisms of the MCF membrane and the stratum corneum of the skin. A set of probe compounds were used to detect the relative molecular interaction strengths of chemicals with the vehicle and the membranes, which provided a linkage between the skin permeability (log k) and MCF partition coefficients (log KF). A predictive model was established via multiple linear regression analysis of the data matrix of experimentally measured log k value and log KFm values; log k=a0+a1 log KF1+a2 log KF2+...+an log KFm, where m is the number of diverse MCFs. Twenty-five probe compounds and three MCFs (polydimethylsiloxane for lipophilic, polyacrylate for polarizable, and CarboWax for polar interactions) were used to demonstrate the model development processes in the MCF array approach. The skin permeability of the probe compounds was measured with conventional diffusion cell experiments using dermatomed porcine skin. Three predictive models were established for skin permeability prediction from chemical mixtures in water, 50% ethanol, and 1% sodium lauryl sulfate (SLS) with R2 values of 93, 91, and 83, respectively. The log k and log KF values were considerably altered by the addition of ethanol or SLS into the dose vehicle; however, their correlations to skin permeability remained strong under various conditions. These results suggested that the experimentally based MCF array approach can be used to predict skin absorption from chemical mixtures in different vehicles or formulations. 相似文献
34.
The effects of chemical fixation are known to alter MR parameters, such as relaxation times and the apparent diffusion coefficient (ADC) of water. It is often assumed that such changes are reversible after samples have been reimmersed in a buffer solution for a sufficient period of time. In this study we characterize the changes associated with fixation of single Xenopus laevis oocytes and their subsequent reimmersion in buffer. Substantial reductions in both T(1) and T(2) values were measured for all compartments of the cell after fixation, with the cytoplasm showing larger changes than the nucleus. After reimmersion in buffer, there were small but statistically significant differences in MR parameters between fresh and reimmersed cells. Experiments with a gadolinium (Gd) contrast agent showed evidence of irreversible changes in the permeability of cellular membranes to small molecules. 相似文献
35.
Kagayaki Kuroda Daisuke Kokuryo Etsuko Kumamoto Kyohei Suzuki Yuichiro Matsuoka Bilgin Keserci 《Magnetic resonance in medicine》2006,56(4):835-843
Referenceless, or self-reference, thermometry is a technique for mapping temperature differences in the region of interest (ROI) using the baseline phase estimated by extrapolating the field in the surrounding region for estimation (RFE) and subtracting the estimated baseline from the measured field. In the present work a self-reference technique based on complex field estimation using 2D polynomials comprising complex-valued coefficients was proposed and optimized. Numerical simulations with a Gaussian-profiled phase distribution demonstrated that the ROI radius had to be 2.3-2.5 times the standard deviation (SD) of the Gaussian function in order to keep the error below 8% of the peak phase change. The area ratio between the ROI and the RFE had to be larger than 2.0 to maintain the error level. Based on the simulations, and phantom and volunteer experiments, the complex-based method with independently optimized polynomial orders for the two spatial dimensions was compared with the phase-based method using the similar-order optimization strategy. The complex-based method appeared to be useful when phase unwrapping was not removed. Otherwise, the phase-based method yielded equivalent results with less polynomial orders. 相似文献
36.
Leoncio Garrido Bettina Pfleiderer Bruce G. Jenkins Carol A. Hulka Daniel B. Kopans 《Magnetic resonance in medicine》1994,31(3):328-330
Studies using magnetic resonance spectroscopy in human volunteers to evaluate their livers in vivo and to analyze their blood in vitro suggest that there are measurable amounts of silicon compounds in the blood of some women with implants and that there is migration of silicone to other organs such as the liver. 相似文献
37.
Grant R. Caddy MD MRCP Consultant Gastroenterologist Tony C.K. Tham MD FRCP Consultant Gastroenterologist 《Best Practice & Research: Clinical Gastroenterology》2006,20(6):1085
Symptomatic BDS commonly cause significant morbidity and attempt at stone removal should be attempted if possible. Complications of CBDS include biliary colic, jaundice, cholangitis and pancreatitis. Investigations aimed to predict the presence of stones within the bile duct include serum bilirubin, AST, ALP, common bile duct diameter and age as independent predictors of choledocholithiasis. TUS is a sensitive test in detecting bile duct dilatation but the sensitivity is reduced in its ability to detect choledocholithiasis. A NIH consensus statement found that ERC, MRC and EUS were comparable in their sensitivities, specificities and accuracy rates for detection of choledocholithiasis. ERC and stone removal using a balloon or basket is often performed following EST. EBD may be performed if patients have uncorrected coagulopathies but the risk of pancreatitis is higher than for EST (although the risk of bleeding complications is lower for EBD). ML is often required in difficult to remove CBDS and using this device, CBDS can be removed in 90–95% of cases. Other forms of lithotripsy including laser lithotripsy and EHL are confined to specialised centres and the evidence for their use is based on small studies. ESWL may clear stones from the bile duct in up to 93% of patients but frequently ERC and stone fragment removal is required post ESWL. The role of medical therapy in difficult to remove CBDS (or in CBDS in patients with severe co-morbid illness preventing ERC + stone removal) is still currently uncertain due to a lack of large randomised control trials. 相似文献
38.
香茶菜属植物的化学成分与药理作用研究进展 总被引:2,自引:0,他引:2
我们主要综述了国内近年来有关香茶菜属植物在化学成分、药理作用、临床应用方面的研究进 展,并且讨论了这一领域的研究方向。 相似文献
39.
利用热解-色质联用分析系统,对文题进行了研究,发现其热解过程是一个复杂的多元反应过程。在500~800℃,钛酸丁酯(Ⅰ)热解尾气产物主要是烯烃、醇、醚和醛类化合物。经热解机理分析,发现Ⅰ的重排断裂反应是整个热解过程的主反应,其反应动力学常数为3.87×10~5,活化能为69.3 kJ/ 相似文献
40.
自拟人参二苓解毒汤联合盐酸恩丹西酮注射液治疗顺铂引起恶心呕吐临床观察 总被引:1,自引:0,他引:1
傅大治 《浙江中医药大学学报》2006,30(6):653-654
[目的]探讨顺铂引起恶心呕吐的有效治疗途径。[方法]对肺癌患者64例,随机分2组。自拟人参二苓解毒汤联合盐酸恩丹西酮注射液(以下简称商品名欧贝)(B组)和单独使用欧贝(A组)对顺铂为主的静脉化疗后镇吐疗效。[结果]B组(78·13%,93·75%)较A组(59·38%,75·00%)在近期镇吐治疗(指化疗后24-48h出现恶心呕吐)有明显差异(P<0·05),并在副作用方面,如便秘,乏力症状和血三系下降有明显差异(P<0·05)。[结论]辅以自拟人参二苓解毒汤确有增效解毒功能。 相似文献