岩黄连总碱药效物质基础及药理作用机制研究进展

岩黄连作为一种传统的民间中药,具有清热、解毒、止痛、止血之功效.目前针对岩黄连药理作用及其作用机制的研究主要涉及保肝、镇痛、抗肿瘤、抗菌等方面.岩黄连发挥药理作用的化学成分主要是生物碱类成分,统称为岩黄连总碱(Corydalis saxicola Bunting total alkaloids,CSBTA),而关于岩黄...     

下肢静脉曲张伴溃疡患者的病因分析和疗效观察

目的 探讨下肢静脉曲张伴溃疡（C6级）患者的常见病因和治疗效果,为临床诊治提供参考。方法 收集2020年7月至2021年12月深圳市第二人民医院收治的84例下肢静脉曲张伴溃疡患者的临床资料（共86条患肢）,汇总患者的下肢静脉彩色多普勒超声和顺行造影检查数据,观察患肢的髂静脉压迫情况、深静脉瓣膜反流情况和穿通支静脉反流情况。对患者给予综合治疗,比较治疗前后患者的静脉临床严重程度评分（VCSS）,观察治疗效果。结果 下肢静脉曲张伴溃疡患者中,髂静脉压迫患肢62条（72.1%）;深静脉瓣膜反流患肢47条（54.7%）;穿通支静脉反流患肢64条（74.4%）。溃疡患者在术后3个月的随访期内,经过规律换药,溃疡均得到了愈合,随访期内溃疡未再发。所有患者的术后VCSS为（5.83±1.19）分,低于术前的（11.86±1.89）分,差异有统计学意义（P<0.05）。结论 下肢静脉曲张伴溃疡患者中存在较高比例的髂静脉压迫、深静脉瓣膜反流、穿通支静脉反流,经过综合治疗后疗效显著。     

腔内微波和射频消融闭合大隐静脉主干的疗效及安全性对比分析

目的 探讨血管腔内微波消融（EMA）与射频消融（RFA）闭合大隐静脉主干的疗效和安全性差异。方法 收集2019年1—6月浙江省人民医院收治的316例大隐静脉功能不全患者的临床资料,并按照性别、年龄、病程、体重指数、身高、基础临床表现-病因-解剖-病理生理（CEAP）分级、大隐静脉主干直径的不同将患者筛选并分层配对为EMA组（n=157）和RFA组（n=159）。采用视觉模拟评分法（VAS）评价两组患者术后14 d的大隐静脉主干闭合段疼痛情况和皮肤瘀伤情况;术后第14天、6个月,所有患者均通过超声复查治疗段大隐静脉主干闭合情况。比较两组患者的术后并发症发生情况。结果 RFA组患者的术后VAS最高评分出现在术后第1天,EMA组患者的术后VAS最高评分出现在术后第3天。术后第1～10天,两组患者的VAS评分存在差异;与EMA组患者相比,RFA组患者的术后VAS评分更低。两组患者的皮肤瘀伤最高评分均出现在术后第4天;与EMA组患者相比,RFA组患者的皮肤瘀伤评分较低;术后第5～9天,两组患者的皮肤瘀伤评分差异较大。两组患者术后第14天、6个月的治疗段大隐静脉主干闭合率、术后并发症发生情况比较,...     

腹腔镜治疗肾盂输尿管狭窄临床疗效观察

目的观察腹腔镜治疗肾盂输尿管狭窄的临床疗效以及并发症发生率,为临床防治提供一定的理论基础。方法对100例肾盂输尿管狭窄的患者进行回顾性分析,其中腹腔镜治疗(治疗组)及常规开腹手术(对照组),各50例,比较2组治疗疗效以及并发症的发生率。结果与对照组比较,治疗组收缩压(SBP)、舒张压(DBP)、平均动脉压、心率(HR)明显升高(P<0.05),动脉血氧饱和度(SpO2)明显下降(P<0.05),但均在正常范围之内;电解质紊乱、感染、肝、肾功能不全和心律失常的发生率、手术时间、术中出血量和住院天数均明显减少(P<0.05)。结论腹腔镜辅助肾盂输尿管狭窄手术具有切口小,损伤少,术后恢复快的优势,但腹腔镜手术对呼吸循环影响较大,术中应规范操作,术后应加强护理。     

Fully Bio-Based Adhesive from Tannin and Sucrose for Plywood Manufacturing with High Performances

Fully bio-based adhesives are beneficial to reduce the dependence of the wood adhesive industry on synthetic resins based on petrochemical resources and enhance the market competitiveness of adhesives. A fully bio-based wood adhesive composed of tannin and sucrose was developed and successfully used in the preparation of plywood. Effects of the preparation technology on the bonding strength and water resistance of plywood were investigated, and the properties of the adhesive were analyzed by Fourier transform infrared spectroscopy (FT-IR), thermogravimetry (TG) and X-ray diffraction (XRD) in this study. The results showed that: (1) Compared with other biomass adhesives, tannin–sucrose adhesive had the characteristics of high-solid content and low viscosity, which had the potential to prepare particleboard and fiberboard. (2) A proper mass ratio of tannin to sucrose was key to obtaining a tannin–sucrose adhesive with better properties. (3) The optimum preparation process of tannin–sucrose adhesive for plywood was as follows: hot-pressing temperature of 210 °C, hot-pressing time of 1.2 min/mm, m(tannin):m(sucrose) of 60:40 and adhesive loading of 160 g/m². Under these conditions, the water-resistant bonding strength of the plywood was 0.89 MPa, which met the strength requirements of the Type II standard of plywood in GB/T 17657-2013. (4) The hot-pressing temperature played a decisive role in the tannin–sucrose adhesive, and the good performance of the plywood was maintained when the temperature was 210 °C or above. Thus, the prepared tannin–sucrose adhesive had high-bonding strength, good water resistance and thermal stability.     

The CSI effect in Forensic Odontology. A systematic review

The popularity of forensic science in recent decades is substantially related to the high rate of watching television programs dealing with the investigation of criminal cases, such as "CSI: Crime Scene Investigation" (CSI: Crime Scene Investigation, 2000) and the two sequels, "CSI: NY" (CSI: NY, 2004) and "CSI: Miami" (CSI: Miami, 2002). These medical-based TV series portrayed forensic science in a favorable way, encouraging viewers to experience differently this scientific field. Although it is considered a minor social phenomenon, the reality seems to diverge. The aim of this study is to systematically review the existing literature on the impact of the “CSI effect” on crime scene management, analysis, and interpretation of evidence on forensic odontology cases. Electronic research was attempted among four (4) different electronic databases from January 2005 to October 2021. After removing articles according to inclusion-exclusion criteria, the final selection resulted in 5 articles. The results indicated that forensic-based TV series provided a sense of plausibility not dependent on factual accuracy. In addition, an increasing pressure on law enforcement personnel and investigators to collect DNA at crime scenes, regardless of whether it was relevant to the case was also observed. The popularity of these TV shows has contributed to growing public interest in forensic science programs and hence the “CSI effect” had a greater impact on individuals who systematically watched such television series.     

Loading Rate and Temperature Interaction Effects on the Mode I Fracture Response of a Ductile Polyurethane Adhesive Used in the Automotive Industry

Due to their high elongation at failure and damping capacity, polyurethanes are one of the main types of adhesives used in automotive structures. However, despite the wide range of applications of adhesives, their fracture mechanics behavior is still poorly studied in the literature, especially when both the loading rate and ambient temperature change. Accordingly, the main aim of the current work is to deal with the research gap. In the current research, mode I fracture energy of a ductile polyurethane adhesive with adaptive properties for its industrial application is determined at different test speeds and temperatures. Tests were done at quasi-static, intermediate, and high-speed levels and each at three different temperatures, including low, high, and room temperature. Mode I fracture toughness was determined using DCB tests. Increasing the loading rate from quasi-static to 6000 mm/min was found to significantly increase the maximum strength of the tested DCBs (from 1770 N to about 4180 N). The greatest sensitivity to the loading rate was observed for the DCBs tested at room temperature, where the fracture energy increased by a factor of 3.5 from quasi-static (0.2 mm/min) to a high loading rate (6000 mm/min). The stiffness analysis of the DCB samples showed that the transition from below the T_g to room temperature decreases the bond stiffness by about 60%, while a further temperature increase (from 23 °C to 60 °C) has no significant effect on this parameter. Since polyurethane-bonded joints often experience a wide range of temperatures and loading rates in service, the obtained results can be used to design these joints more securely against such loading/environmental conditions.     

An Improved Optimization Model to Predict the MOR of Glulam Prepared by UF-Oxidized Starch Adhesive: A Hybrid Artificial Neural Network-Modified Genetic Algorithm Optimization Approach

The purpose of the present article is to study the bending strength of glulam prepared by plane tree (Platanus Orientalis-L) wood layers adhered by UF resin with different formaldehyde to urea molar ratios containing the modified starch adhesive with different NaOCl concentrations. Artificial neural network (ANN) as a modern tool was used to predict this response, too. The multilayer perceptron (MLP) models were used to predict the modulus of rapture (MOR) and the statistics, including the determination coefficient (R²), root mean square error (RMSE), and mean absolute percentage error (MAPE) were used to validate the prediction. Combining the ANN and the genetic algorithm by using the multiple objective and nonlinear constraint functions, the optimum point was determined based on the experimental and estimated data, respectively. The characterization analysis, performed by FTIR and XRD, was used to describe the effect of the inputs on the output. The results indicated that the statistics obtained show excellent MOR predictions by the feed-forward neural network using Levenberg–Marquardt algorithms. The comparison of the optimal output of the actual values obtained by the genetic algorithm resulting from the multi-objective function and the optimal output of the values estimated by the nonlinear constraint function indicates a minimum difference between both functions.     

低钙腹膜透析液对尿毒症患者颈动脉粥样硬化的影响

目的探讨低钙腹膜透析（PD）液对尿毒症患者颈动脉粥样硬化的影响及机制。方法将60例行连续性非卧床腹膜透析（CAPD）且合并颈动脉粥样硬化的患者随机分为A组（标准钙PD液治疗组,30例）和B组（低钙PD液治疗组,30例）,均继续行正规CAPD治疗。观察治疗12周前后患者颈动脉内-中膜厚度（IMT）及颈动脉粥样硬化斑块发生率的变化,同时生化法检测血清钙浓度,ELISA法测定血清基质金属蛋白酶-9（MMP-9）水平。结果经过12周的分组透析后,B组患者的血清钙、MMP-9[（2．25±0．24）mmol／L、（564．72±124．69）μg／L]较A组患者[（2．40±0．37）mmol／L、（718．56±111．83）μg／L]明显下降（P〈0．05）,颈动脉IMT[（1．17±0．28）mm]亦显著低于A组[（1．25±0．19）mm]（P〈0．05）。结论低钙PD液可延缓尿毒症患者颈动脉粥样硬化的进展,其对血清MMP-9的影响可能是其机制之一。     

间歇性雄激素阻断治疗晚期前列腺癌效果观察

目的 评价间歇性雄激素阻断治疗晚期前列腺癌的可行性及优点.方法 选取晚期前列腺癌患者59例,随机分为2组.给予间歇性雄激素阻断治疗30例(A组),给予持续雄激素阻断治疗29例(B组),观察两组患者的疾病进展及治疗期间副反应的发生情况,比较两种方法的治疗效果.结果 A组患者平均随访26个月,B组患者平均随访27个月,两组患者疾病进展情况未见明显差异.A组患者副反应低于B组患者且能在治疗间歇期得到缓解.结论 间歇性雄激素阻断治疗方法可行,能够减少患者治疗的副反应,提高患者生活质量.