Evidence suggesting a genetic contribution to kidney stone in northeastern Thai population

Genetic factor may play a role in the pathogenesis of kidney stone that is found in the northeastern (NE) Thai population. Herein, we report initial evidence suggesting genetic contribution to the disease in this population. We examined 1,034 subjects including 135 patients with kidney stone, 551 family members, and 348 villagers by radiography of kidney–ureter–bladder (KUB) and other methods, and also analyzed stones removed by surgical operations. One hundred and sixteen of 551 family members (21.05%) and 23 of the 348 villagers (6.61%) were affected with kidney stone. The relative risk (λ_R) of the disease among family members was 3.18. Calcium stones (whewellite, dahllite, and weddellite) were observed in about 88% of stones analyzed. Our data indicate familial aggregation of kidney stone in this population supporting that genetic factor should play some role in its pathogenesis. Genetic and genomic studies will be conducted to identify the genes associated with the disease.     

Efficacy of linagliptin on cardiovascular risk and cardiometabolic parameters in Thai patients with type 2 diabetes mellitus: A real-world observational study

Background and aimsThere is no published data on linagliptin, a dipeptidyl peptidase-4 inhibitor, on its cardiovascular risk reduction in Thai population. This study, therefore, aimed to investigate the effect of linagliptin on cardiovascular risk reduction in Thai patients with diabetes mellitus.MethodsPatient profiles of all patients treated with linagliptin in a hospital in Thailand were reviewed. Patients who had used linagliptin for at least 12 months were recruited for analysis. Their cardiovascular risk scores were calculated using the Atherosclerotic Cardiovascular Disease Risk Estimator Plus tool and were compared between pre-treatment and 12-month post-treatment of linagliptin.ResultsThere were a total of 73 patients recruited for analysis. At 12 months of treatment, the results indicated no significant reduction in the cardiovascular risk score of all patients compared to pre-treatment (25.67% vs. 23.37%, p-value 0.442). The atherosclerotic cardiovascular disease risk reduction with linagliptin was significantly higher in patients with high baseline atherosclerotic cardiovascular disease risk and in the elderly population. A significant reduction in patients with ≥20% baseline cardiovascular risk score (6.36% decrease, p-value 0.017) was observed. Significant decreases in fasting blood sugar, haemoglobin A1c, and triglyceride were observed, but not in total and LDL-cholesterol levels. Additionally, HDL-cholesterol was significantly increased.ConclusionsThe mean cardiovascular risk score of all patients was not significantly changed with 12-month linagliptin treatment. However, linagliptin could significantly reduce the 10-year cardiovascular risk score in patients with ≥20% baseline risk. Also, patients with advanced age gained more benefit from linagliptin treatment. A limitation of this study was the drugs which might affect cardiovascular risk were not collected at 12-month post-treatment.     

How do Thai children and adolescents describe asthma symptoms?

Prevalence of childhood asthma appears to be increasing worldwide. In Thailand, the prevalence of childhood asthma increased from 4.2% to 13% within the past decade. The last epidemiologic survey in Thailand utilized the International Study of Asthma and Allergies in Childhood (ISAAC) phase I questionnaire translated into Thai language. Language in the questionnaire can affect the reliability and validity of results of the survey. The purpose of this study is to determine common Thai wordings actually used by Thai children and adolescents to describe wheeze, chest tightness, shortness of breath and dyspnea. Sixty asthmatic Thai children, aged 9.2–18 years with asthmatic attacks less than 1 yr prior to the study, and 178 age‐matched controls were recruited into the study. Asthmatic children spontaneously expressed their terms describing their asthma symptoms (in Thai) and then answered a preoutlined questionnaire regarding asthma terminology during an interview session after viewing the severe attack scene of the International ISAAC video questionnaire. Controls responded only to the preoutlined questionnaire after viewing the video scene. Of the 60 asthmatic children (38 males and 22 females, mean age 11.9 yr), 75% had their last asthmatic attacks within 2 months prior to the study. Wheeze was referred to as ‘’ and ‘/wi:d/’ in 50% and 33% of patients, respectively, and ‘’ in 93.8% among controls. Using only the word ‘/wi:d/’ in our previous ISAAC‐I survey, as it sounded like the English word ‘wheeze’, it appears that up to 67% of the cases could have been missed. Dyspnea was referred to as rapid breathing and feeling tired in 78.2% of cases and as rapid and difficult breathing in 76.3% of controls. Chest tightness was referred to as chest discomfort in 65.7%. Shortness of breath was referred to as not being able to catch a breath, too short a breath, not enough breath and feeling suffocated in 88.8%. Local terms for asthma symptoms should be established and validated into each language to obtain reliable epidemiologic data.     

Signal detection for Thai traditional medicine: Examination of national pharmacovigilance data using reporting odds ratio and reported population attributable risk

Herbal containing medicine consumption has increased while the awareness of adverse drug reaction (ADR) was less than conventional medicine. Early detection of unexpected numbers of ADRs from herbal medicines’ reports which are abnormal from the whole database needs quantification. Disproportionality analysis has been performed for signal detection by using reporting odds ratio (ROR) as measurement. The impact of having medicine as exposures in each ADR should be measured by using reported population attributable risks (RPAR). This study aimed to quantify the contribution of Thai traditional medicine (TTM) to ADR reports and to assess the association between TTMs and serious adverse drug reactions. Data were retrieved from the adverse drug reaction surveillance database, Thai-Food and Drug Administration from 2002 to 2013. Crude and adjusted RORs for each drug–ADR pair and RPARs were computed. TTM contributed only 0.001% of all serious ADRs reported. Out of 4208 TTM-ADR pairs were examined, three had the statistically significant RORs, namely Andrographis paniculata and anaphylactic shock (ROR 2.32, 95% CI 1.03, 5.21); green traditional medicine and Stevens-Johnson syndrome (ROR 13.04, 95% CI 5.4–31.51) and Derris scandens Benth and angioedema (ROR 2.71, 95% CI 1.05–6.95). Their RPARs ranged from 0.05% to 0.16%. We conclude that TTMs need more intensive surveillance.     

Reliability of the Functional Independence Measure for children in normal Thai children

BACKGROUND: The Functional Independence Measure for children (WeeFIM) is a new instrument for evaluating functionality in disabled children aged 9-100 months. It was developed to determine a child's functional capacity and performance. With no baseline information about Thai children, it is difficult to assess whether a patient is initially high or low with respect to function. METHODS: The aim of this study, therefore, was to evaluate the interrater, intrarater reliability and appropriateness of the use of the WeeFIM and to establish a normative data profile suitable for Thai children. The WeeFIM is an instrument used to assess independence in self-care, sphincter control, transfer, locomotion, communication, and social cognition. RESULTS: Direct interviews were conducted in the communities for 569 normal Thai children (289 girls and 280 boys) aged 6-100 months. The interrater and intrarater reliability scores were examined. The WeeFIM total and domain scores increased progressively with age. Intraclass correlation coefficients for the reliability for the WeeFIM domain score ranged from 0.90 to 0.99. Total WeeFIM intraclass correlation coefficients values were greater than 0.97 for all analyses. The authors classified the 18 items into six groups according to the degree of correlation with age. Most items were highly correlated with age as indicated by a Spearman's correlation coefficient greater than 0.8. The interrater and intrarater reliability of the WeeFIM subscores was high. CONCLUSION: The current study demonstrated that WeeFIM could be employed as a useful and reliable instrument for assessing functional independence for Thai children. Therefore, usage of WeeFIM with different age criteria for achieving independence should be adopted. Normative functional independence measures for a large group of Thai children will enhance the knowledge base about their development measurement and provide a database for future investigations on clinical population in Thailand.     

Childhood Asthma in Thailand

Asthma is common in Thai children with a prevalence of about 4%. A prospective study of 2,000 Thai asthmatic children showed boys to be more frequently affected than girls, and fifty percent of patients experienced their first attack within the first 2 years of life. Attacks usually occurred in winter and the rainy season. 63.15% of patients had asthma associated with other allergic diseases and 79.25% had a family history of allergic diseases. Positive skin tests to important antigens were noted in 93.7% of cases, and house dust was the most common. Pharmacokinetic studies of theophylline were made in Thai asthmatic children after oral administration revealed that the elimination half-life of theophylline was longer than that observed in subjects in Western countries. Long-term follow up of 247 Thai asthmatic children revealed that in 37.2% of patients, symptoms ceased at the age of 15 years. The factors which indicated a favorable prognosis included male sex, mild or moderate illness, negative skin tests or positive skin tests to only a few allergens.